Gonzalez-Gil, Anabel Porell, Ryan N Fernandes, Steve M Maenpaa, Eila August Li, T Li, Tong Wong, Philip C Aoki, Kazuhiro Tiemeyer, Michael Yu, Zaikuan J
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Published in
The Journal of biological chemistry
Alzheimer's disease (AD) is characterized by accumulation of misfolded proteins. Genetic studies implicate microglia, brain-resident phagocytic immune cells, in AD pathogenesis. As positive effectors, microglia clear toxic proteins, whereas as negative effectors they release proinflammatory mediators. An imbalance of these functions contributes to ...
Fort, Patrice E Losiewicz, Mandy K Elghazi, Lynda Kong, Dejuan Cras-Méneur, Corentin Fingar, Diane C Kimball, Scot R Rajala, Raju V S Smith, Alexander J Ali, Robin R
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Published in
The Journal of biological chemistry
Mechanistic target of rapamycin (mTOR) and members of mTOR complex 1 (mTORC1), a linchpin of the nutrient sensing and protein synthesis pathways, are present at relatively high levels in the ganglion cell layer (GCL) and retinal ganglion cells (RGC) of rodent and human retinas. However, the role of mTOR complexes in the control of protein synthesis...
Zhou, Qing Hu, Huiqing Li, Ziyin
Published in
The Journal of biological chemistry
Cytokinesis in the early divergent protozoan Trypanosoma brucei occurs from the anterior cell tip of the new-flagellum daughter towards the nascent posterior end of the old-flagellum daughter of a dividing bi-flagellated cell. The cleavage furrow ingresses uni-directionally along the pre-formed cell division fold, and is regulated by an orphan kine...
Cai, David Brickey, Willie June Ting, Jenny P Sad, Subash
Published in
The Journal of biological chemistry
He, Jingxuan Zou, Ling-Nan Pareek, Vidhi Benkovic, Stephen J
Published in
The Journal of biological chemistry
There is growing evidence that mammalian cells deploy a mitochondria-associated metabolon called the purinosome to perform channeled de novo purine biosynthesis (DNPB). However, the molecular mechanisms of this substrate-channeling pathway are not well defined. Here, we present molecular evidence of protein-protein interactions (PPIs) between the h...
Wan, Hanxing Chen, Xiong Ying Zhang, Fenglian Chen, Jun Chu, Fenglan Sellers, Zachary M Xu, Feng Dong, Hui
Published in
The Journal of biological chemistry
Although capsaicin has been studied extensively as an activator of the transient receptor potential vanilloid cation channel subtype 1 (TRPV1) channels in sensory neurons, little is known about its TRPV1-independent actions in gastrointestinal health and disease. Here, we aimed to investigate the pharmacological actions of capsaicin as a food addit...
Sagae, Takeru Yokogawa, Mariko Sawazaki, Ryoichi Ishii, Yuichiro Hosoda, Nao Hoshino, Shin-Ichi Imai, Shunsuke Shimada, Ichio Osawa, Masanori
Published in
The Journal of biological chemistry
Eukaryotic mRNAs possess a poly(A) tail at their 3'-end, to which poly(A)-binding protein C1 (PABPC1) binds and recruits other proteins that regulate translation. Enhanced poly(A)-dependent translation, which is also PABPC1 dependent, promotes cellular and viral proliferation. PABP-interacting protein 2A (Paip2A) effectively represses poly(A)-depen...
Lockey, Christine Young, Hannah Brown, Jessica Dixon, Ann M
Published in
The Journal of biological chemistry
The B-cell receptor (BCR), a complex comprised of a membrane-associated immunoglobulin and the Igα/β heterodimer, is one of the most important immune receptors in humans and controls B-cell development, activity, selection, and death. BCR signaling plays key roles in autoimmune diseases and lymphoproliferative disorders, yet, despite the clinical s...
Thirouin, Zahra S Figueiredo, Marta Hleihil, Mohammad Gill, Raminder Bosshard, Giovanna McKinney, R Anne Tyagarajan, Shiva K
Published in
The Journal of biological chemistry
Posttranslational addition of a small ubiquitin-like modifier (SUMO) moiety (SUMOylation) has been implicated in pathologies such as brain ischemia, diabetic peripheral neuropathy, and neurodegeneration. However, nuclear enrichment of SUMO pathway proteins has made it difficult to ascertain how ion channels, proteins that are typically localized to...
Thines, Louise Gorisse, Laëtitia Li, Zhigang Sayedyahossein, Samar Sacks, David B
Published in
The Journal of biological chemistry
The Hippo signaling pathway regulates tissue growth and cell fate, and its dysregulation can induce tumorigenesis. When Hippo is activated by cell-cell contact, extracellular signals, or cell polarity among others, the large tumor suppressor 1 (LATS1) kinase catalyzes inhibitory phosphorylation of the transcriptional coactivator Yes-associated prot...
