Published in
The Journal of Heart and Lung Transplantation
Objectives The study was conducted to determine the long-term outcome of patients who underwent heart transplantation 15 to 20 years ago, in the cyclosporine era, and identify risk factors for death. Methods A retrospective analysis was done of 148 patients who had undergone heart transplantation between 1985 and 1991 at a single center. Operative ...
Published in
The Journal of Heart and Lung Transplantation
Although most late complications after lung transplantation are related to chronic rejection, airway anastomotic disease cannot be overlooked as a substantial contributor to morbidity and mortality. A rare, but nearly universally fatal example of anastomotic disease is fistula formation with the vascular system. Reports of fistula formation between...
Published in
The Journal of Heart and Lung Transplantation
Background In this investigation we studied the efficacy and durability of recombinant adeno-associated virus serotype 9 (rAAV9) vector–mediated gene transfer to the transplanted rat heart. Methods A rAAV9-CMV-lacZ vector diluted in cold (4°C) University of Wisconsin solution was used to perfuse the rat coronary vasculature for 20 minutes prior to ...
Published in
The Journal of Heart and Lung Transplantation
Advances in lung transplantation have improved 1-year survival rates, but allograft dysfunction continues to be a significant cause of post-transplant death. Diffuse alveolar damage is an early indication of allograft dysfunction and has been linked to gastroesophageal reflux. We report a case of diffuse alveolar damage–associated allograft dysfunc...
Published in
The Journal of Heart and Lung Transplantation
Background Body habitus assessment (BHA), be it wasted or obese, is a useful marker of nutritional status and overall medical condition. Wasting and obesity pre–heart transplant adversely affects outcomes in adults. The utility of BHA as a prognostic factor in children post-transplant is unknown. Methods Weight and height at listing and standard gr...
Published in
The Journal of Heart and Lung Transplantation
Background Cardiac allograft vasculopathy (CAV) in patients who have undergone heart transplantation leads to graft dysfunction and is still the major concern for long-term survival. Evaluation of coronary flow velocity reserve (CFR) has been established for diagnosis of CAV. Systemic application of adenosine vs intracoronary testing for CFR has be...
Published in
The Journal of Heart and Lung Transplantation
Background Pediatric heart transplant recipients with a positive complement-dependent cytotoxic (CDC) donor–recipient crossmatch are at high risk for rejection. We sought to correlate the pattern of C3d and C4d myocardial capillary deposition and pericapillary macrophage infiltration, possible markers of antibody-mediated rejection, to clinical evi...
Published in
The Journal of Heart and Lung Transplantation
Background This retrospective single-center study compared lymphocyte depletion in 144 heart transplant recipients using 2 different induction protocols with Thymoglobulin (Genzyme Transplant, Cambridge, MA). Methods Thymoglobulin (1.5 mg/kg) was given to 105 patients for 7 days (Thymo7) and 39 patients for 5 days (Thymo5). Results Patient clinical...
Published in
The Journal of Heart and Lung Transplantation
Background Guidelines for the diagnosis and grading of lymphocytic bronchiolitis (LB) have been available for more than a decade, but agreement is lacking concerning the clinical implications of this histologic finding. Objectives Study goals were to describe the overall prevalence and incidence of LB in a consecutive cohort of lung transplant reci...
Published in
The Journal of Heart and Lung Transplantation
Among solid organs, transfer of peanut allergy from donor to recipient has been implicated after liver transplantation. We report the first case in which such transfer occurred after a lung transplant. A 42-year-old woman with history of sarcoidosis underwent a successful bilateral lung transplant from a donor who died from anaphylactic shock after...
