Further evidence that breast milk lipids control adiposity.
Published in The Journal of clinical endocrinology and metabolism
Published in The Journal of clinical endocrinology and metabolism
Published in The Journal of clinical endocrinology and metabolism
Large, longitudinal studies on androgen levels in pregnant women with polycystic ovary syndrome (PCOS) are lacking. While metformin has a mild androgen-lowering effect in non-pregnant women with PCOS, its effects on maternal androgen levels in pregnancy are less well understood. To describe androgen patterns in pregnant women with PCOS and in healt...
Published in The Journal of clinical endocrinology and metabolism
Hypoglycemia hinders optimal glycemic management in type 1 diabetes (T1D). Long diabetes duration and hypoglycemia impair hormonal counter-regulatory responses to hypoglycemia. Our study was designed to test whether (1) the metabolic responses and insulin sensitivity are impaired, and (2) whether they are affected by short-lived antecedent hypoglyc...
Published in The Journal of clinical endocrinology and metabolism
Girls with premature adrenarche (PA) may have a higher risk of developing polycystic ovary syndrome (PCOS) and metabolic syndrome. The biological purpose of adrenarche is unknown and the role of novel biosynthetic pathways remains unclear. To compare the urinary steroid metabolome and enzyme activities of girls with PA to age-matched control girls ...
Published in The Journal of clinical endocrinology and metabolism
The underlying relationship between body mass index (BMI), cardiometabolic disorders, and subclinical atherosclerosis is poorly understood. To evaluate the association between body size phenotypes and subclinical atherosclerosis. Cross-sectional. Cardiovascular disease-free cohort. Middle-aged asymptomatic subjects (n = 3909). A total of 6 cardiome...
Published in The Journal of clinical endocrinology and metabolism
Hyperthyroidism is associated with low levels of cholesterol and triglycerides, and hypothyroidism is associated with hypercholesterolemia and hypertriglyceridemia. The aim of this systematic review was to investigate the impact of therapy for overt and subclinical hyper- and hypothyroidism on serum lipids. We searched MEDLINE, EMBASE, the Cochrane...
Published in The Journal of clinical endocrinology and metabolism
Published in The Journal of clinical endocrinology and metabolism
Excess adipose tissue is associated with an abnormal lipid profile that may improve with weight reduction. In this meta-analysis, we aimed to estimate the magnitude of change in lipid parameters associated with weight loss in adults who are overweight or obese. We searched MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Scopus from 20...
Published in The Journal of clinical endocrinology and metabolism
Published in The Journal of clinical endocrinology and metabolism
Cystic fibrosis transmembrane conductance (CFTR) dysfunction may play a role in CF-related bone disease (CFBD). Ivacaftor is a CFTR potentiator effective in improving pulmonary and nutritional outcomes in patients with the G551D-CFTR mutation. The effects of ivacaftor on bone health are unknown. To determine the impact of ivacaftor on bone density ...