Wu, Yuting Yue, Yun Fu, Shu Li, Yeli Wu, Dongqing Lv, Junyuan Yang, Danli
Published in
The Journal of pharmacy and pharmacology
Reducing endoplasmic reticulum stress (ERS)-induced cardiomyocyte apoptosis is a key strategy for preventing hypertensive heart disease. In our previous study, Icariside II can improve left ventricular remodelling in spontaneously hypertensive rats (SHRs). This study aims to determine whether Icariside II can exert its effect by inhibiting ERS-indu...
Berrío Escobar, Jhon Fernando Márquez Fernández, Diana Margarita Giordani, Cristiano Castelli, Francesco Sarpietro, Maria Grazia
Published in
The Journal of pharmacy and pharmacology
Uridine was conjugated with fatty acids to improve the drug lipophilicity and the interaction with phospholipid bilayers. The esterification reaction using carbodiimides compounds as coupling agents and a nucleophilic catalyst allowed us to synthesize tri-acyl ester derivatives of uridine with fatty acids. Analysis of molecular interactions between...
Dias, Katia Cilene Ferreira de Almeida, Jamily Cunha Vasconcelos, Luna Costa Patrocínio, Marianna Letícia Vasconcelos... Barbosa, Talita Matias Ximenes, Naiara Coelho Leitão, Ana Paula de Azevedo Louchard, Bianca Oliveira Pimenta, Antônia Torres Ávila Pinto, Francisco das Chagas Lima
...
Published in
The Journal of pharmacy and pharmacology
To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine-induced schizophrenia model. Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET admini...
Beydogan, Alisa Bahar Coskun, Zeynep Mine Bolkent, Sema
Published in
The Journal of pharmacy and pharmacology
A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Δ9 -tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The study aims to investigate the effects of THC treatment on inflammation, lipid profiles and oxidative stress in rat liver with hyperinsulinemia. Sp...
Pesoa, Juan I Rico, María J Rozados, Viviana R Scharovsky, O Graciela Luna, Julio A Mengatto, Luciano N
Published in
The Journal of pharmacy and pharmacology
To evaluate the combination of more than one release system in the same formulation as a useful strategy to achieve paclitaxel delivery in a more sustained and controlled manner. The present study deals with the preparation of poly(lactide-co-glycolide) microparticles loaded with paclitaxel and included in a chitosan thermo-sensitive gelling soluti...
Garg, Gaurav Patil, Amol Singh, Jagjit Kaushik, Nutan Praksah, Ajay Pal, Arnab Chakrabarti, Amitava
Published in
The Journal of pharmacy and pharmacology
The aim of the study was to evaluate the effect of Convolvulus pluricaulis (CP; C. pluricaulis) methanolic extract on Triton WR-1339-induced hyperlipidaemia in rats. The study comprised of six groups namely normal control, experimental control and treatment groups (100, 200 and 400 mg/kg of C. pluricaulis, and 65 mg/kg of Fenofibrate). Hyperlipidae...
Lin, Hai Zhou, Ai-Jun Zhang, Jing-Yu Liu, Shu-Fang Gu, Jian-Xiang
Published in
The Journal of pharmacy and pharmacology
The purpose of this study was to further clarify the role and underlying mechanism of miR-324-5p in gastric cancer. The expressions of miR-324-5p and TSPAN8 as determined by qRT-PCR or Western blot were compared between the gastric cancer tissues and normal tissues. Human gastric cancer cell line SGC-7901 was cultured and transfected with miR-324-5...
Martinez, Renata M Ivan, Ana L M Vale, David L Campanini, Marcela Z Ferreira, Vitor S Steffen, Vinicius S Vicentini, Fabiana T M C Vilela, Fernanda M P Fonseca, Maria J V Baracat, Marcela M
...
Published in
The Journal of pharmacy and pharmacology
To evaluate the effects of a topical emulsion containing pyrrolidine dithiocarbamate (PDTC) (EcPDTC) in skin oxidative stress and inflammation triggered by ultraviolet B (UVB) irradiation (dose of 4.14 J/cm2 ). Hairless mouse received treatment with 0.5 g of EcPDTC or control emulsion (CTRLE) on the dorsal surface skin 12 h, 6 h and 5 min before an...
Rodeiro, Idania Hernández, Ivones Herrera, José A Riera, Mario Donato, Maria T Tolosa, Laia González, Kethia Ansoar, Yadira Gómez-Lechón, Maria J Vanden Berghe, Wim
...
Published in
The Journal of pharmacy and pharmacology
Reported antioxidant, anti-inflammatory and neuroprotective properties for one aqueous-ethanolic extract from Thalassia testudinum which grows in the Caribbean Sea compelled us to explore about extract cytotoxic effects. Cell viability was assayed on tumour (HepG2, PC12, Caco-2 and 4T1) and non-tumour (VERO, 3T3, CHO, MCDK and BHK2) cell lines. The...
Zengin, Gokhan Llorent-Martínez, Eulogio J Molina-García, Lucía Fernández-de Córdova, María Luisa Aktumsek, Abdurrahman Uysal, Sengul Rengasamy, Kannan R R Aumeeruddy, Muhammad Zakariyyah Bahadori, Mir Babak Mahomoodally, Mohamad Fawzi
...
Published in
The Journal of pharmacy and pharmacology
This study investigates into the biological effects of solvent extracts (ethyl acetate, methanol, and water) of Scutellaria orientalis L. and Scutellaria salviifolia Benth. based on its enzyme inhibitory activity and antioxidant ability together with the screening of bioactive compounds. Total and individual bioactive components were determined usi...
