Lin, Jui-Hsiang Huang, Yi-Ting Yu, Jih-Chang Chan, Kin-Wei Arnold Huang, Yen-Tsung
Published in
Vaccine
Immune correlate analyses for vaccine trials have been applied to investigate associations of vaccine efficacy and surrogate markers such as vaccine-induced antibodies. However, the role of antibody as a surrogate marker in predicting the outcome can vary by time, and surrogate-outcome confounding may have resulted in bias even in randomized trials...
Grignolio Corsini, Andrea Zagarella, Roberta Martina Adamo, Massimiliano Caporale, Cinzia
Published in
Vaccine
The aim of the study is to understand the evolution of COVID-19 vaccine acceptance over the key 7-month vaccine campaign in Italy, a period in which the country moved from candidate vaccines to products administered to the public. The research focus points to evaluate COVID-19 vaccine attitudes in adults and their children, propension towards compu...
Estephan, Lila Liu, Luke Tzu-Chi Lien, Chia En Smith, Emily R Gurwith, Marc Chen, Robert T
Published in
Vaccine
The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) Working Group has prepared standardized templates to describe the key considerations for the benefit-risk assessment of several vaccine platform technologies, including protein subunit vaccines. This article uses the BRAVATO template to review the features of the...
Thwaites, C Louise Thanh, Tran Tan Ny, Nguyen Thi Han Nguyet, Lam Anh Nhat, Nguyen Thi Duy Thuy, Cao Thu Thanh, Nguyen Thi Le Dung, Nguyen Thanh Campbell, James Thai, Pham Quang
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Published in
Vaccine
Ongoing tetanus cases and sporadic outbreaks of vaccine-preventable diseases associated with routine vaccination programmes remain problems in many low and middle-income countries, including Vietnam. With no human-to-human transmission or natural immunity, tetanus antibody levels indicate both individual risk of tetanus and gaps in vaccination prog...
Chang, Ai-Mei Chen, Chen-Chih Lee, Jai-Wei Hou, Ding-Liang Huang, Hsiao-Hui Ke, Guan-Ming
Published in
Vaccine
Immunocastration is an effective alternative to surgical castration for controlling the population of animals. As gonadotropin-releasing hormone (GnRH) regulates the reproductive endocrine system in mammals, it is a target antigen for vaccine formulation. Through this study, we evaluated the effectiveness of a recombinant subunit GnRH-1 vaccine for...
Guerin, Rebecca J Naeim, Arash Baxter-King, Ryan Okun, Andrea H Holliday, Derek Vavreck, Lynn
Published in
Vaccine
Bakhshizadeh Gashti, Anahita Chahal, Parminder S Gaillet, Bruno Garnier, Alain
Published in
Vaccine
In this work, laboratory- and large-scale methods were tested for purification of a human immunodeficiency virus (HIV) vaccine candidate, based on recombinant vesicular stomatitis virus (rVSV). First step of the purification, the clarification of the rVSVs produced in serum-free cell culture medium, was tested by centrifugation and filtration using...
Feitsma, Eline A Janssen, Yester F Boersma, Hendrikus H van Sleen, Yannick van Baarle, Debbie Alleva, David G Lancaster, Thomas M Sathiyaseelan, Thillainaygam Murikipudi, Sylaja Delpero, Andrea R
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Published in
Vaccine
Previous interim data from a phase I study of AKS-452, a subunit vaccine comprising an Fc fusion of the respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor binding domain (SP/RBD) emulsified in the water-in-oil adjuvant, Montanide⢠ISA 720, suggested a good safety and immunogenicity profile in healthy adults. This phase I study w...
Uttekar, Shraddha MacDonald, Noni Orenstein, Walter A Danchin, Margie Blaser, Vince Thomson, Angus Menning, Lisa Shimp, Lora Rath, Barbara Limaye, Rupali
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Published in
Vaccine
The quality of interactions between health workers (HWs) and caregivers is key in vaccine acceptance. To optimize this, HWs need knowledge about best vaccine communication practices in person and on social media. Most pre-service curricula do not include such approaches. COVID-19 necessitated the International Pediatric Association (IPA) to shift f...
Hsiao, Amber Struckmann, Verena Stephani, Victor Mmbando, Devis Changalucha, John Baisley, Kathy Levin, Ann Morgan, Winthrop Hutubessy, Raymond Watson-Jones, Deborah
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Published in
Vaccine
As part of the Dose Reduction Immunobridging and Safety Study of Two HPV Vaccines in Tanzanian Girls (DoRIS; NCT02834637), the current study is one of the first to evaluate the financial and economic costs of the national rollout of an HPV vaccination program in school-aged girls in sub-Saharan Africa and the potential costs associated with a singl...