Looming threat of Mpox in Pakistan: Time to take urgent measures.
Published in The Journal of infection
Looming threat of Mpox in Pakistan: Time to take urgent measures.
Antibodies to PfEMP1 and variant surface antigens: Protection after controlled human malaria infection in semi-immune Ke...
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Published in The Journal of infection
Acquisition of antibodies to Plasmodium falciparum variant surface antigens (VSA) expressed on infected red blood cells (iRBCs) is associated with naturally acquired immunity to malaria. We have previously shown that antibodies to VSA on iRBCs are associated with protection against parasite growth in the context of controlled human malaria infectio...
Children with hemoglobin C or S trait have low serologic responses to a subset of malaria variant surface antigens.
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Published in The Journal of infection
Children with hemoglobin AC or AS have decreased susceptibility to clinical malaria. Parasite variant surface antigen (VSA) presentation on the surface of infected erythrocytes is altered in erythrocytes with hemoglobin C (Hb AC) or sickle trait (Hb AS) mutations in vitro. The protective role of incomplete or altered VSA presentation against clinic...
Comparative effectiveness of bivalent BA.4-5 or BA.1 mRNA booster vaccines among immunocompromised individuals across th...
Published in The Journal of infection
To estimate the effectiveness and waning of the bivalent BA.4-5 or BA.1 mRNA booster vaccine against Covid-19-related hospitalization and death in immunocompromised individuals. Nationwide analyses across Nordic countries from 1 September 2022 to 31 October 2023 using a matched cohort design. Individuals boosted with a BA.4-5 or BA.1 vaccine were m...
Indirect effectiveness of a novel SARS-COV-2 vaccine (SCB-2019) in unvaccinated household contacts in the Philippines: A...
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Published in The Journal of infection
Though observational evidence supports indirect effects of SARS-CoV-2 vaccines, randomised experiments are lacking. To address this gap, the double-blinded, prospective follow-up of the household contacts (HHCs) of Philippine participants of the individually-randomised, placebo-controlled trial of the adjuvanted-subunit protein COVID-19 vaccine, SC...
16S ribosomal RNA gene amplicons in diagnosis of infectious diseases.
Published in The Journal of infection
Frequency of antimicrobial-resistant bloodstream infections in 111 hospitals in Thailand, 2022.
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Published in The Journal of infection
To evaluate the frequency of antimicrobial-resistant bloodstream infections (AMR BSI) in Thailand. We analyzed data from 2022, generated by 111 public hospitals in health regions 1 to 12, using the AutoMated tool for Antimicrobial resistance Surveillance System (AMASS), and submitted to the Ministry of Public Health, Thailand. Multilevel Poisson re...
The IL-6 hypothesis in COVID-19: A phase 2, randomised, double-blind, placebo-controlled study to evaluate the efficacy ...
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Published in The Journal of infection
Upregulation of IL-6 has been associated with worse prognosis in COVID-19 patients. Impact on IL-6 signalling has mostly been limited to clinical outcomes in IL-6 receptor antagonist trials. We performed a phase 2, randomised, double-blind, placebo-controlled trial (NCT04380961) of US-based hospitalised adults ( 0∙05). At Day 28, 59∙4% versus 55∙0%...
Surveillance of avian influenza viruses in Hebei Province of China from 2021 to 2023: Identification of a novel reassort...
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Published in The Journal of infection
Avian influenza remains a global public health concern for its well-known point mutation and genomic segment reassortment, through which plenty of serum serotypes are generated to escape existing immune protection in animal and human populations. Some occasional cases of human infection of avian influenza viruses (AIVs) since 2020 posed a potential...
Risk of unintended consequences from lower antibiotic prescribing for respiratory tract infections in primary care.
Published in The Journal of infection
About 60% of antibiotic prescribing in primary care is for respiratory tract infections (RTIs), some of which is likely unnecessary. There is limited evidence on the association between reduced antibiotic prescribing and adverse events. We aimed to identify associations between practice-level prescribing rates for RTIs in general practice, and pati...
