Reply.
Published in The Journal of allergy and clinical immunology
Mutual regulation of metabolic processes and proinflammatory NF-κB signaling.
Published in The Journal of allergy and clinical immunology
The nuclear factor kappa B (NF-κB) signaling system, a key regulator of immunologic processes, also affects a plethora of metabolic changes associated with inflammation and the immune response. NF-κB-regulating signaling cascades, in concert with NF-κB-mediated transcriptional events, control the metabolism at several levels. NF-κB modulates apical...
Long-term follow-up of 168 patients with X-linked agammaglobulinemia reveals increased morbidity and mortality.
...Published in The Journal of allergy and clinical immunology
X-linked agammaglobulinemia (XLA) is the prototype of primary humoral immunodeficiencies. Long-term follow-up studies regarding disease-related complications and outcome are scarce. Our aim was to describe the natural history of XLA. A nationwide multicenter study based on the Italian Primary Immunodeficiency Network registry was established in 200...
Neonatal thymectomy in children-accelerating the immunologic clock?
Published in The Journal of allergy and clinical immunology
The thymus is critical for central tolerance and diverse T-lymphocyte repertoire development, to provide lifelong defense against pathogens while maintaining self-tolerance. Peak thymic output occurs in utero, during infancy, and in early childhood, diminishing throughout life. Infants with congenital heart disease requiring sternotomy often underg...
Glycolipid-mediated basophil activation in alpha-gal allergy.
...Published in The Journal of allergy and clinical immunology
Optimal identification of human conventional and nonconventional (CRTH2-IL7Rα-) ILC2s using additional surface markers.
...Published in The Journal of allergy and clinical immunology
Human type 2 innate lymphoid cells (ILC2s) are identified by coupled detection of CRTH2 and IL7Rα on lineage negative (Lin-) cells. Type 2 cytokine production by CRTH2-IL7Rα- innate lymphoid cells (ILCs) is unknown. We sought to identify CRTH2-IL7Rα- type 2 cytokine-producing ILCs and their disease relevance. We studied human blood and lung ILCs fr...
Anti-Saccharomyces cerevisiae IgG and IgA antibodies are associated with systemic inflammation and advanced disease in h...
...Published in The Journal of allergy and clinical immunology
Plasma protein profiling reflects TH1-driven immune dysregulation in common variable immunodeficiency.
Published in The Journal of allergy and clinical immunology
Common variable immunodeficiency (CVID) is a disorder characterized by antibody deficiency. A significant fraction of the patients suffer from immune dysregulation, which leads to increased morbidity and mortality. The pathogenesis of this condition is poorly understood. Our aim was to find out whether the plasma protein signature in CVID is associ...
Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulog...
Published in The Journal of allergy and clinical immunology
The human eosinophil Charcot-Leyden crystal (CLC) protein is a member of the Galectin superfamily and is also known as galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals that are considered hallmarks of eosinophil participation in allergic responses and related inflammatory reactions; however, the glycan-containin...
Does asthma affect morbidity or severity of COVID-19?
Published in The Journal of allergy and clinical immunology
