Ganguly, Devargya Thomas, Joshua Abby Ali, Abid Kumar, Rahul
Published in
The European journal of neuroscience
Erythropoietin-producing hepatoma (Eph) receptors belong to a family of tyrosine kinase receptors that plays a pivotal role in the development of the brain. Eph can be divided broadly into two groups, namely, EphA and EphB, comprising nine and five members, respectively. In recent years, the role of EphA-4 has become increasingly apparent in the on...
Anwar, Mai M Özkan, Esra Gürsoy-Özdemir, Yasemin
Published in
The European journal of neuroscience
The brain is a highly vascularized tissue protected by the blood-brain barrier (BBB), a complex structure allowing only necessary substances to pass through into the brain while limiting the entrance of harmful toxins. The BBB comprises several components, and the most prominent features are tight junctions between endothelial cells (ECs), which ar...
Samson, Alexandria D Shen, Kelly Grady, Cheryl L McIntosh, Anthony R
Published in
The European journal of neuroscience
Mild cognitive impairment (MCI) is a prevalent and complex condition among older adults that often progresses into Alzheimer's disease (AD). Although MCI affects individuals differently, there are specific indicators of risk commonly associated with the development of MCI. The present study explored the prevalence of seven established MCI risk cate...
Avancini, Chiara Jennings, Sally Chennu, Srivas Noreika, Valdas Le, April Bekinschtein, Tristan A Walpert, Madeleine J Clare, Isabel C H Holland, Anthony J Zaman, Shahid H
...
Published in
The European journal of neuroscience
Down's syndrome is associated with pathological ageing and a propensity for early-onset Alzheimer's disease. The early symptoms of dementia in people with Down's syndrome may reflect frontal lobe vulnerability to amyloid deposition. Auditory predictive processes rely on the bilateral auditory cortices with the recruitment of frontal cortices and ap...
Cheron, Guy Ristori, Dominique Marquez-Ruiz, Javier Cebolla, Anna-Maria Ris, Laurence
Published in
The European journal of neuroscience
Alzheimer's disease is histopathologically well defined by the presence of amyloid deposits and tau-related neurofibrillary tangles in crucial regions of the brain. Interest is growing in revealing and determining possible pathological markers also in the cerebellum as its involvement in cognitive functions is now well supported. Despite the centra...
Celik Topkara, Kubra Kilinc, Erkan Cetinkaya, Ayhan Saylan, Aslıhan Demir, Serif
Published in
The European journal of neuroscience
Due to the complex nature of Alzheimer's disease (AD), it is important to investigate agents with multiple effects in the treatment of AD. Carvacrol possesses anti-acetylcholinesterase, anti-oxidant, and neuroprotective properties. We therefore investigated therapeutic effects of carvacrol on cell viability, oxidative stress, and cognitive impairme...
Gregory, Sarah Blennow, Kaj Homer, Natalie Z M Ritchie, Craig W Muniz-Terrera, Graciela
Published in
The European journal of neuroscience
Type 2 diabetes is a robust predictor of cognitive impairment. Impairment in allocentric processing may help identify those at increased risk for Alzheimer's disease dementia. The objective of this study was to investigate the performance of participants with and without diabetes on a task of allocentric spatial processing. This was a cross-section...
Bera, Arpita Lavanya, Gantyada Reshmi, Ravada Dev, Kapil Kumar, Rahul
Published in
The European journal of neuroscience
Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged as the most common form of dementia in the elderly. Two major pathological hallmarks have been identified for AD: extracellular amyloid plaques and intracellular neurofibrillary tangles (NFT). Recently, dynamin-related protein 1 (Drp1) was recognized to contribute signi...
Peralta Ramos, Javier María Kviatcovsky, Denise Schwartz, Michal
Published in
The European journal of neuroscience
The incidence of age-related dementia is growing with increased longevity, yet there are currently no disease-modifying therapies for these devastating disorders. Studies over the last several years have led to an evolving awareness of the role of the immune system in supporting brain maintenance and repair, displaying a diverse repertoire of funct...
Saunders, Tyler S Gadd, Danni A Spires-Jones, Tara L King, Declan Ritchie, Craig Muniz-Terrera, Graciela
Published in
The European journal of neuroscience
A biomarker associated with cognition in neurodegenerative dementias would aid in the early detection of disease progression, complement clinical staging and act as a surrogate endpoint in clinical trials. The current systematic review evaluates the association between cerebrospinal fluid protein markers of synapse loss and neuronal injury and cogn...
