Apart, together: reflections on the COVID-19 pandemic
Published in Trends in Cell Biology
Apart, together: reflections on the COVID-19 pandemic
Tracking Mechanisms of Viral Dissemination In Vivo.
Published in Trends in cell biology
Dissemination and replication of viruses into hosts is a multistep process where viral particles infect, navigate, and indoctrinate various cell types. Viruses can reach tissues that are distant from their infection site by subverting subcellular mechanisms in ways that are, sometimes, disruptive. Modeling these steps, at appropriate resolution and...
Mitochondrial Functions in Infection and Immunity: (Trends in Cell Biology 30, 263-275, 2020).
Published in Trends in cell biology
Mitochondrial Functions in Infection and Immunity.
Published in Trends in cell biology
Mitochondria have a central role in regulating a range of cellular activities and host responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and functions to influence their intracellular survival or evade host immunity. On the other side, major host responses elicited against infections are directly dependent on mitoc...
Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties
Published in Trends in Cell Biology
Lysosome: regulator of lipid degradation pathways.
Published in Trends in cell biology
Autophagy is a catabolic pathway that has a fundamental role in the adaptation to fasting and primarily relies on the activity of the endolysosomal system, to which the autophagosome targets substrates for degradation. Recent studies have revealed that the lysosomal-autophagic pathway plays an important part in the early steps of lipid degradation....
Mitochondria: from cell death executioners to regulators of cell differentiation.
Published in Trends in cell biology
Most, if not all mitochondrial functions, including adenosine-5'-triphosphate (ATP) production and regulation of apoptosis and Ca(2+) homeostasis, are inextricably linked to mitochondrial morphology and dynamics, a process controlled by a family of GTP-dependent dynamin related 'mitochondria-shaping' proteins. Mitochondrial fusion and fission direc...
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
Published in Trends in Cell Biology
Many tumors undergo a dramatic metabolic shift known as the Warburg effect in which glucose utilization is favoured and oxidative phosphorylation is down-regulated, even when oxygen availability is plentiful. However, the mechanistic basis for this switch has remained unclear. Recently several independent groups identified TRAP1, a mitochondrial mo...
Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair
Published in Trends in Cell Biology
The cellular response to DNA double-stranded breaks (DSBs) involves a conserved mechanism of recruitment and activation of numerous proteins involved in this pathway. The events that trigger this response in mammalian cells involve several post-translational modifications, but the role of non-proteasomal ubiquitin signaling is particularly central ...
Evolutionary mechanisms for establishing eukaryotic cellular complexity
Published in Trends in Cell Biology
Through a comparative approach, evolutionary cell biology makes use of genomics, bioinformatics, and cell biology of non-model eukaryotes to provide new avenues for understanding basic cellular processes. This approach has led to proposed mechanisms underpinning the evolution of eukaryotic cellular organization including endosymbiotic and autogenou...
