Published in The Journal of Heart and Lung Transplantation
Background Infections are common after lung transplantation. This report analyzes infections and associated pathogens identified in 202 lung transplant recipients. Methods Infections were tallied according to sites of infection and associated pathogen(s). Infection events were also categorized by post-operative Days 0 to 100, 101 to 365, and after ...
Published in The Journal of Heart and Lung Transplantation
Background Pediatric heart transplant recipients with a positive complement-dependent cytotoxic (CDC) donor–recipient crossmatch are at high risk for rejection. We sought to correlate the pattern of C3d and C4d myocardial capillary deposition and pericapillary macrophage infiltration, possible markers of antibody-mediated rejection, to clinical evi...
Published in The Journal of Heart and Lung Transplantation
Background The Eurotransplant community adopted an urgency-based heart allocation algorithm in August 2000. The effect of the new allocation policy on critically ill patients with end-stage heart failure was studied. Methods During 1997–1999 (old algorithm) and 2001–2006 (new algorithm), 661 heart transplant candidates received heart transplantatio...
Published in The Journal of Heart and Lung Transplantation
Background This retrospective single-center study compared lymphocyte depletion in 144 heart transplant recipients using 2 different induction protocols with Thymoglobulin (Genzyme Transplant, Cambridge, MA). Methods Thymoglobulin (1.5 mg/kg) was given to 105 patients for 7 days (Thymo7) and 39 patients for 5 days (Thymo5). Results Patient clinical...
Published in The Journal of Heart and Lung Transplantation
Background Guidelines for the diagnosis and grading of lymphocytic bronchiolitis (LB) have been available for more than a decade, but agreement is lacking concerning the clinical implications of this histologic finding. Objectives Study goals were to describe the overall prevalence and incidence of LB in a consecutive cohort of lung transplant reci...
Published in The Journal of Heart and Lung Transplantation
Lung transplant recipients are at increased risk for Mycobacterium tuberculosis infection secondary to the intense immunosuppressive regimen after transplantation. We report a case of fatal M tuberculosis infection that presented as a pericardial abscess in a lung transplant recipient and review the literature.
Published in The Journal of Heart and Lung Transplantation
Although most late complications after lung transplantation are related to chronic rejection, airway anastomotic disease cannot be overlooked as a substantial contributor to morbidity and mortality. A rare, but nearly universally fatal example of anastomotic disease is fistula formation with the vascular system. Reports of fistula formation between...
Published in The Journal of Heart and Lung Transplantation
Objectives The study was conducted to determine the long-term outcome of patients who underwent heart transplantation 15 to 20 years ago, in the cyclosporine era, and identify risk factors for death. Methods A retrospective analysis was done of 148 patients who had undergone heart transplantation between 1985 and 1991 at a single center. Operative ...
Published in The Journal of Heart and Lung Transplantation
Background Sleep-disordered breathing (SDB) is common in patients with severe chronic respiratory failure, but there are no data describing the prevalence of SDB among patients listed for lung transplantation or the effect of transplantation on SDB. We sought to determine the prevalence and impact of SDB before and after lung transplantation. Metho...
Published in The Journal of Heart and Lung Transplantation
Background Pediatric heart transplantation has now been successfully performed for more than 20 years. As survival rates have improved, more attention is now focused on long-term outcomes. Methods This report reviews the literature on developmental outcomes after pediatric heart transplantation. Results Pediatric patients undergoing heart transplan...
