President's Address: The Climatological: A Historical Perspective.
Published in Transactions of the American Clinical and Climatological Association
THE POWER OF POOP: FECAL MICROBIOTA TRANSPLANTATION FOR CLOSTRIDIUM DIFFICILE INFECTION.
Published in Transactions of the American Clinical and Climatological Association
The human gut is colonized with 200 to 1,000 bacterial species. Administration of antibiotics reduces the diversity of the intestinal microbiota, reduces colonization resistance, and can lead to infection with Clostridium difficile. These infections have become more prevalent and increasingly patients are experiencing multiple recurrences that are ...
IMPROVING LONG-TERM OUTCOMES IN KIDNEY TRANSPLANTATION: TOWARDS A NEW PARADIGM OF POST-TRANSPLANT CARE IN THE UNITED STA...
Published in Transactions of the American Clinical and Climatological Association
Since the 1950s, care for kidney transplant recipients in the United States has evolved around a model in which clinical management, quality metrics, and financial underpinnings are focused around the surgical procedure itself reflecting the concept that perioperative and short-term interventions are primary determinants of success. In the current ...
THE GORDON WILSON LECTURE EVOLUTION OF CLINICAL CANCER GENETICS.
Published in Transactions of the American Clinical and Climatological Association
PREVENTING THE CHROMOSOMAL TRANSLOCATIONS THAT CAUSE CANCER.
Published in Transactions of the American Clinical and Climatological Association
Approximately half of all cancers harbor chromosomal translocations that can either contribute to their origin or govern their subsequent behavior. Chromosomal translocations by definition can only occur when there are two DNA double-strand breaks (DSBs) on distinct chromosomes that are repaired heterologously. Thus, chromosomal translocations are ...
TOWARDS THE DEVELOPMENT OF NOVEL THERAPEUTICS FOR PERIPHERAL ARTERY DISEASE.
Published in Transactions of the American Clinical and Climatological Association
Atherosclerosis is the leading cause of morbidity and mortality in the Western world. Peripheral artery disease (PAD) has been less studied then coronary artery disease but is nearly as common. PAD impairs blood flow to the leg(s) and causes functional impairment, leg pain, and amputation. The last drug approved for PAD was in 1999. Blood flow to l...
EDUCATE TO TRANSFORM: THE ART OF DEVELOPING CURIOUS MINDS.
Published in Transactions of the American Clinical and Climatological Association
With rapid changes in health care and academic medicine, deans and medical educators need to carefully optimize medical education in order to best prepare our students for the future. Fundamentally, it is critical that future medical practitioners develop curious minds that look beyond the obvious to ask questions not yet asked and glean reality. T...
CLINICAL EVALUATION OF AN EPIGENETIC ASSAY TO PREDICT MISSED CANCER IN PROSTATE BIOPSY SPECIMENS.
Published in Transactions of the American Clinical and Climatological Association
Approximately 1 million prostate biopsies are performed yearly in the United States, with only ~25% resulting in prostate cancer diagnosis. However, ~40% of men receive multiple biopsies for fear of cancer being missed. DNA hypermethylation is ideally suited for early disease detection and could be used to prevent unnecessary biopsies. Men with low...
THE SHARK RECTAL GLAND MODEL: A CHAMPION OF RECEPTOR MEDIATED CHLORIDE SECRETION THROUGH CFTR.
Published in Transactions of the American Clinical and Climatological Association
The dogfish shark salt gland was predicted by Smith and discovered by Burger at the Mount Desert Island Biological Laboratory in Salisbury Cove, Maine. It is an epithelial organ in the intestine composed of tubules that serve a single function: the secretion of hypertonic NaCl. Many G protein receptors are present on the basolateral surface of thes...
THE BERT AND PEGGY DUPONT LECTURE MUSIC AND MEDICINE: GEORGE GERSHWIN.
Published in Transactions of the American Clinical and Climatological Association
