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Retraction: Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.

Published in The EMBO journal

Phosphatidylinositol 4,5‐bisphosphate controls Rab7 and PLEKHM 1 membrane cycling during autophagosome–lysosome fusion

Published in The EMBO Journal

Retraction: "CITRX thioredoxin interacts with the tomato Cf-9 resistance protein and negatively regulates defence".

Published in The EMBO journal

Function and dysfunction of the PI system in membrane trafficking.

Published in The EMBO journal

The phosphoinositides (PIs) function as efficient and finely tuned switches that control the assembly-disassembly cycles of complex molecular machineries with key roles in membrane trafficking. This important role of the PIs is mainly due to their versatile nature, which is in turn determined by their fast metabolic interconversions. PIs can be tig...

Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signaling

Published in The EMBO Journal

STIM1 (c)AMPs up melanogenesis.

Published in The EMBO journal

No way out: when RNA elements promote nuclear retention

Published in The EMBO Journal

The proper localization of RNA transcripts is a highly controlled and fine‐tuned process. Indeed, regulation of RNA trafficking is mediated by both cis ‐acting elements and trans ‐acting factors, and defects in either mechanism have been associated with disease. Identifying the RNA sequence motifs that determine cellular localization for a given tr...

Shuttle mission in the mitochondrial intermembrane space.

Published in The EMBO journal

Sorting out “non‐canonical” autophagy

Published in The EMBO Journal

Canonically, LC 3 lipidation has been associated with autophagy pathways but it becomes increasingly clear that this modification can also occur during autophagy‐unrelated processes. In this issue, Florey and colleagues find that the WD 40 domain of ATG 16L1 is dispensable for LC 3 lipidation during starvation‐induced autophagy but required for its...

Structure of the human myostatin precursor and determinants of growth factor latency.

Published in The EMBO journal

Myostatin, a key regulator of muscle mass in vertebrates, is biosynthesised as a latent precursor in muscle and is activated by sequential proteolysis of the pro-domain. To investigate the molecular mechanism by which pro-myostatin remains latent, we have determined the structure of unprocessed pro-myostatin and analysed the properties of the prote...