Sen, H Nida Vannella, Kevin M Wang, Yujuan Chung, Joon-Yong Kodati, Shilpa Ramelli, Sabrina C Lee, Jung Wha Perez, Paola Stein, Sydney R Grazioli, Alison
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Published in
The American journal of pathology
Ophthalmic manifestations and tissue tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported in association with coronavirus disease 2019 (COVID-19), but the pathology and cellular localization of SARS-CoV-2 are not well characterized. The objective of this study was to evaluate macroscopic and microscopic changes...
Lee, Yu Jin Seok, Sang Hyeok Lee, Na Yun Choi, Hee Jin Lee, Yoon Woo Chang, Hee Jung Hwang, Ji-Yeon On, Da In Noh, Hyun Ah Lee, Su-Bin
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Published in
The American journal of pathology
The disease severity of coronavirus disease 2019 (COVID-19) varies considerably from asymptomatic to serious, with fatal complications associated with dysregulation of innate and adaptive immunity. Lymphoid depletion in lymphoid tissues and lymphocytopenia have both been associated with poor disease outcomes in patients with COVID-19, but the mecha...
Wu, Kangyun Zhang, Yong Austin, Stephen R Yin-Declue, Huiqing Byers, Derek E Crouch, Erika C Holtzman, Michael J
Published in
The American journal of pathology
Respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can trigger chronic lung disease that persists and even progresses after expected clearance of infectious virus. To gain an understanding of this process, the current study examined a series of consecutive fatal cases of coronavirus disease 2019 (COVID-19) ...
Gayden, Jenesis Hu, Shikai Joseph, Paul N Delgado, Evan Liu, Silvia Bell, Aaron Puig, Stephanie Monga, Satdarshan P Freyberg, Zachary
Published in
The American journal of pathology
Hepatic zonation is critical for most metabolic functions in liver. Wnt signaling plays an important role in establishing and maintaining liver zonation. Yet, the anatomic expression of Wnt signaling components, especially all 10 Frizzled (Fzd) receptors, has not been characterized in adult liver. To address this, the spatial expression of Fzd rece...
Nuber, Silke Selkoe, Dennis J
Published in
The American journal of pathology
Abnormal aggregation of α-synuclein (αS) is thought to initiate neuronal dysfunction and death in Parkinson disease (PD). In addition to higher-molecular-weight, oligomeric, and polymeric forms of αS associated with neurotoxicity and disease, recent findings indicate the occurrence of physiological tetrameric assemblies in healthy neurons in cultur...
Roy, Adhiraj Prasad, Sahdeo Chen, Yuzhou Chao, Yapeng Liu, Yu Zhao, Jinjun Wang, Qiming Jane
Published in
The American Journal of Pathology
Advanced-stage prostate tumors metastasize to the bone, often causing death. The protein kinase D (PKD) family has been implicated in prostate cancer development; however, its role in prostate cancer metastasis remains elusive. This study examined the contribution of PKD, particularly PKD2 and PKD3 (PKD2/3), to the metastatic potential of prostate ...
Corbett, Cali B St Paul, Amanda Leigh, Tani Kelemen, Sheri E Peluzzo, Amanda M Okune, Rachael N Eguchi, Satoru Haines, Dale S Autieri, Michael V
Published in
The American journal of pathology
Vascular smooth muscle cells (VSMC) play a critical role in the development and pathogenesis of intimal hyperplasia indicative of restenosis and other vascular diseases. Fragile-X related protein-1 (FXR1) is a muscle-enhanced RNA binding protein whose expression is increased in injured arteries. Previous studies suggest that FXR1 negatively regulat...
Walhart, Tara A Vacca, Bryanna Hepperla, Austin J Hamad, Samera H Petrongelli, James Wang, Yemin McKean, Erin L Moksa, Michelle Cao, Qi Yip, Stephen
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Published in
The American journal of pathology
Poorly differentiated (PD) chordoma, a rare, aggressive tumor originating from notochordal tissue, shows loss of SMARCB1 expression, a core component of the Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes. To determine the impact of SMARCB1 re-expression on cell growth and gene expression, two SMARCB1-negative PD chordoma ce...
Rong, Ruichen Wang, Shidan Zhang, Xinyi Wen, Zhuoyu Cheng, Xian Jia, Liwei Yang, Donghan M Xie, Yang Zhan, Xiaowei Xiao, Guanghua
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Published in
The American journal of pathology
Whole slide imaging is becoming a routine procedure in clinical diagnosis. Advanced image analysis techniques have been developed to assist pathologists in disease diagnosis, staging, subtype classification, and risk stratification. Recently, deep learning algorithms have achieved state-of-the-art performances in various imaging analysis tasks, inc...
Yuan, Xinxu Bhat, Owais M Zou, Yao Zhang, Yang Li, Pin-Lan
Published in
The American journal of pathology
To study the mechanism by which nonalcoholic fatty liver disease (NAFLD) contributes to vascular endothelial Nod-like receptor pyrin domain 3 (NLRP3) inflammasome activation and neointima hyperplasia, NAFLD was established in high-fat diet (HFD)-treated Asah1fl/fl/Albcre (liver-specific deletion of the acid ceramidase gene Asah1) mice. Compared wit...
