Guo, Ziyan Xu, Jie Xia, Jianhua Wu, Zi Lei, Jiachuan Yu, Jianqing
Published in
The Journal of pharmacy and pharmacology
To explore effective extraction method and to find active constituents, we investigated the biological activity of three extracts and isolated active compounds from the fruits of Piper longum L. Three extracts from the fruits were obtained by reflux, ultrasonic and supercritical fluid extraction, respectively. Active compounds were isolated by the ...
Mokrousov, Ivan Sergeevich Perfilova, Valentina Nikolaevna Prokofiev, Igor Igorevich Popova, Tamara Alexandrovna Vodopyanova, Ekaterina Gennadievna Vasil'eva, Olga Sergeevna Tyurenkov, Ivan Nikolaevich
Published in
The Journal of pharmacy and pharmacology
The objective of this study was to investigate the effects of a new derivative of GABA, RGPU-207 compound, on the mitochondrial functions of stressed animals. RGPU-207 and the comparator drugs (phenibut and piracetam) were administered intraperitoneally to unstressed and stressed male rats at a dose of 9.4, 25 and 400 mg/kg, respectively. The oxyge...
Kaushik, Swati Tomar, Ameesha Puthanmadhom Narayanan, Susrutha Nag, Tapas Chandra Arya, Dharamvir Singh Bhatia, Jagriti
Published in
The Journal of pharmacy and pharmacology
Anti-neoplastic drug cisplatin is prescribed widely for treatment of a variety of malignancies. Its use has been restricted lately due to severe renal toxicity. The purpose of current study was to investigate the effect of pitavastatin (a hypolipidaemic drug) in cisplatin-induced acute kidney injury in rats. Male Wistar rats (150-200 g) were treate...
Qian, Jiajia Zha, Liqiong Wang, Beilei Zhang, Caiyun Hong, Lufeng Chen, Weidong
Published in
The Journal of pharmacy and pharmacology
Resveratrol (Res), a naturally occurring polyphenol, has shown pharmacological activities in treatment of liver diseases. However, the application of Res was limited by its poor bioavailability and liver targeting. Herein, 3-O-β-D-Galactosylated Resveratrol (Gal-Res) was synthesized by structural modification of Res to enhance bioavailability and l...
Caldeira, Tamires G Saúde-Guimarães, Dênia A De Lacerda, Dâmaris L R Mussel, Wagner Da Nova Yoshida, Maria Irene De Souza, Jacqueline
Published in
The Journal of pharmacy and pharmacology
To perform the polymorphic and physicochemical characterization of the potential anti-inflammatory drug, eremantholide C (EREC), as well as to evaluate the influence of these characteristics on its biopharmaceutics classification. Eremantholide C was obtained from chloroformic extract of Lychnophora trichocarpha and crystallized in two distinct sol...
Rocha, Talita Magalhães Machado, Nuno J de Sousa, João Antonio Costa Araujo, Emmanuel Vinicius Oliveira Guimaraes, Maria Adelaide Lima, David Fernandes Leite, José Roberto de Souza de Almeida Leal, Luzia Kalyne Almeida Moreira
Published in
The Journal of pharmacy and pharmacology
Epiisopiloturine (EPI) and epiisopilosine (EPIIS) are side products in the pharmaceutical industry. The present study aimed to investigate the anti-inflammatory potential of the alkaloids EPI and EPIIS in human neutrophils and mechanical hyperalgesia in mice. Neutrophils (5 × 106 cells/ml) incubated with EPI and EPIIS and stimulated by the addition...
Henze, Laura J Koehl, Niklas J O'Shea, Joseph P Kostewicz, Edmund S Holm, René Griffin, Brendan T
Published in
The Journal of pharmacy and pharmacology
In pharmaceutical drug development, preclinical tests in animal models are essential to demonstrate whether the new drug is orally bioavailable and to gain a first insight into in vivo pharmacokinetic parameters that can subsequently be used to predict human values. Despite significant advances in the development of bio-predictive in vitro models a...
Effinger, Angela O'Driscoll, Caitriona M McAllister, Mark Fotaki, Nikoletta
Published in
The Journal of pharmacy and pharmacology
Drug product performance in patients with gastrointestinal (GI) diseases can be altered compared to healthy subjects due to pathophysiological changes. In this review, relevant differences in patients with inflammatory bowel diseases, coeliac disease, irritable bowel syndrome and short bowel syndrome are discussed and possible in vitro and in silic...
Ditzinger, Felix Price, Daniel J Ilie, Alexandra-Roxana Köhl, Niklas J Jankovic, Sandra Tsakiridou, Georgia Aleandri, Simone Kalantzi, Lida Holm, René Nair, Anita
...
Published in
The Journal of pharmacy and pharmacology
This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies. An overview is provided on appropriate formulation selection by focussing on the physicochemical properties of the drug. Crystal lattice energy and the octanol-wat...
Price, Daniel J Ditzinger, Felix Koehl, Niklas J Jankovic, Sandra Tsakiridou, Georgia Nair, Anita Holm, René Kuentz, Martin Dressman, Jennifer B Saal, Christoph
...
Published in
The Journal of pharmacy and pharmacology
Supersaturating formulations hold great promise for delivery of poorly soluble active pharmaceutical ingredients (APIs). To profit from supersaturating formulations, precipitation is hindered with precipitation inhibitors (PIs), maintaining drug concentrations for as long as possible. This review provides a brief overview of supersaturation and pre...
