Hladek, Luca Bankov, Katrin von der Grün, Jens Filmann, Natalie Demes, Melanie Vallo, Stefan Wild, Peter J Winkelmann, Ria
Published in
Virchows Archiv : an international journal of pathology
Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapt...
Lerch, Julia M Pai, Rish K Brown, Ian Gill, Anthony J Jain, Dhanpat Kővári, Bence Kushima, Ryoji Sheahan, Kieran Slavik, Tomas Srivastava, Amitabh
...
Published in
Virchows Archiv : an international journal of pathology
The extent of gastric intestinal metaplasia (GIM) can be used to determine the risk of gastric cancer. Eleven international gastrointestinal expert pathologists estimated the extent of GIM on haematoxylin and eosin (H&E)- and Alcian blue-Periodic acid Schiff (AB-PAS)-stained slides of 46 antrum biopsies in 5% increments. Interobserver agreement was...
Seyrek, Neslisah Hollemans, Eva Andrinopoulou, Eleni-Rosalina Osanto, Susanne Pelger, Rob C M van der Poel, Henk G Bekers, Elise Remmers, Sebastiaan Schoots, Ivo G van Leenders, Geert J L H
...
Published in
Virchows Archiv : an international journal of pathology
Percentage Gleason pattern 4, invasive cribriform and/or intraductal carcinoma (IC/IDC) and minor pattern 5 are recognized as independent parameters for prostate cancer outcome, but are not incorporated in current grade groups (GGs). Two proof-of-principle studies have proposed alternative grading schemes based on percentage Gleason pattern 4/5 (in...
Yamashita, Kyoko Funauchi, Yuki Hayakawa, Keiko Ae, Keisuke Matsumoto, Seiichi Ikuta, Kunihiro Nishida, Yoshihiro Ueno, Teruko Shimoyama, Yoshie Hiruta, Nobuyuki
...
Published in
Virchows Archiv : an international journal of pathology
Epithelioid malignant peripheral nerve sheath tumor (MPNST) is a rare subtype of MPNST composed of epithelioid cells with abundant cytoplasm. Currently, strong and diffuse immunostaining for S100 protein and SOX10 is generally regarded as a characteristic feature of epithelioid MPNST. However, malignant tumors with epithelioid morphology that arise...
Qiu, Yan Jing, Wenyi Zhou, Ying Chen, Huijiao Chen, Min Zhang, Hongying
Published in
Virchows Archiv : an international journal of pathology
Deletion of the neurofibromatosis 1 (NF1) gene is common, but NF1 rearrangement or fusion has rarely been reported in peripheral nerve sheath tumors. Here, we present a case of malignant peripheral nerve sheath tumor (MPNST) in a 36-year-old Chinese female. Histologically, the lesion was composed of spindle cells with moderate atypia, immature bone...
Pichler Sekulic, Simona Sekulic, Miroslav
Published in
Virchows Archiv : an international journal of pathology
Lymphangiomas are comprised of aggregates of lymphatic vessels, considered to represent either aberrant embryogenic remnants or developing secondary to obstruction. Lymphangiomas primary to the heart and pericardial are exceedingly rare, and to date sparingly reported in individual case reports. In this study, the histopathologic, clinical, and rad...
Santi, Raffaella Ballestriero, Roberta Canzonieri, Vincenzo Gulcznsky, Jacek de Gouveia, Rosa Henriques Ariza, Aurelio Carvalho, Lina Nesi, Gabriella
Published in
Virchows Archiv : an international journal of pathology
While keeping their original purpose of training medical students, pathology museums hold great biological value, offering unique specimens for scientific research through modern radiological, pathological and biomolecular techniques. Moreover, the artefacts, models and drawings displayed in these museums are a precious cultural and artistic herita...
Sakihama, Kukiko Koga, Yutaka Yamamoto, Takeo Shimada, Yuki Yamada, Yutaka Kawata, Jun Shindo, Koji Nakamura, Masafumi Oda, Yoshinao
Published in
Virchows Archiv : an international journal of pathology
Mucinous cystic neoplasm (MCN) of the pancreas rarely progresses to invasive carcinoma, but few studies have analyzed genomic alterations involved in its malignant transformation. The relationships of ring finger protein 43 (RNF43) mutations with cytological atypia, RNF43 protein expression, and Wnt signaling proteins in MCN remain unclear. This st...
Liu, Jiahan Mao, Rongjun Lao, I Weng Yu, Lin Bai, Qianming Zhou, Xiaoyan Wang, Jian
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Virchows Archiv : an international journal of pathology
We report 10 additional cases of GLI1-altered mesenchymal tumor to further delineate its clinicopathological and molecular spectrum. There were seven males and three females with a median age of 31 years (range 1.3 ~ 75 years). Five tumors arose in the oral cavity, one each in the stomach, uterine cervix, elbow, groin, and thigh. Histologically, al...
Agaimy, Abbas Meidenbauer, Norbert Sukov, William R Stoehr, Robert Vieth, Michael Roemer, Frank Grützmann, Robert Folpe, Andrew L
Published in
Virchows Archiv : an international journal of pathology
Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts and hemosiderotic fibrolipomatous tumor (HFLT) are two rare low-grade locally recurring neoplasms with predilection for the foot/ankle. Recent studies support a close link between the two entities, and origin of PHAT from HFLT and occurrence of hybrid HFLT/PHAT have been documented. Bot...
