Eyck, Ben M Jansen, Maurice Phm Noordman, Bo Jan Atmodimedjo, Peggy N van der Wilk, Berend J Martens, John Wm Helmijr, Jean A Beaufort, Corine M Mostert, Bianca Doukas, Michail
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Published in
The Journal of pathology
Active surveillance instead of standard surgery after neoadjuvant chemoradiotherapy (nCRT) has been proposed for patients with oesophageal cancer. Circulating tumour DNA (ctDNA) may be used to facilitate selection of patients for surgery. We show that detection of ctDNA after nCRT seems highly suggestive of major residual disease. Tumour biopsies a...
Gu, Xiaolian Wang, Lixiao Coates, Philip J Gnanasundram, Sivakumar Vadivel Sgaramella, Nicola Sörlin, Jonas Erdogan, Baris Magan, Mustafa Nylander, Karin
Published in
The Journal of pathology
Oral cancer is a paradigm of Slaughter's concept of field cancerization, where tumors are thought to originate within an area of cells containing genetic alterations that predispose to cancer development. The field size is unclear but may represent a large area of tissue, and the origin of mutations is also unclear. Here, we analyzed whole exome an...
Celada, Lucía Cubiella, Tamara San-Juan-Guardado, Jaime Gutiérrez, Gala Beiguela, Brenda Rodriguez, Raúl Poch, María Astudillo, Aurora Grijalba, Ana Sánchez-Sobrino, Paula
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Published in
The Journal of pathology
Metastatic pheochromocytoma and paraganglioma (PPGL) have poor prognosis and limited therapeutic options. The recent advent of immunotherapies showing remarkable clinical efficacies against various cancer types offers the possibility of novel opportunities also for metastatic PPGL. Most PPGLs are pathogenically linked to inactivating mutations in g...
Posner, Atara Prall, Owen Wj Sivakumaran, Tharani Etemadamoghadam, Dariush Thio, Niko Pattison, Andrew Balachander, Shiva Fisher, Krista Webb, Samantha Wood, Colin
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Published in
The Journal of pathology
Cancer of unknown primary (CUP) is a syndrome defined by clinical absence of a primary cancer after standardised investigations. Gene expression profiling (GEP) and DNA sequencing have been used to predict primary tissue of origin (TOO) in CUP and find molecularly guided treatments; however, a detailed comparison of the diagnostic yield from these ...
López-Janeiro, Álvaro Villalba-Esparza, María Brizzi, María Emilia Jiménez-Sánchez, Daniel Ruz-Caracuel, Ignacio Kadioglu, Ece Masetto, Ivan Goubert, Virginie Garcia-Ros, David Melero, Ignacio
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Published in
The Journal of pathology
Endometrial tumors show substantial heterogeneity in their immune microenvironment. This heterogeneity could be used to improve the accuracy of current outcome prediction tools. We assessed the immune microenvironment of 235 patients diagnosed with low-grade, early-stage endometrial cancer. Multiplex quantitative immunofluorescence was carried out ...
Neuzillet, Cindy Nicolle, Rémy Raffenne, Jérôme Tijeras-Raballand, Annemilaï Brunel, Alexia Astorgues-Xerri, Lucile Vacher, Sophie Arbateraz, Floriane Fanjul, Marjorie Hilmi, Marc
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Published in
The Journal of pathology
Cancer-associated fibroblasts (CAFs) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Previously we described four CAF subtypes with specific molecular and functional features. Here, we have refined our CAF subtype signatures using RNAseq and immunostaining with the goal of defining bioinformatically the phenotypic...
Tibarewal, Priyanka Rathbone, Victoria Constantinou, Georgia Pearce, Wayne Adil, Mahreen Varyova, Zofia Folkes, Lisa Hampson, Alix Classen, Gala Anastasia Electra Alves, Adriana
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Published in
The Journal of pathology
PTEN is one of the most commonly inactivated tumour suppressor genes in sporadic cancer. Germline heterozygous PTEN gene alterations also underlie PTEN hamartoma tumour syndrome (PHTS), a rare human cancer-predisposition condition. A key feature of systemic PTEN deregulation is the inability to adequately dampen PI3-kinase (PI3K)/mTORC1 signalling....
Lu, Jun Duan, Yumei Liu, Pinbo He, Xiang Yang, Yiping Zhang, Ran Weng, Liang
Published in
The Journal of Pathology
Lung squamous cell carcinoma (LUSC) is a primary subtype of lung cancer with limited therapeutic options and poor prognosis, and tumour‐infiltrating myeloid cells (TIMs) are key regulators of LUSC. However, the correlation between the abundance of TIM subtypes and clinical outcomes of LUSC remains unexplored. This study aimed to develop and validat...
Birkeälv, Sofia Harland, Mark Matsuyama, Larissa Satiko Alcantara Seki... Rashid, Mamun Mehta, Ishan Laye, Jonathan P Haase, Kerstin Mell, Tracey Iyer, Vivek Robles‐Espinoza, Carla Daniela
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Published in
The Journal of Pathology
Melanoma is a heterogenous malignancy with an unpredictable clinical course. Most patients who present in the clinic are diagnosed with primary melanoma, yet large‐scale sequencing efforts have focused primarily on metastatic disease. In this study we sequence‐profiled 524 American Joint Committee on Cancer Stage I–III primary tumours. Our analysis...
Lucas, Sebastian
Published in
The Journal of pathology
SARS-CoV-2 virus, the cause of COVID-19 disease, establishes infection in the human body via interaction with the angiotensin-converting enzyme 2 (ACE2) receptor on cell membranes. The lung is the major organ affected, and all respiratory epithelium from nose to alveolus is infectable. A recent study published in The Journal of Pathology looked at ...
