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Acute promyelocytic leukemia: New issues on pathogenesis and treatment response

Published in The International Journal of Biochemistry & Cell Biology in Jan 01, 2007

Abstract Pathogenesis of acute promyelocytic leukemia appears to be one of the best understood among human malignancies. The ability of retinoic acid (RA) and arsenic trioxide to directly target the oncogenic promyelocytic leukemia-retinoic receptor A (PML-RARA) fusion protein also made this disease the first model for oncogene-targeted therapies. ...

ATP synthase oligomerization: From the enzyme models to the mitochondrial morphology

Published in The International Journal of Biochemistry & Cell Biology

Abstract Mitochondrial F1Fo ATP synthase is an enzymatic complex involved in the aerobic synthesis of ATP. It is well known that several enzymes are organized in supramolecular complexes in the inner mitochondrial membrane. The ATP synthase supramolecular assembly is mediated through two interfaces. One leads to dimer formation and the other to oli...

The WAP protein Trappin-2/Elafin: a handyman in the regulation of inflammatory and immune responses.

Published in The International Journal of Biochemistry & Cell Biology

Chromatin mechanisms in the developmental control of imprinted gene expression

Published in The International Journal of Biochemistry & Cell Biology