Elewski, B Brand, S Degenhardt, T Curelop, S Pollak, R Schotzinger, R Tavakkol, A
Published in
The British journal of dermatology
Onychomycosis is a fungal disease that affects the fingernails and toenails and is predominantly caused by dermatophytes. VT-1161 is a novel inhibitor of fungal CYP51 through the inhibition of lanosterol demethylase, and has demonstrated potent activity against Trichophyton rubrum and Trichophyton mentagrophytes. To evaluate the safety and efficacy...
Lotz, M Budden, T Furney, S J Virós, A
Published in
The British journal of dermatology
Many cancer types display sex and age disparity in incidence and outcome. The mutational load of tumours, including melanoma, varies according to sex and age. However, there are no tools to explore systematically whether clinical variables such as age and sex determine the genomic landscape of cancer. To establish a mathematical approach using mela...
Lin, Z Niu, Y Jiang, Y Chen, B Peng, L Mi, T Huang, N Li, W Xu, D Chen, R
...
Published in
The British journal of dermatology
Exposure to fine particulate matter (with an aerodynamic diameter ≤ 2·5 μm, PM2·5 ) air pollution has been associated with skin-related diseases or disorders. To evaluate the potential skin-protective effects of fish-oil supplementation against PM2·5 exposure. This is an exploratory analysis based on a pilot randomized, double-blind, placebo-contro...
Bhat, T S Herbosa, C M Rosenberg, A R Sogade, O Jeffe, D B Mehta-Shah, N Semenov, Y R Musiek, A C
Published in
The British journal of dermatology
Cutaneous T-cell lymphoma (CTCL) negatively impacts quality of life (QoL), but existing QoL questionnaires may not comprehensively reflect patients' experience. To identify the aspects of QoL that are most meaningful to patients with CTCL and to evaluate existing QoL instruments in this context. Semistructured interviews were conducted between May ...
Portelli, F Galli, F Cattaneo, L Cossa, M De Giorgi, V Forte, G Fraternali Orcioni, G Gianatti, A Indini, A Labianca, A
...
Published in
The British journal of dermatology
The presence of ulceration has been recognized as an adverse prognostic factor in primary cutaneous melanoma (PCM). To investigate whether the extent of ulceration (EoU) predicts relapse-free survival (RFS) and overall survival (OS) in PCM. We retrieved data for 477 patients with ulcerated PCM from databases of the Italian Melanoma Intergroup. Univ...
Loney, T Paulo, M S Modenese, A Gobba, F Tenkate, T Whiteman, D C Green, A C John, S M
Published in
The British journal of dermatology
Individual studies have suggested that the association between occupational exposure to solar ultraviolet radiation (UVR) and the development of keratinocyte cancers (KCs) may only be valid in populations of European ancestry living in certain geographical regions. Comparative global data are scarce and so this review aimed to summarize current evi...
Murdoch, M E
Published in
The British journal of dermatology
Onchocerciasis is a neglected tropical disease caused by a nematode parasite, Onchocerca volvulus, and transmitted by bites of Simulium blackflies which breed near fast-flowing rivers. In humans, thousands of microfilariae (immature worms) migrate to the skin and eyes where they cause pathology. Historically, much research was devoted to the seriou...
Iskandar, I Y K Parisi, R Griffiths, C E M Ashcroft, D M
Published in
The British journal of dermatology
There is a lack of any overview of changes over time and variation in the epidemiology of psoriasis with age and between genders. To perform a systematic review of published population-based studies on variations in psoriasis incidence and prevalence with age and between genders, and to explore trends in psoriasis epidemiology over time. Eleven ele...
Cox, V Fuller, L C Engelman, D Steer, A Hay, R J
Published in
The British journal of dermatology
Scabies is one of the most common disorders identified in any estimate of global skin disease prevalence. Furthermore, quantifying its impact on individuals and societies has been problematic. There has been a lack of clear case definitions and laboratory tests. There have been few epidemiological studies, particularly those focusing on low-income ...
Ribero, S Zugna, D Spector, T Bataille, V
Published in
The British journal of dermatology
Naevi number changes with age. Thus, a better understanding of naevus biology will shed more light on the genetic and environmental factors involved in melanoma development. To use a two-wave study to better understand the evolution of naevi in healthy adults. This study is a prospective two-wave study based on adult twins from the TwinsUK registry...
