Chorionic villus sampling (CVS) allows for earlier results for aneuploidy or genomic abnormalities compared to amniocentesis. Nevertheless, the inability to provide complete results has been described as being more frequent with CVS. This study was conducted in order to identify risk factors for such failures. A retrospective single-center study wa...
In utero neurologic injury in myelomeningocele (MMC) occurs via a two-hit process: failed neural tube closure followed by neurodegeneration in utero. Meconium in the amniotic fluid contains pancreatic digestive enzymes and is neurotoxic in rat models of MMC. The objectives of this study were to demonstrate the neurotoxicity of α-amylase and to comp...
Polymorphism of estrogen receptor α (ESR1) polymorphisms plays an important role in the adaptation of increased uterine blood flow during gestation. Published data on the association between the ESR1 polymorphisms and preeclampsia risk are controversial. A meta-analysis was performed to assess whether the polymorphisms of ESR1 are associated with p...
To compare the changes in the pelvic floor of women with twin pregnancies who practiced muscle stretching with the EPI-NO® vaginal dilator, as assessed using transperineal three-dimensional ultrasound (3DUS). This prospective cross-sectional case-control study included nulliparous women in the third trimester of their multiple pregnancies and divid...
We assessed the natural history of the different types of isolated ventricular septal defects (VSDs) diagnosed by fetal echocardiography and analyzed their postnatal outcomes. This is a retrospective cohort study of 86 fetuses with isolated VSDs, detected in 7466 sequential echocardiographic examinations. The subtype and size of the VSDs were asses...
Nonovert disseminated intravascular coagulation (DIC) is a subclinical hemostatic dysfunction that has not yet reached the decompensation stage. The detection of pregnant patients at this stage may assist in the identification of those who will develop severe obstetrical hemorrhage, as it is one of the leading causes for preventable maternal mortal...
There are three types of decidual vasculopathy at term, acute atherosis, fibrinoid medial necrosis, and mural arterial hypertrophy with two separate mechanisms. Acute atherosis and fibrinoid medial necrosis demonstrate the replacement of the muscular wall by the fibrinoid material and "foamy cells", whereas mural arterial hypertrophy depicts thicke...
Although amnioinfusion (AI) for repetitive variable deceleration has been reported to reduce the frequency of variable deceleration and cesarean section (CS) rate, CS is sometimes unavoidable even after therapeutic AI. The purpose of this study was to investigate prenatal factors related to the efficacy of therapeutic AI during labor. This retrospe...
To compare the effectiveness of expectant management (EM), cervical cerclage (CC) and vaginal progesterone (VP) in decreasing the rate of spontaneous preterm birth in twin gestations with midtrimester cervical shortening. This is a retrospective cohort study comparing pregnancy outcomes of twin gestations with midtrimester cervical shortening, defi...
Current policy and service provision recommend a woman-centered approach to maternity care and the development of personalized models for clinical assistance. Ethnicity has been recognized as a determinant in the risk calculation of selected obstetric complications. Based on these assumptions, our aims were to describe the linkage between baseline ...
