Roussin, Anne Doazan-d'Ouince, Odile Géniaux, Hélène Halberer, Clémence
Published in
Thérapie
The objective of this paper is to present an evaluation of the potential for abuse of and dependence on a drug from the data obtained from the different pharmacoepidemiological tools used by the French network for evaluation and information on pharmacodependence and addiction monitoring taking the example of tramadol. Comparison of the data from sp...
Boucherie, Quentin Frauger, Elisabeth Thirion, Xavier Mallaret, Michel Micallef, Joëlle
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Thérapie
The study has shown the rapid spread of the capsule formulation among methadone users. This may suggest that the capsule is well accepted by patients and the medical community. However, the monitoring of methadone-related deaths should continue because of the pharmacodynamic properties of methadone and the context of relaxed regulations concerning ...
Micallef, Joëlle Frauger, Elisabeth Palmaro, Aurore Boucherie, Quentin Mestre, Maryse Lapeyre
Published in
Therapie
Naudet, Florian Boussageon, Rémy Palpacuer, Clément Gallet, Laurent Reymann, Jean-Michel Falissard, Bruno
Published in
Thérapie
There is a long-standing polemic concerning the usefulness of antidepressants in the treatment of major depressive disorder. In this paper, we propose to highlight some aspects of this controversy by exploring the mutual influence of psychopharmacology and trial methodologies. Indeed, antidepressant efficacy, if not proved, was accepted before anti...
Bilbault, Pascal Beslay, Nathalie Carton, Laurence Duffet, Jean-Pierre Gueniche, Audrey Lang, Marie Menuet, Dominique Prunier, Hélène Levy, Michel
Published in
Therapie
The active patient participation in clinical trials is key for a competitive clinical research. Given this, the Health Industry Physicians and Actors Association (AMIPS) has set up a working group to make communication recommendations towards patients. The group was made of patients, investigators and industry sponsors representatives. Efficacious ...
Saint-Paul, Laure Peyro Martin, Jocelyne Gaillard, Cathy Garnier, Aline Mosquet, Brigitte Guillamo, Jean-Sébastien Parienti, Jean-Jacques
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Therapie
The modalities for anti-dementia drugs' discontinuation are not consensual. The objectives of the study were the followings, describe: i) the reasons for discontinuation of anti-dementia drugs of patients treated in a residency for dependent elderly people, ii) security of sudden discontinuation, iii) evolution of troubles. Our longitudinal descrip...
Linselle, Mélanie Montastruc, François Jantzen, Hélène Valnet-Rabier, Marie-Blanche Haramburu, Françoise Coquerel, Antoine Gouraud, Aurore Perault-Pochat, Marie-Christine Bagheri, Haleh Montastruc, Jean-Louis
...
Published in
Thérapie
The present work reviews the case reports of drug-induced sleep apnea recorded in the French pharmacovigilance database. Notifications are very rare (around 1/100 000 notifications). This paper shows that sleep apnea can be aggravated or revealed by some drugs. Main drugs involved were psychotropics (benzodiazepines, neuroleptics) and opioids.
Mohammad, Sohail Arshad, Usman Abbass, Nasir Parvez, Irfan Abbas, Ghulam Mahmood, Wajahat
Published in
Thérapie
A two way, randomized cross-over bioequivalence study was conducted to analyse the rate and extent of absorption of atorvastatin after a single dose of 80 mg atorvastatin as atorvastatin calcium tablets. The study was carried out using healthy male volunteers (N = 24). A high performance liquid chromatography method was employed to determine the le...
Micallef, Joëlle
Published in
Thérapie
Tillement, Jean-Paul Hauw, Jean-Jacques Papadopoulos, Vassilios Montastruc, Jean-Louis
Published in
Thérapie