Vanchin, Byambasuren Offringa, Emma Friedrich, Julian Brinker, Marja Gl Kiers, Bianca Pereira, Alexandre C Harmsen, Martin C Moonen, Jan-Renier Aj Krenning, Guido
Published in
The Journal of pathology
Endothelial-mesenchymal transition occurs during intimal hyperplasia and neointima formation via mechanisms that are incompletely understood. Endothelial MAPK7 signaling is a key mechanosensitive factor that protects against endothelial-mesenchymal transition, but its signaling activity is lost in vessel areas that are undergoing pathological remod...
Voisin, Mathieu-Benoit Nourshargh, Sussan
Published in
The Journal of pathology
Recent advances have provided evidence for the involvement of neutrophils in both innate and adaptive immunity, robustly challenging the old dogma that neutrophils are short-lived prototypical innate immune cells solely involved in acute responses to microbes and exerting collateral tissue damage. There is now ample evidence showing that neutrophil...
Pertiwi, Kartika R de Boer, Onno J Mackaaij, Claire Pabittei, Dara R de Winter, Robbert J Li, Xiaofei van der Wal, Allard C
Published in
The Journal of pathology
Extracellular traps generated by neutrophils contribute to thrombus progression in coronary atherosclerotic plaques. It is not known whether other inflammatory cell types in coronary atherosclerotic plaque or thrombus also release extracellular traps. We investigated their formation by macrophages, mast cells, and eosinophils in human coronary athe...
Lam, Wai Kei Jacky Chan, Kwan Chee Allen Lo, Yuk Ming Dennis
Published in
The Journal of pathology
Analysis of circulating tumour DNA (ctDNA), as one type of 'liquid biopsy', has recently attracted great attention. Researchers are exploring many potential applications of liquid biopsy in many different types of cancer. In particular, it is of biological interest and clinical relevance to study the molecular characteristics of ctDNA. For such pur...
Ashley, Neil Ouaret, Djamila Bodmer, Walter F
Published in
The Journal of pathology
Colonic epithelial cells are highly polarised with a lumen-facing apical membrane, termed the brush border, and a basal membrane in contact with the underlying extracellular matrix (ECM). This polarity is often maintained in cancer tissue in the form of neoplastic glands and has prognostic value. We compared the cellular polarity of several ex vivo...
Jandl, Katharina Thekkekara Puthenparampil, Helene Marsh, Leigh M Hoffmann, Julia Wilhelm, Jochen Veith, Christine Sinn, Katharina Klepetko, Walter Olschewski, Horst Olschewski, Andrea
...
Published in
The Journal of pathology
In idiopathic pulmonary arterial hypertension (IPAH), global transcriptional changes induce a smooth muscle cell phenotype characterised by excessive proliferation, migration, and apoptosis resistance. Long non-coding RNAs (lncRNAs) are key regulators of cellular function. Using a compartment-specific transcriptional profiling approach, we sought t...
Sánchez-Duffhues, Gonzalo García de Vinuesa, Amaya van de Pol, Vera Geerts, Marlieke E de Vries, Margreet R Janson, Stef Gt van Dam, Hans Lindeman, Jan H Goumans, Marie-José Ten Dijke, Peter
...
Published in
The Journal of pathology
Endothelial-to-mesenchymal transition (EndMT) has been unveiled as a common cause for a multitude of human pathologies, including cancer and cardiovascular disease. Vascular calcification is a risk factor for ischemic vascular disorders and slowing calcification may reduce mortality in affected patients. The absence of early biomarkers hampers the ...
Westbrook, Jules A Wood, Steven L Cairns, David A McMahon, Kathryn Gahlaut, Renu Thygesen, Helene Shires, Mike Roberts, Stephanie Marshall, Helen Oliva, Maria R
...
Published in
The Journal of pathology
Skeletal metastasis occurs in around 75% of advanced breast cancers, with the disease incurable once cancer cells disseminate to bone, but there remains an unmet need for biomarkers to identify patients at high risk of bone recurrence. This study aimed to identify such a biomarker and to assess its utility in predicting response to adjuvant zoledro...
Podmirseg, Silvio R Vosper, Jonathan Hengst, Ludger
Published in
The Journal of Pathology
Lung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non‐small cell lung carcinoma (NSCLC) subtype accounting for the majority of cases. Therefore, an urgent need exists for a more detailed dissection of the molecular events driving NSCLC development and the identification of clinically relevant biomarkers. Ev...
Khalil, Ramzi Koop, Klaas Kreutz, Reinhold Spaink, Herman P Hogendoorn, Pancras Cw Bruijn, Jan A Baelde, Hans J
Published in
The Journal of pathology
Dynamin plays an essential role in maintaining the structure and function of the glomerular filtration barrier. Specifically, dynamin regulates the actin cytoskeleton and the turnover of nephrin in podocytes, and knocking down dynamin expression causes proteinuria. Moreover, promoting dynamin oligomerization with Bis-T-23 restores podocyte function...
