Long, Jianyin Galvan, Daniel L Mise, Koki Kanwar, Yashpal S Li, Li Poungavrin, Naravat Overbeek, Paul A Chang, Benny H Danesh, Farhad R
Published in
The Journal of biological chemistry
Long noncoding RNAs (lncRNAs) have been shown to play key roles in a variety of biological activities of the cell. However, less is known about how lncRNAs respond to environmental cues and what transcriptional mechanisms regulate their expression. Studies from our laboratory have shown that the lncRNA Tug1 (taurine upregulated gene 1) is crucial f...
Wang, Ning Chen, Xiu-Lan Gao, Chao Peng, Ming Wang, Peng Zhang, Na Li, Fuchuan Yang, Gui-Peng Shen, Qing-Tao Li, Shengying
...
Published in
The Journal of biological chemistry
Monomethylamine (MMA) is an important climate-active oceanic trace gas and ubiquitous in the oceans. The γ-glutamylmethylamide synthetase (GmaS) catalyzes the conversion of MMA to γ-glutamylmethylamide (GMA), the first step in MMA metabolism in many marine bacteria. The gmaS gene occurs in ~23% of microbial genomes in the surface ocean and is a val...
Yadav, Manisha Singh, Ravi Shankar Hogan, Daniel Vidhyasagar, Venkatasubramanian Yang, Shizhuo Yeuk Wah Chung, Ivy Kusalik, Anthony Dmitriev, Oleg Y Cygler, Miroslaw Wu, Yuliang
...
Published in
The Journal of biological chemistry
The K-homology (KH) domain is a nucleic acid binding domain present in many proteins. Recently we found that the DEAD-box helicase DDX43 contains a KH domain in its N-terminus; however, its function remains unknown. Here, we purified recombinant DDX43 KH domain protein and found that it prefers binding single-stranded (ss)DNA and ssRNA. Electrophor...
Ren, Siqiang Breuillaud, Lionel Yao, Wen Yin, Tao Norris, Kelly A Zehntner, Simone P D'Adamio, Luciano
Published in
The Journal of biological chemistry
Alzheimer's disease is a neurodegenerative dementia associated with deposition in the central nervous system (CNS) of amyloid plaques and neurofibrillary tangles, formed by Aβ peptides and phosphor-tau, respectively. ~2% of AD cases are due to familial mutations (FAD); ~98% of cases are sporadic (SAD). FAD animal models are commonly used to study S...
Shetty, Sunil Varshney, Umesh
Published in
The Journal of biological chemistry
Protein synthesis is an energetically costly cellular activity. It is therefore important that the process of mRNA translation remains in excellent synchrony with cellular metabolism and its energy reserves. Unregulated translation could lead to the production of incomplete, mistranslated, or misfolded proteins, squandering the energy needed for ce...
Frandsen, Kristian E H Haon, Mireille Grisel, Sacha Henrissat, Bernard Lo Leggio, Leila Berrin, Jean-Guy
Published in
The Journal of biological chemistry
Understanding enzymatic breakdown of plant biomass is crucial to develop nature-inspired biotechnological processes. Lytic polysaccharide monooxygenases (LPMOs) are microbial enzymes secreted by fungal saprotrophs involved in carbon recycling. LPMOs modify biomass by oxidatively cleaving polysaccharides thereby enhancing the efficiency of glycoside...
Schulte, Jane E Roggiani, Manuela Shi, Hui Zhu, Jun Goulian, Mark
Published in
The Journal of biological chemistry
Histidine phosphorylation is a post-translational modification that alters protein function and also serves as an intermediate of phosphoryl transfer. Although phosphohistidine is relatively unstable, enzymatic dephosphorylation of this residue is apparently needed in some contexts, since both prokaryotic and eukaryotic phosphohistidine phosphatase...
Jiang, Mingyang Hu, Han Zhao, Ke Di, Ruomin Huang, Xinyi Shi, Yingchao Yue, Yunyun Nie, Junwei Yu, Shan Wang, Wengong
...
Published in
The Journal of biological chemistry
Post-transcriptional regulation of mRNA translation and stability is primarily achieved by RNA binding proteins (RBPs), which is of increasing importance for heart function. Furthermore, G-quadruplex (G4) and G4 resolvase activity are involved in a variety of biological processes. However, the role of G4 resolvase activity in heart function remains...
Bukhari, Maurish Deng, Han Sipes, Darren Ruane-Foster, Marisa Purdy, Kayla Woodworth, Craig D Sur, Shantanu Samways, Damien S K
Published in
The Journal of biological chemistry
The poor and nonselective penetration of current chemotherapeutics across the plasma membranes of cancer cells, which is necessary for the targeted disruption of the intracellular machinery, remains a major pharmaceutical challenge. In several cell types, including mast cells and macrophages, exposure to extracellular ATP is known to stimulate pass...
Strayer, Ethan C Lu, Stephen Ribeiro, Jose M Andersen, John F
Published in
The Journal of biological chemistry
Inhibition of the alternative pathway (AP) of complement by saliva from Anopheles mosquitoes facilitates feeding by blocking production of the anaphylatoxins C3a and C5a which activate mast cells leading to plasma extravasation, pain and itching. We have previously shown that albicin, a member of the SG7 protein family from An. albimanus blocks the...
