Omics and Machine Learning in Transfusion Medicine
Published in Transfusion Medicine and Hemotherapy
Omics and Machine Learning in Transfusion Medicine
Omics Technologies in Veterinary Medicine: Literature Review and Perspectives in Transfusion Medicine
Published in Transfusion Medicine and Hemotherapy
Background: Omics technologies represent a new analytical approach that allows a full cellular readout through the simultaneous analysis of thousands of molecules. The application of such technologies represents a flourishing field of research in human medicine, especially in transfusion medicine, while their application in veterinary medicine stil...
Big Data in Transfusion Medicine and Artificial Intelligence Analysis for Red Blood Cell Quality Control
Published in Transfusion Medicine and Hemotherapy
Background: “Artificial intelligence” and “big data” increasingly take the step from just being interesting concepts to being relevant or even part of our lives. This general statement holds also true for transfusion medicine. Besides all advancements in transfusion medicine, there is not yet an established red blood cell quality measure, which is ...
Too Early to Abandon Convalescent Plasma for Supportive Treatment of COVID-19
Published in Transfusion Medicine and Hemotherapy
The authors of a systematic review and meta-analysis conclude that the benefit of convalescent plasma (CP) in the treatment of COVID-19 is limited. Among other systematic reviews, only one found an indication of benefit of CP. However, a meta-analysis needs a focused and meaningful clinical question and should include studies which are designed to ...
Circulating Iron in Patients with Sickle Cell Disease Mediates the Release of Neutrophil Extracellular Traps
Published in Transfusion Medicine and Hemotherapy
Introduction: Neutrophils promote chronic inflammation and release neutrophil extracellular traps (NETs) that can drive inflammatory responses. Inflammation influences progression of sickle cell disease (SCD), and a role for NETs has been suggested in the onset of vaso-occlusive crisis (VOC). We aimed to identify factors in the circulation of these...
Principles of Therapeutic Apheresis in Neurological Disease
Published in Transfusion Medicine and Hemotherapy
Background: Therapeutic plasma exchange (TPE) is a well-known apheresis technology since many years and is available worldwide. Myasthenia gravis is one of the first neurological diseases successfully treated with TPE. TPE is also frequently applied in acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome). Both neurologi...
Predicting Individual Patient Platelet Demand in a Large Tertiary Care Hospital Using Machine Learning
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Published in Transfusion Medicine and Hemotherapy
Introduction: An increasing shortage of donor blood is expected, considering the demographic change in Germany. Due to the short shelf life and varying daily fluctuations in consumption, the storage of platelet concentrates (PCs) becomes challenging. This emphasizes the need for reliable prediction of needed PCs for the blood bank inventories. Ther...
Red Blood Cell Omics and Machine Learning in Transfusion Medicine: Singularity Is Near
Published in Transfusion Medicine and Hemotherapy
Background: Blood transfusion is a life-saving intervention for millions of recipients worldwide. Over the last 15 years, the advent of high-throughput, affordable omics technologies – including genomics, proteomics, lipidomics, and metabolomics – has allowed transfusion medicine to revisit the biology of blood donors, stored blood products, and tr...
How to Ensure Blood Supply and Blood Safety in the Future
Published in Transfusion Medicine and Hemotherapy
Diagnosis of Bone Marrow Necrosis following Severe Vaso-Occlusive Crisis in Patient with Compound Heterozygous Sickle Ce...
Published in Transfusion Medicine and Hemotherapy
Introduction: Bone marrow necrosis is a rare entity that can develop in context of a sickle cell disease vaso-occlusive crisis. Its physiopathology is related to an endothelial dysfunction taking place in bone marrow microvasculature. Case Presentation: A 30-year-old patient with history of compound heterozygous sickle cell disease was admitted fol...
