Kaneko, Kazuyo Zaitoun, Abed M Letley, Darren P Rhead, Joanne L Torres, Javier Spendlove, Ian Atherton, John C Robinson, Karen
Published in
The Journal of Pathology
High‐level expression of decay‐accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicobacter pylori infection and virulence factors in the induction of CD55 and its association with histo...
Samsom, Kris G Schipper, Luuk J Roepman, Paul Bosch, Linda JW Lalezari, Ferry Klompenhouwer, Elisabeth G de Langen, Adrianus J Buffart, Tineke E Riethorst, Immy Schoenmaker, Lieke
...
Published in
The Journal of Pathology
The current increase in number and diversity of targeted anticancer agents poses challenges to the logistics and timeliness of molecular diagnostics (MolDx), resulting in underdiagnosis and treatment. Whole‐genome sequencing (WGS) may provide a sustainable solution for addressing current as well as future diagnostic challenges. The present study th...
Qi, Wenqing Rosikiewicz, Wojciech Yin, Zhaohong Xu, Beisi Jiang, Huihong Wan, Shibiao Fan, Yiping Wu, Gang Wang, Lu
Published in
The Journal of pathology
Mesenchymal chondrosarcoma is a rare, high-grade, primitive mesenchymal tumor. It accounts for around 2-10% of all chondrosarcomas and mainly affects adolescents and young adults. We previously described the HEY1-NCOA2 as a recurrent gene fusion in mesenchymal chondrosarcoma, an important breakthrough for characterizing this disease; however, littl...
Ghosh, Arnab Das, Chitrarpita Ghose, Sandip Maitra, Arindam Roy, Bidyut Majumder, Partha P Biswas, Nidhan K
Published in
The Journal of pathology
A thickened, white patch - leukoplakia - in the oral cavity is usually benign, but sometimes (in ~9% of individuals) it progresses to malignant tumour. Because the genomic basis of this progression is poorly understood, we undertook this study and collected samples of four tissues - leukoplakia, tumour, adjacent normal, and blood - from each of 28 ...
van den Bosch, Tom Miedema, Daniël M Vermeulen, Louis
Published in
The Journal of pathology
Overall, the prognosis of patients suffering from stage II colon cancer is relatively favorable. However, a proportion of patients develop a recurrence following surgery. Clinical and histopathological properties that identify high-risk patients are of limited value and better biomarkers are urgently required. In a recent issue of The Journal of Pa...
Megyesfalvi, Zsolt Barany, Nandor Lantos, Andras Valko, Zsuzsanna Pipek, Orsolya Lang, Christian Schwendenwein, Anna Oberndorfer, Felicitas Paku, Sandor Ferencz, Bence
...
Published in
The Journal of pathology
The tissue distribution and prognostic relevance of subtype-specific proteins (ASCL1, NEUROD1, POU2F3, YAP1) present an evolving area of research in small-cell lung cancer (SCLC). The expression of subtype-specific transcription factors and P53 and RB1 proteins were measured by immunohistochemistry (IHC) in 386 surgically resected SCLC samples. Cor...
Pagano, Francesca Picchio, Vittorio Bordin, Antonella Cavarretta, Elena Nocella, Cristina Cozzolino, Claudia Floris, Erica Angelini, Francesco Sordano, Alessia Peruzzi, Mariangela
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Published in
The Journal of Pathology
Cardiac stromal cells (CSCs) are the main players in fibrosis. Dysmetabolic conditions (metabolic syndrome—MetS, and type 2 diabetes mellitus—DM2) are strong pathogenetic contributors to cardiac fibrosis. Moreover, modulation of the oxidative state (OxSt) and autophagy is a fundamental function affecting the fibrotic commitment of CSCs, that are ad...
Bekkhus, Tove Avenel, Christophe Hanna, Sabella Franzén Boger, Mathias Klemm, Anna H Vasiliu-Bacovia, Daniel Wärnberg, Fredrik Wählby, Carolina Ulvmar, Maria H.
Vascular remodeling is common in human cancer and has potential as future biomarkers for prediction of disease progression and tumor immunity status. It can also affect metastatic sites, including the tumor-draining lymph nodes (TDLNs). Dilation of the high endothelial venules (HEVs) within TDLNs has been observed in several types of cancer. We rec...
Gabbutt, Calum Wright, Nicholas A Baker, Ann-Marie Shibata, Darryl Graham, Trevor A
Published in
The Journal of pathology
The dynamical process of cell division that underpins homeostasis in the human body cannot be directly observed in vivo, but instead is measurable from the pattern of somatic genetic or epigenetic mutations that accrue in tissues over an individual's lifetime. Because somatic mutations are heritable, they serve as natural lineage tracing markers th...
Viswanathan, Vidya Sankar Toro, Paula Corredor, Germán Mukhopadhyay, Sanjay Madabhushi, Anant
Published in
The Journal of pathology
Lung diseases carry a significant burden of morbidity and mortality worldwide. The advent of digital pathology (DP) and an increase in computational power have led to the development of artificial intelligence (AI)-based tools that can assist pathologists and pulmonologists in improving clinical workflow and patient management. While previous works...
