Anglesio, Michael S Bashashati, Ali Wang, Yi Kan Senz, Janine Ha, Gavin Yang, Winnie Aniba, Mohamed R Prentice, Leah M Farahani, Hossein Li Chang, Hector
...
Published in
The Journal of pathology
Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole-genome shotgun sequencing of seven clear cell ovarian carcinomas (CCC) and targeted sequencing in synchronous endometriosis, we have investigated how this carcinoma may evolve from endometriosis. I...
Weren, Robbert D A Venkatachalam, Ramprasath Cazier, Jean-Baptiste Farin, Henner F Kets, C Marleen de Voer, Richarda M Vreede, Lilian Verwiel, Eugène T P van Asseldonk, Monique Kamping, Eveline J
...
Published in
The Journal of pathology
Heritable genetic variants can significantly affect the lifetime risk of developing cancer, including polyposis and colorectal cancer (CRC). Variants in genes currently known to be associated with a high risk for polyposis or CRC, however, explain only a limited number of hereditary cases. The identification of additional genetic causes is, therefo...
van den Brand, Judith M A Smits, Saskia L Haagmans, Bart L
Published in
The Journal of pathology
Human coronaviruses (CoVs) mostly cause a common cold that is mild and self-limiting. Zoonotic transmission of CoVs such as the recently identified Middle East respiratory syndrome (MERS)-CoV and severe acute respiratory syndrome (SARS)-CoV, on the other hand, may be associated with severe lower respiratory tract infection. This article reviews the...
Herrington, C S Coates, P J Duprex, W P
Published in
The Journal of pathology
Viruses cause a wide range of human diseases, ranging from acute self-resolving conditions to acute fatal diseases. Effects that arise long after the primary infection can also increase the propensity for chronic conditions or lead to the development of cancer. Recent advances in the fields of virology and pathology have been fundamental in improvi...
Laouirem, Samira Le Faouder, Julie Alexandrov, Theodore Mestivier, Denis Léger, Thibaut Baudin, Xavier Mebarki, Mouniya Valérie Paradis Jean-Michel Camadro Bedossa, Pierre
...
Published in
The Journal of Pathology
Cirrhosis is a lesion at risk of hepatocellular carcinoma (HCC). Identifying mechanisms associated with the transition from cirrhosis to HCC and characterizing biomarkers of cirrhosis at high risk of developing into cancer are crucial for improving early diagnosis and prognosis of HCC. We used MALDI imaging to compare mass spectra obtained from tis...
Bardella, Chiara El-Bahrawy, Mona Frizzell, Norma Adam, Julie Ternette, Nicola Hatipoglu, Emine Howarth, Kimberley O'Flaherty, Linda Roberts, Ian Turner, Gareth
...
Published in
The Journal of pathology
Germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. FH-deficient cells and tissues accumulate high levels of fumarate, which may act as an oncometabolite and contribute to tumourigenesis. A recently proposed role for fumarate in the cova...
Peter, Martine Stransky, Nicolas Couturier, Jérôme Hupé, Philippe Barillot, Emmanuel Patricia De Cremoux Cottu, Paul Radvanyi, Francois Sastre-Garau, Xavier
Published in
The Journal of Pathology
To investigate whether integration of HPV DNA in cervical carcinoma is responsible for structural alterations of the host genome at the insertion site, a series of 34 primary cervical carcinomas and eight cervical cancer-derived cell lines were analysed. DNA copy number profiles were assessed using the Affymetrix GeneChip Human Mapping 250K Sty arr...
Ahmed, Ahmed Ashour Etemadmoghadam, Dariush Temple, Jillian Lynch, Andy G Riad, Mohamed Sharma, Raghwa Stewart, Colin Fereday, Sian Caldas, Carlos Defazio, Anna
...
Published in
The Journal of pathology
Numerous studies have tested the association between TP53 mutations in ovarian cancer and prognosis but these have been consistently confounded by limitations in study design, methodology, and/or heterogeneity in the sample cohort. High-grade serous (HGS) carcinoma is the most clinically important histological subtype of ovarian cancer. As these tu...
Franck Bourdeaut Janoueix-Lerosey, Isabelle Lucchesi, Carlo Paris, Régine Ribeiro, Agnès de Pontual, Loïc Amiel, Jeanne Stanislas Lyonnet Pierron, Gaëlle Michon, Jean
...
Published in
The Journal of Pathology
The morphology of malignant cells distinguishes between undifferentiated, poorly differentiated and differentiating neuroblastomas and constitutes a strong prognostic factor. Spontaneous or treatment-induced maturation characterizes a subset of neuroblastomas. It constitutes the basis of retinoic acid treatment to improve survival in aggressive neu...
Cavard, Catherine Audebourg, Anne Letourneur, Franck Audard, Virginie Beuvon, Frédéric Cagnard, Nicolas Radenen, Brigitte Varlet, Pascale Vacher-Lavenu, Marie-Cécile Christine Perret
...
Published in
The Journal of Pathology
Solid-pseudopapillary neoplasms (SPNs) are rare human pancreatic neoplasms usually associated with a good prognosis. In contrast to other pancreatic tumours, aberrant activation of the Wnt-beta-catenin pathway appears to be a constant feature in SPN. Aside from activation of the Wnt-beta-catenin pathway, little is known about biological pathways de...
