Morys, Filip Dadar, Mahsa Dagher, Alain
Published in
The Journal of clinical endocrinology and metabolism
Chronic obesity is associated with several complications, including cognitive impairment and dementia. However, we have only piecemeal knowledge of the mechanisms linking obesity to central nervous system damage. Among candidate mechanisms are other elements of obesity-associated metabolic syndrome, such as hypertension, dyslipidemia, and diabetes,...
Malchoff, Carl D
Published in
The Journal of clinical endocrinology and metabolism
Wang, Xichang Gao, Xiaotong Han, Yutong Zhang, Fan Lin, Zheyu Wang, Hong Teng, Weiping Shan, Zhongyan
Published in
The Journal of clinical endocrinology and metabolism
The association between serum thyrotropin (TSH) and obesity traits has been investigated previously in several epidemiological studies. However, the underlying causal association has not been established. This work aimed to determine and analyze the causal association between serum TSH level and obesity-related traits (body mass index [BMI] and obe...
Win, Myat Beckett, Rowan Thomson, Lynn Thankamony, Ajay Beardsall, Kathy
Published in
The Journal of clinical endocrinology and metabolism
Persistent hypoglycaemia is common in the newborn and is associated with poor neurodevelopmental outcome. Adequate monitoring is critical in prevention, but is dependent on frequent, often hourly blood sampling. Continuous glucose monitoring (CGM) is increasingly being used in children with type 1 diabetes mellitus, but use in neonatology remains l...
Carlomagno, Francesco Pozza, Carlotta Tenuta, Marta Pofi, Riccardo Tarani, Luigi Sesti, Franz Minnetti, Marianna Gianfrilli, Daniele Isidori, Andrea M
Published in
The Journal of clinical endocrinology and metabolism
Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS. To analyze the testicular microcirculation...
Ward, Leanne M Choudhury, Anup Alos, Nathalie Cabral, David A Rodd, Celia Sbrocchi, Anne Marie Taback, Shayne Padidela, Raja Shaw, Nick J Hosszu, Eva
...
Published in
The Journal of clinical endocrinology and metabolism
Glucocorticoids (GC) prescribed for chronic pediatric illnesses are associated with osteoporotic fractures. To determine the efficacy and safety of intravenous (IV) zoledronic acid (ZA) compared with placebo to treat pediatric GC-induced osteoporosis (GIO). Children 5-17 years of age with GIO were enrolled in this multi-national randomized, double-...
Karczewska-Kupczewska, Monika Nikołajuk, Agnieszka Stefanowicz, Magdalena Matulewicz, Natalia Arnoriaga-Rodriguez, Maria Fernandez-Real, Jose Manuel Strączkowski, Marek
Published in
The Journal of clinical endocrinology and metabolism
Simple and reliable measurement of insulin sensitivity may be important for the prevention of insulin-resistance related diseases. Surrogate indices of insulin sensitivity are of limited utility in population without signs of metabolic syndrome. The aim of our study was to provide simple and accurate index of insulin sensitivity. The study group co...
Zayed, Ayman A Amarin, Justin Z Al-Ani, Abdallah T Altell, Tareq L Abdelhamid, Sultan S Qirem, Murad M Fahmawi, Suhib M Elshebli, Sanad M Hamo, Khair M Zaghlol, Louay Y
...
Published in
The Journal of clinical endocrinology and metabolism
Papillary thyroid carcinoma (PTC) is the most common type of nonmedullary thyroid carcinoma. Uncommonly, PTC is associated with multiple genetic alterations and chromosomal abnormalities and displays familial patterns of inheritance. Parental consanguinity increases susceptibility to many genetic disorders. This work aimed to investigate the associ...
Geberhiwot, Tarekegn
Published in
The Journal of clinical endocrinology and metabolism
Shi, Mingjian Manouchehri, Ali M Shaffer, Christian M Vaitinadin, Nataraja Sarma Hellwege, Jacklyn N Salem, Joe-Elie Davis, Lea K Simmons, Jill H Roden, Dan M Shoemaker, M Benjamin
...
Published in
The Journal of clinical endocrinology and metabolism
A genetic predisposition to lower thyrotropin (TSH) levels is associated with increased atrial fibrillation (AF) risk through undefined mechanisms. Defining the genetic mediating mechanisms could lead to improved targeted therapies to mitigate AF risk. We used 2-sample mendelian randomization (MR) to test associations between TSH-associated single-...
