Liu, Jia Zhang, Qing Li, Ruo-Lan Wei, Shu-Jun Huang, Chun-Yan Gao, Yong-Xiang Pu, Xu-Feng
Published in
The Journal of pharmacy and pharmacology
Cinnamomi ramulus (called Guizhi in Chinese) is a traditional medicine used to treat gastrointestinal dysfunction, cancer, arthritis, osteoporosis, spleen deficiency, Alzheimer's disease and obesity. This review aimed to provide a systematic summary on the geographical distribution, botany, traditional application, phytochemistry, pharmacology, pha...
Dopart, Rachel Kendall, Debra A.
Published in
The Journal of pharmacy and pharmacology
Single mutations in extracellular loop 1 or 2 of CB1 showed weak or no binding of agonist CP55940 to the receptor. Interestingly, upon addition of the allosteric modulator PSNCBAM-1, this binding was restored typically to wild-type CB1 levels. In a few cases, the allosteric modulator ORG27569 was compared with PSNCBAM-1 for CP55940 binding and it a...
Paraiso, Rafael Leal Monteiro Watanabe, Ayahisa Andreas, Cord J Turner, David Zane, Patricia Dressman, Jennifer
Published in
The Journal of pharmacy and pharmacology
The main objective of the present work was to combine in-vitro and in-silico tools to better understand the in-vivo behavior of the immediate release (IR) formulation of zolpidem in the fasted and fed states. The dissolution of zolpidem was evaluated using biorelevant media simulating the gastric and intestinal environment in the fasted and fed sta...
Hu, Xuelian Wan, Chunmei Gan, Zongjie Liu, Rongxing Chen, Yongjie Wang, Jing Gan, Linling Chen, Yuhang Li, Yingbo He, Baicheng
...
Published in
The Journal of pharmacy and pharmacology
TNBG-5602 is a newly synthesized compound with an isoquinoline structure. In the present study, we demonstrated the anticancer effect of TNBG-5602 in in-vitro and in-vivo models and investigated its possible anticancer mechanism. The antiproliferation effect of TNBG-5602 in vitro was evaluated in human liver cancer cell line QGY-7701. The acute tox...
Jürgenson, Monika Zharkovskaja, Tamara Noortoots, Aveli Morozova, Margarita Beniashvili, Allan Zapolski, Max Zharkovsky, Alexander
Published in
The Journal of pharmacy and pharmacology
Alzheimer's disease (AD) is a neurodegenerative disorder with no cure. Limited treatment options available today do not offer solutions to slow or stop any of the suspected causes. The current medications used for the symptomatic treatment of AD include memantine and acetylcholine esterase inhibitors. Some studies suggest that melatonin could also ...
Vozella, Valentina Ahmed, Faizy Choobchian, Paoula Merrill, Collin B. Zibardi, Cristina Tarzia, Giorgio Mor, Marco Duranti, Andrea Tontini, Andrea Rivara, Silvia
...
Published in
The Journal of pharmacy and pharmacology
Objectives: URB937, a peripheral fatty acid amide hydrolase (FAAH) inhibitor, exerts profound analgesic effects in animal models. We examined, in rats, (a) the pharmacokinetic profile of oral URB937; (b) the compound’s ability to elevate levels of the representative FAAH substrate, oleoylethanolamide (OEA); and (c) the compound’s tolerability after...
Türkeş, Cüneyt
Published in
The Journal of pharmacy and pharmacology
Proton-pump inhibitors (PPIs) are drugs commonly utilized by about 7% of adults in the world. Recent researches have shown that there are countless and severe side effects of these drugs. This situation has raised concern among clinicians and patients alike. The purpose of this study is to contribute the novel drug discovery and development technol...
Miranda, Mariza A Marcato, Priscyla D Carvalho, Ivana P S Silva, Letícia B Ribeiro, Diego L Amaral, Robson Swiech, Kamilla Bastos, Jairo K Paschoal, Jonas A R Dos Reis, Rodolfo B
...
Published in
The Journal of pharmacy and pharmacology
This study proposed to use the nanotechnology to deliver glycoalkaloidic extract (AE) to bladder cancer cells, evaluating their activity in 2D and 3D models and the biological mechanism of cell death. NPs were prepared by nanoprecipitation method using polylactic acid (PLA) and characterized considering their size, charge, particle concentration an...
Akomolafe, Seun F Olasehinde, Tosin A Ogunsuyi, Opeyemi B Oyeleye, Sunday I Oboh, Ganiyu
Published in
The Journal of pharmacy and pharmacology
This study was designed to assess the role of caffeine on fertility parameters in testicular and epididymal tissues of scopolamine-induced model of amnesia in rats. Adult male rats were treated with scopolamine with or without caffeine. The modulatory effects of caffeine or scopolamine on fertility parameters were assessed in rats' testicular and e...
Wang, Jing Lu, Hong-Xia Wang, Jing
Published in
The Journal of pharmacy and pharmacology
Osteoporosis is a skeletal disease with decreased bone mass and alteration in microarchitecture of bone tissue, and these changes put patients in risk of bone fracture. As a common symptom of osteoporosis and complication of osteoporotic fracture, chronic pain is a headache for clinicians. Nonsteroidal anti-inflammatory drugs (NSAIDs), selective CO...
