Further evidence that breast milk lipids control adiposity.
Published in The Journal of clinical endocrinology and metabolism
Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus....
Published in The Journal of clinical endocrinology and metabolism
Large, longitudinal studies on androgen levels in pregnant women with polycystic ovary syndrome (PCOS) are lacking. While metformin has a mild androgen-lowering effect in non-pregnant women with PCOS, its effects on maternal androgen levels in pregnancy are less well understood. To describe androgen patterns in pregnant women with PCOS and in healt...
A Human Randomized Controlled Trial Comparing Metabolic Responses to Single and Repeated Hypoglycemia in Type 1 Diabetes...
Published in The Journal of clinical endocrinology and metabolism
Hypoglycemia hinders optimal glycemic management in type 1 diabetes (T1D). Long diabetes duration and hypoglycemia impair hormonal counter-regulatory responses to hypoglycemia. Our study was designed to test whether (1) the metabolic responses and insulin sensitivity are impaired, and (2) whether they are affected by short-lived antecedent hypoglyc...
Premature Adrenarche in Girls Characterized By Enhanced 17,20-Lyase and 17β-Hydroxysteroid Dehydrogenase Activities.
Published in The Journal of clinical endocrinology and metabolism
Girls with premature adrenarche (PA) may have a higher risk of developing polycystic ovary syndrome (PCOS) and metabolic syndrome. The biological purpose of adrenarche is unknown and the role of novel biosynthetic pathways remains unclear. To compare the urinary steroid metabolome and enzyme activities of girls with PA to age-matched control girls ...
Association Between Body Size Phenotypes and Subclinical Atherosclerosis.
...Published in The Journal of clinical endocrinology and metabolism
The underlying relationship between body mass index (BMI), cardiometabolic disorders, and subclinical atherosclerosis is poorly understood. To evaluate the association between body size phenotypes and subclinical atherosclerosis. Cross-sectional. Cardiovascular disease-free cohort. Middle-aged asymptomatic subjects (n = 3909). A total of 6 cardiome...
Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis.
Published in The Journal of clinical endocrinology and metabolism
Hyperthyroidism is associated with low levels of cholesterol and triglycerides, and hypothyroidism is associated with hypercholesterolemia and hypertriglyceridemia. The aim of this systematic review was to investigate the impact of therapy for overt and subclinical hyper- and hypothyroidism on serum lipids. We searched MEDLINE, EMBASE, the Cochrane...
Methimazole Treatment and Acute Pancreatitis: Both Caution and Reassurance Are Needed.
Published in The Journal of clinical endocrinology and metabolism
Weight Loss and Serum Lipids in Overweight and Obese Adults: A Systematic Review and Meta-Analysis.
Published in The Journal of clinical endocrinology and metabolism
Excess adipose tissue is associated with an abnormal lipid profile that may improve with weight reduction. In this meta-analysis, we aimed to estimate the magnitude of change in lipid parameters associated with weight loss in adults who are overweight or obese. We searched MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Scopus from 20...
Response to Letter to the Editor: "Approach to the Patient: Perioperative Management of the Patient With Pheochromocytom...
Published in The Journal of clinical endocrinology and metabolism
The Effects of Ivacaftor on Bone Density and Microarchitecture in Children and Adults with Cystic Fibrosis.
...Published in The Journal of clinical endocrinology and metabolism
Cystic fibrosis transmembrane conductance (CFTR) dysfunction may play a role in CF-related bone disease (CFBD). Ivacaftor is a CFTR potentiator effective in improving pulmonary and nutritional outcomes in patients with the G551D-CFTR mutation. The effects of ivacaftor on bone health are unknown. To determine the impact of ivacaftor on bone density ...
