Carla Guarino, Seren, Seda Lemoine, Roxane Hummel, AmberM Margotin, Jean-Edouard El-Benna, Jamel Hoarau, Cyrille Specks, Ulrich Jenne, DieterE Korkmaz, Brice
...
Published in
The Journal of biological chemistry
Proteinase 3 (PR3) is the main target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in PR3-ANCA-associated vasculitis. A small fraction of PR3 is constitutively exposed on the surface of quiescent blood neutrophils in a proteolytically inactive form. When activated, neutrophils expose an induced form of membrane-bound PR3 (PR3mb) on thei...
Thomes, Paul G Strupp, Michael S Donohue, Terence M Jr Kubik, Jacy L Sweeney, Sarah Mahmud, R Schott, Micah B Schulze, Ryan J McNiven, Mark A Casey, Carol A
...
Published in
The Journal of biological chemistry
Lipid Droplets (LDs) are fat-storing organelles enclosed by a phospholipid monolayer, which harbors membrane-associated proteins that regulate distinct LD functions. LD proteins are degraded by the ubiquitin-proteasome system (UPS) and/or by lysosomes. Because chronic ethanol (EtOH) consumption diminishes the hepatic functions of the UPS and lysoso...
Zhao, Zitong Pan, Teng Chen, Shen Harvey, PetaJ Zhang, Jinghui Li, Xiao Yang, Mengke Huang, Linhong Wang, Shoushi Craik, DavidJ
...
Published in
The Journal of biological chemistry
μ-Conotoxin KIIIA, a selective blocker of sodium channels, has strong inhibitory activity against several Nav isoforms, including Nav1.7, and has potent analgesic effects, but it contains three pairs of disulfide bonds, making structural modification difficult and synthesis complex. To circumvent these difficulties, we designed and synthesized thre...
Chiang, JohnY L
Published in
The Journal of biological chemistry
It is a great honor to be invited to write a reflection of my lifelong bile acid research for the Journal of Biological Chemistry, the premier biochemistry journal in which I am proud to have published 24 manuscripts. I published 21 manuscripts in the Journal of Lipid Research, also a journal of American Society of Biochemistry and Molecular Biolog...
Faraj, Santiago E Valsecchi, Wanda M Ferreira-Gomes, Mariela Centeno, Mercedes Saint Martin, Elina Malѐn Fedosova, Natalya U Rossi, Juan Pablo Fc Montes, MÓnica R Rossi, Rolando C
Published in
The Journal of biological chemistry
The Na+/K+-ATPase is an integral plasma membrane glycoprotein of all animal cells that couples the exchange of intracellular Na+ for extracellular K+ to the hydrolysis of ATP. The asymmetric distribution of Na+ and K+ is essential for cellular life and constitutes the physical basis of a series of fundamental biological phenomena. The pumping mecha...
Wang, Wenjuan Zhang, Zhaohan Zhao, Minghui Wang, Yu Ge, Yuze Shan, Lin
Published in
The Journal of biological chemistry
CXXC5, a member of the CXXC family of zinc-finger proteins, is associated with numerous pathological processes. However, the pathophysiological function of CXXC5 has not been clearly established. Herein, we found that CXXC5 interacts with the CRL4B and NuRD complexes. Screening of transcriptional targets downstream of the CXXC5-CRL4B-NuRD complex b...
Yin, Terry C Mittal, Ayushi Buscaglia, Paul Li, Wenxian Sebag, Julien A
Published in
The Journal of biological chemistry
The regulation of energy homeostasis is a complex system involving multiple hormones, neuropeptides, and receptors. Prokineticins (PK1 and PK2) are agonists to two GPCRs, Prokineticin receptor 1 and 2 (PKR1 and PKR2), which decrease food intake when injected in rodents. The relative contribution of PKR1 and PKR2 to the anorexigenic effect of PK2 an...
Rangarajan, Erumbi S Smith, Emmanuel W Izard, Tina
Published in
The Journal of biological chemistry
The regulation of cell-cell junctions during epidermal morphogenesis ensures tissue integrity, a process regulated by α-catenin. This cytoskeletal protein connects the cadherin complex to filamentous actin at cell-cell junctions. The cadherin-catenin complex plays key roles in cell physiology, organism development, and disease. While mutagenesis of...
Higerd-Rusli, Grant P Tyagi, Sidharth Liu, Shujun Dib-Hajj, Fadia B Waxman, Stephen G Dib-Hajj, Sulayman D
Published in
The Journal of biological chemistry
Neuronal function relies on the maintenance of appropriate levels of various ion channels at the cell membrane, which is accomplished by balancing secretory, degradative, and recycling pathways. Neuronal function further depends on membrane specialization through polarized distribution of specific proteins to distinct neuronal compartments such as ...
Young-Baird, Sara K
Published in
The Journal of biological chemistry
Loss of function of the RNA-binding protein FMRP causes fragile X syndrome, the most common inherited form of intellectual disability and autism spectrum disorders. FMRP is suggested to modulate synaptic plasticity by regulating the synthesis of proteins involved in neuronal and synaptic function; however, the mechanism underlying FMRP mRNA targeti...
