Pavlič, Ana Boštjančič, Emanuela Kavalar, Rajko Ilijevec, Bojan Bonin, Serena Zanconati, Fabrizio Zidar, Nina
Published in
The Journal of pathology
Morphological features including infiltrative growth, tumour budding (TB), and poorly differentiated clusters (PDCs) have a firmly established negative predictive value in colorectal cancer (CRC). Despite extensive research, the mechanisms underlying different tumour growth patterns remain poorly understood. The aim of this study was to investigate...
Ter Steege, Eline J Boer, Mandy Timmer, Nikki C Ammerlaan, Carola Me Song, Ji-Ying Derksen, Patrick Wb Hilkens, John Bakker, Elvira Rm
Published in
The Journal of pathology
R-spondins (RSPOs) are influential signaling molecules that promote the Wnt/β-catenin pathway and self-renewal of stem cells. Currently, RSPOs are emerging as clinically relevant oncogenes, being linked to cancer development in multiple organs. Although this has instigated the rapid development and testing of therapeutic antibodies targeting RSPOs,...
Kamp, Eline Jca Dinjens, Winand Nm Doukas, Michail van Marion, Ronald Verheij, Joanne Ponsioen, Cyriel Y Bruno, Marco J Groot Koerkamp, Bas Trivedi, Palak J Peppelenbosch, Maikel P
...
Published in
The Journal of pathology
Carcinogenesis of primary sclerosing cholangitis (PSC)-associated cholangiocarcinoma (CCA) is largely unexplored. Improved understanding of the molecular events involved may guide development of novel avenues for rational clinical management. We aimed to assess the genetic alterations during progression of the neoplastic cascade from biliary dyspla...
Vázquez-Carballo, Cristina Herencia, Carmen Guerrero-Hue, Melania García-Caballero, Cristina Rayego-Mateos, Sandra Morgado-Pascual, José Luis Opazo-Rios, Lucas González-Guerrero, Cristian Vallejo-Mudarra, Mercedes Cortegano, Isabel
...
Published in
The Journal of pathology
Massive intravascular hemolysis is a common characteristic of several pathologies. It is associated with the release of large quantities of heme into the circulation, promoting injury in vulnerable organs, mainly kidney, liver, and spleen. Heme activates Toll-like receptor 4 (TLR4), a key regulator of the inflammatory response; however, the role of...
Rifai, Olivia M Longden, James O'Shaughnessy, Judi Sewell, Michael DE Pate, Judith McDade, Karina Daniels, Michael JD Abrahams, Sharon Chandran, Siddharthan McColl, Barry W
...
Published in
The Journal of Pathology
Clinical heterogeneity observed across patients with amyotrophic lateral sclerosis (ALS) is a known complicating factor in identifying potential therapeutics, even within cohorts with the same mutation, such as C9orf72 hexanucleotide repeat expansions (HREs). Thus, further understanding of pathways underlying this heterogeneity is essential for app...
Namikawa, Ken Tanaka, Norio Ota, Yuki Takamatsu, Manabu Kosugi, Mayuko Tokai, Yoshitaka Yoshimizu, Shoichi Horiuchi, Yusuke Ishiyama, Akiyoshi Yoshio, Toshiyuki
...
Published in
The Journal of Pathology
Helicobacter pylori (HP) is a major etiologic driver of diffuse‐type gastric cancer (DGC). However, improvements in hygiene have led to an increase in the prevalence of HP‐naïve DGC; that is, DGC that occurs independent of HP. Although multiple genomic cohort studies for gastric cancer have been conducted, including studies for DGC, distinctive gen...
Kim, Jung Tae Lim, Mi Ae Lee, Seong Eun Kim, Hyun Jung Koh, Hyun Yong Lee, Jeong Ho Jun, Sang Mi Kim, Jin Man Kim, Kun Ho Shin, Hyo Shik
...
Published in
The Journal of Pathology
Thyroid cancer is associated with genetic alterations, e.g. BRAFV600E, which may cause carcinomatous changes in hormone‐secreting epithelial cells. Epidemiological studies have shown that overnutrition is related to the development and progression of cancer. In this study, we attempted to identify the cell nonautonomous factor responsible for the p...
Khalique, Saira Nash, Sarah Natrajan, Rachael
Published in
The Journal of pathology
The ARID1A tumour suppressor protein is a component of the SWI/SNF chromatin remodelling complex, which is mutated in approximately 20% of all human cancers. ARID1A mutational status is considered to hold prognostic significance in a range of solid malignancies, yet in endometriosis-related ovarian carcinomas there has been a lack of clarity of its...
Bueno-Martínez, Elena Sanoguera-Miralles, Lara Valenzuela-Palomo, Alberto Esteban-Sánchez, Ada Lorca, Víctor Llinares-Burguet, Inés Allen, Jamie García-Álvarez, Alicia Pérez-Segura, Pedro Durán, Mercedes
...
Published in
The Journal of pathology
The ataxia telangiectasia-mutated (ATM) protein is a major coordinator of the DNA damage response pathway. ATM loss-of-function variants are associated with 2-fold increased breast cancer risk. We aimed at identifying and classifying spliceogenic ATM variants detected in subjects of the large-scale sequencing project BRIDGES. A total of 381 variant...
Madison, Jacob Wilhelm, Kevin Meehan, Daniel T Delimont, Duane Samuelson, Gina Cosgrove, Dominic
Published in
The Journal of pathology
In Alport mice, activation of the endothelin A receptor (ETA R) in mesangial cells results in sub-endothelial invasion of glomerular capillaries by mesangial filopodia. Filopodia deposit mesangial matrix in the glomerular basement membrane (GBM), including laminin 211 which activates NF-κB, resulting in induction of inflammatory cytokines. Herein w...
