Bende, Richard J Slot, Linda M Kwakkenbos, Mark J Wormhoudt, Thera Am Jongejan, Aldo Verstappen, Gwenny M van Kampen, Antoine Cm Guikema, Jeroen Ej Kroese, Frans Gm van Noesel, Carel Jm
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Published in
The Journal of pathology
We recently demonstrated that normal memory B lymphocytes carry a substantial number of de novo mutations in the genome. Here, we performed exome-wide somatic mutation analyses of bona fide autoreactive rheumatoid factor (RF)-expressing memory B cells retrieved from patients with Sjӧgren's syndrome (SS). The amount and repertoire of the de novo exo...
Bussani, Rossana Zentilin, Lorena Correa, Ricardo Colliva, Andrea Silvestri, Furio Zacchigna, Serena Collesi, Chiara Giacca, Mauro
Published in
The Journal of pathology
SARS-CoV-2 infection is clinically heterogeneous, ranging from asymptomatic to deadly. A few patients with COVID-19 appear to recover from acute viral infection but nevertheless progress in their disease and eventually die, despite persistent negativity at molecular tests for SARS-CoV-2 RNA. Here, we performed post-mortem analyses in 27 consecutive...
Bekkhus, Tove Olofsson, Anna Sun, Ying Magnusson, Peetra U Ulvmar, Maria H
Published in
The Journal of pathology
Lymph node (LN) lipomatosis is a common but rarely discussed phenomenon associated with aging that involves a gradual exchange of the LN parenchyma into adipose tissue. The mechanisms behind these changes and the effects on the LN are unknown. We show that LN lipomatosis starts in the medullary regions of the human LN and link the initiation of lip...
De Noon, Solange Piggott, Robert Trotman, Jamie Tadross, John A Fittall, Matthew Hughes, Debbie Ye, Hongtao Munasinghe, Emani Murray, Matthew Tirabosco, Roberto
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Published in
The Journal of pathology
The FOS gene family has been implicated in tumourigenesis across several tumour types, particularly mesenchymal tumours. The rare fibrous tumour desmoplastic fibroblastoma is characterised by overexpression of FOSL1. However, previous studies using cytogenetic and molecular techniques did not identify an underlying somatic change involving the FOSL...
Tang, Wing Chung Tsao, Sai Wah Jones, Gareth E Liu, Xiong Tsai, Ming Han Delecluse, Henri-Jacques Dai, Wei You, Chanping Zhang, Jun Huang, Shaina Chor Mei
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Published in
The Journal of pathology
Invadopodia are actin-rich membrane protrusions that digest the matrix barrier during cancer metastasis. Since the discovery of invadopodia, they have been visualized as localized and dot-like structures in different types of cancer cells on top of a 2D matrix. In this investigation of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (N...
Sundararajan, Vignesh Tan, Tuan Zea Lim, Diana Peng, Yanfen Wengner, Antje Margret Ngoi, Natalie Yan Li Jeyasekharan, Anand D Tan, David Shao Peng
Published in
The Journal of pathology
Excessive genomic instability coupled with abnormalities in DNA repair pathways induces high levels of 'replication stress' when cancer cells propagate. Rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention towards targeting cell cycle checkpoint kinases (such as ATR, CHK1, WEE1, and others) along t...
Pettitt, Geoffrey A Hurst, Carolyn D Khan, Zubeda McPherson, Helen R Dunning, Matthew C Alder, Olivia Platt, Fiona M Black, Emma Vi Burns, Julie E Knowles, Margaret A
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Published in
The Journal of pathology
Alterations of fibroblast growth factor receptors (FGFRs) are common in bladder and other cancers and result in disrupted signalling via several pathways. Therapeutics that target FGFRs have now entered the clinic, but, in common with many cancer therapies, resistance develops in most cases. To model this, we derived resistant sublines of two FGFR-...
Eymael, Jennifer van den Broek, Martijn Miesen, Laura Monge, Valerie Villacorta van den Berge, Bartholomeus T Mooren, Fieke Velez, Vicky Luna Dijkstra, Jelmer Hermsen, Meyke Bándi, Péter
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Published in
The Journal of pathology
Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three-dimensional human tissue analysis revealed that STCs are preferentially located within inner bends of the tubule and are barely present in you...
Fernández‐Cortés, Mónica Delgado‐Bellido, Daniel Bermúdez‐Jiménez, Eloísa Paramio, Jesús M O'Valle, Francisco Vinckier, Stefan Carmeliet, Peter Garcia‐Diaz, Angel Oliver, F Javier
Published in
The Journal of Pathology
Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop pseudovascular structures without the participation of endothelial cells. PARP1 is implicated in the activation of hypoxia‐inducible factors, which are crucial in tumor neovascularization. We have explored the role of hypoxia and PARP inhibition in VM. In uv...
Yang, Qin Miao, Qing Chen, Hui Li, Duo Luo, Yongfeng Chiu, Joanne Wang, Hong‐Jun Chuvanjyan, Michael Parmacek, Michael S Shi, Wei
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Published in
The Journal of Pathology
Abnormal growth of airway smooth muscle cells is one of the key features in asthmatic airway remodeling, which is associated with asthma severity. The mechanisms underlying inappropriate airway smooth muscle cell growth in asthma remain largely unknown. Myocd has been reported to act as a key transcriptional coactivator in promoting airway‐specific...
