Xu, Wen-Hao Wang, Han-Tao Sun, Ying Xue, Zhen-Cheng Liang, Ming-Li Su, Wei-Ke
Published in
The Journal of pharmacy and pharmacology
To investigate the antihyperuricemia and nephroprotective effects of Orthosiphon stamineus extracts on hyperuricemia (HUA) mice and explore the potential mechanisms. Orthosiphon stamineus extracts were extracted using 50% ethanol and enriched using ethyl acetate, and characterised utilising UPLC/ESI-MS. A potassium oxonate (PO) induced hyperuricemi...
Gupta, Priya Kumar, Amit Pal, Subhashis Kumar, Sachin Lahiri, Amit Kumaravelu, Jagavelu Chattopadhyay, Naibedya Dikshit, Madhu Barthwal, Manoj Kumar
Published in
The Journal of pharmacy and pharmacology
This study was undertaken to evaluate the effect of Xylocarpus moluccensis fruit fraction (F018) on the pathogenesis of collagen-induced arthritis in mice. Arthritis was induced by intradermal injection of collagen (2 mg/ml) with complete Freund's adjuvant in DBA/1J mice. F018 was administered orally at 1, 3 and 10 mg/kg for 20 days. Disease progre...
Yano, Kentaro Okabe, Chiaki Fujii, Kenta Kato, Yuko Ogihara, Takuo
Published in
The Journal of pharmacy and pharmacology
Ezrin (Ezr), radixin (Rdx) and moesin (Msn) (ERM) proteins anchor other proteins to the cell membrane, serving to regulate their localization and function. Here, we examined whether ERM proteins functionally regulate breast cancer resistance protein (BCRP) and P-glycoprotein in cell lines derived from lung, intestinal and renal cancers. ERM protein...
Su, Dan Wang, Wenbin Wu, Xinyue Li, Minyue Yan, Xuelong Hua, Zhonghong Liu, Jiahui Zhu, Zhiyu Hu, Kun Ren, Jie
...
Published in
The Journal of pharmacy and pharmacology
Meriolins, a kind of chemical hybrid between meridianins and variolins, have lately been determined as kinase inhibitors and reportedly have antitumour activity. However, there is currently no in-depth study for the action mechanism. This study aimed to elucidate the potentially antitumour action mechanism of Meriolin1 on human neuroblastoma (SH-SY...
Ur Rahman, Aziz Khan, Shahzeb Khan, Munasib
Published in
The Journal of pharmacy and pharmacology
Trans-activator of transcription (TAT), a cell penetrating peptide, has been explored to overcome resistance to penetration and transport inside the cell, therefore, suggested to be used as drug delivery vector into drug-resistant tumours. The generosity of this study was to evaluate modifiable factors (concentration, temperature, incubation time a...
Boonyong, Cherdsak Vardhanabhuti, Nontima Jianmongkol, Suree
Published in
The Journal of pharmacy and pharmacology
Indomethacin (INDO) and diclofenac (DIC) can induce intestinal cell death through induction of oxidative stress-mediated ER stress and mitochondrial dysfunction. This study investigated the cytoprotective potential of 11 polyphenols, namely caffeic acid (CAF), curcumin (CUR), epigallocatechin gallate (EGCG), gallic acid (GAL), hypophyllanthin (HYPO...
Xiang, Yongjing Zhang, Qing Wei, Shujun Huang, Cong Li, Zhengsheng Gao, Yongxiang
Published in
The Journal of pharmacy and pharmacology
Paeoniflorin, a representative pinane monoterpene glycoside in plants of Paeoniaceae family, possesses promising anticancer activities on diverse tumours. This paper summarized the advance of Paeoniflorin on cancers in vivo and in vitro, discussed the related molecular mechanisms, as well as suggested some perspectives of the future investigations....
Shi, Keru Liu, Xinyue Du, Getao Cai, Xiaoxia Zhan, Yonghua
Published in
The Journal of pharmacy and pharmacology
Britanin was explored for the antitumour effect on gastric cancer, which is a sesquiterpene lactone (SL) extracted from Inula japonica. In the present study, cell viability assays were performed to evaluate the antiproliferation effect of Britanin on gastric cancer cells. Tumour development in BGC-823 cell-bearing nude mice was monitored in real-ti...
Zha, Liqiong Wang, Beilei Qian, Jiajia Fletcher, Brock Zhang, Caiyun Dong, Qiannian Chen, Weidong Hong, Lufeng
Published in
The Journal of pharmacy and pharmacology
Zein nanoparticles (Zein NPs) were used as a hydroxyapatite (HA) biomineralization template to generate HA/Zein NPs. Doxorubicin hydrochloride (DOX) was loaded on HA/Zein NPs (HA/Zein-DOX NPs) to improve its pH-sensitive release, bioavailability and decrease cardiotoxicity. HA/Zein-DOX NPs were prepared by phase separation and biomimetic mineraliza...
Yin, Rui Zhao, Shufa Qiu, Caixia
Published in
The Journal of pharmacy and pharmacology
As one of the vital nutrient factors in central nervous system (CNS), brain-derived neurotrophic factor (BDNF) can significantly attenuate neuron damage and promote neurogenesis. Nevertheless, little research has been conducted on regulating the effect of BDNF on the inflammatory response after traumatic brain injury (TBI). In this study, we used B...
