In reply to: letter to the editor entitled: primary pure lymphoepithelioma-like carcinoma of the ureter.
...Published in Virchows Archiv : an international journal of pathology
The clinicopathologic spectrum of mature aggressive B cell lymphomas.
...Published in Virchows Archiv : an international journal of pathology
Our understanding of mature aggressive B cell lymphomas has evolved significantly in the last years as reflected in the 2016 update of the WHO lymphoma classification. A main topic of the 2016 European Association for Haematopathology/Society of Hematopathology lymphoma workshop in Basel therefore was the clinicopathological spectrum of mature aggr...
Is Rosai-Dorfman disease a reactve process? Detection of a MAP2K1 L115V mutation in a case of Rosai-Dorfman disease.
Published in Virchows Archiv : an international journal of pathology
HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human ...
...Published in Virchows Archiv : an international journal of pathology
The current study aims to investigate the biological roles and clinical significance of HCRP1 in human gastric cancer. The expression pattern of HCRP1 in gastric cancer tissue and adjacent non-cancerous tissue was detected by immunohistochemistry. HCRP1 downregulation was found in 57 of 137 human gastric cancer samples and correlated with advanced ...
Quality in pathology.
Published in Virchows Archiv : an international journal of pathology
Transcriptome comparison identifies potential biomarkers of spine and skull base chordomas.
Published in Virchows Archiv : an international journal of pathology
Chordomas are rare, slowly growing, locally aggressive bone neoplasms that arise from embryonic remnants of the notochord, showing dual epithelial-mesenchymal differentiation. The high plasticity probably is the main reason for the high variety in phenotypes of chordoma, from its high heterogeneity on a cellular level to its subtype variations depe...
Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse ou...
Published in Virchows Archiv : an international journal of pathology
SOX2 is a regulatory factor of embryonic stem cells that has been implicated in carcinogenesis and cancer progression. We aimed to investigate the potential role of SOX2 in the stepwise progression from pleomorphic adenoma (PA) to invasive carcinoma ex pleomorphic adenoma (CXPA), evaluating its prognostic significance as well. Thirty PAs without ma...
Multisite tumor sampling enhances the detection of intratumor heterogeneity at all different temporal stages of tumor ev...
Published in Virchows Archiv : an international journal of pathology
Intratumor heterogeneity (ITH) is an inherent process of tumor development that has received much attention in previous years, as it has become a major obstacle for the success of targeted therapies. ITH is also temporally unpredictable across tumor evolution, which makes its precise characterization even more problematic since detection success de...
FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated co...
Published in Virchows Archiv : an international journal of pathology
Invasive bladder cancer is diverse, and includes several named histomorphologies that differ from conventional urothelial carcinoma, termed "histologic variants." By transcriptional analysis, bladder cancers can be divided into luminal and basal subtypes. In this paper, we study associations between markers of transcriptional subtypes and variant h...
Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype.
Published in Virchows Archiv : an international journal of pathology
Several different histological subtypes of penile carcinoma had been described in the last decades, many with different biological behavior and prognosis. The association of two histological subtypes (mixed tumors) can be observed in one third of the cases. The most common association is of warty and basaloid tumors, two HPV-related carcinomas. Her...
