Published in The European journal of neuroscience
Area V2 of the cerebral cortex of higher primates has a complex cytochrome oxidase architecture whose most characteristic element is a set of stripes running orthogonal to its long axis. These stripes can be related to the segregation between the various pathways in which V2 participates. In the macaque monkey the more metabolically active stripes ...
Published in The European journal of neuroscience
N-methyl-D-aspartate (NMDA; 40 microM) induced depolarizations of cortical wedges that were reduced by 30 - 60% in the presence of D-2-amino-5-phosphonovalerate (D-AP5; 5 microM), ketamine (5 microM), dextrorphan (5 microM), magnesium (500 microM), kynurenate (200 microM), and 1-hydroxy-3-aminopyrrolidone-2 (HA-966; 200 microM). Superfusion with gl...
Published in The European journal of neuroscience
We have studied the connections between two visual areas of macaque monkey cortex, V2 and V4, by injecting wheat-germ agglutinin horseradish peroxidase (HRP-WGA) into V4 and examining the distribution of labelled cells and terminals in V2, in relation to its characteristically striped cytochrome oxidase architecture. The cells projecting from V2 to...
Published in The European journal of neuroscience
Area V5 or MT of primate extrastriate visual cortex is specialized for involvement in the analysis of motion and receives input from two layers, 4B and 6, of the striate cortex or V1. Injections of horseradish peroxidase - wheatgerm agglutinin into V5 reveal a patchy distribution of labelled cells and axonal terminals in layer 4B, suggesting the pr...
Published in The European journal of neuroscience
Wallerian degeneration of the distal stump of a severed peripheral nerve involves invasion by myelomonocytic cells, whose presence is necessary for destruction of myelin and for initiating mitosis in Schwann cells (Beuche and Friede, 1984). Degeneration of the distal ends of the axons themselves is assumed to occur by autolytic mechanisms. We descr...
Published in The European journal of neuroscience
In the central nervous system of fish and frogs, some, but not all, axons can regenerate. Retinal ganglion cells are among those that can. The retinae of fish and frogs produce new retinal neurons, including ganglion cells, for months or years after hatching. We have evaluated the hypothesis that retinal axonal regeneration is obligatorily linked t...
Published in The European journal of neuroscience
The synaptic responses of lumbar ventral horn neurons including identified flexor motoneurons, to graded stimulation of peripheral nerves have been recorded in vitro in the young rat spinal cord-hindlimb preparation. Single shock stimulation of low threshold myelinated afferents evoked short latency ( 1 s) in all cells. In the majority of cells (67...
Published in The European journal of neuroscience
Calcium channel currents have been recorded from cultured rat sensory neurons at clamp potentials of between -30 and +120 mV. At large depolarizing potentials between +50 and +120 mV, the current was outward. This outward current was shown to be largely due to ions passing through calcium channels, because it was substantially although generally in...
Published in The European journal of neuroscience
We have used computer simulations as one way to test the hypothesis that locomotor rhythm production for swimming in frog embryo spinal cord depends on rebound from inhibition and is sustained by mutual re-excitation among spinal excitatory interneurons. All simulations were based on physiological and anatomical data on the neurons and circuitry of...
Published in The European journal of neuroscience
The two monoclonal antibodies, bd-17 and bd-24, are specific for beta- and alpha-subunits of the GABAA/benzodiazepine receptor/chloride channel complex respectively. An abundance of both subunits has been revealed in the visual thalamus of the cat by light microscopic immunocytochemistry using these antibodies. The alpha-subunit specific antibody a...
