Published in Therapie
Advances in lung transplantation allow the women of childbearing age to consider becoming mothers. When planning to become pregnant, a therapeutic drug management of immunosuppressive drugs and associated therapies is required. It must take into account teratogenic and fetotoxic drugs, as well as pharmacokinetic changes encountered during pregnancy...
Published in Therapie
DOA are less prescribed than VKA in patients treated with APA. DOA switch to VKA was not systematic in patients diagnosed for a long time. However, international normalized ratio (INR) values were stable in most of patients treated with VKA at the switching to DOA. A more powerful study would confirm the factors associated with DOA prescription.
Published in Therapie
Many drugs can affect cognitive function in the elderly. Anticholinergic and psychotropic drugs can cause or exacerbate cognitive impairment and can increase the occurrence of dementia in the elderly. In healthy elderly adults, antihypertensive drugs could improve cognition and reduce the dementia risk. By contrast, randomized clinical trials evalu...
Published in Therapie
We describe a case of tinnitus occurred during a bleomycin monotherapy for Kaposi's sarcoma.
Published in Thérapie
This study confirms the interest of Qutenza® for heavily pretreated, refractory patients with PNP. The clinical profile of responders has to be further investigated in large observational studies.
Published in Therapie
To describe the serious adverse drug reactions (ADR) in elderly subjects aged over 65 years and assess their preventability. A retrospective study was conducted at the Regional Pharmacovigilance Center of Champagne-Ardenne (northeast of France) between January and May 2013. Patients aged over 65 years who presented a serious ADR notified to the Reg...
Published in Thérapie
Le résumé des caractéristiques d’un produit (le RCP), principale annexe de son dossier d’autorisation de mise sur le marché, comporte 12 rubriques. Les rubriques 1 à 3 concernent la dénomination, le dosage, la forme pharmaceutique et la composition du médicament. La rubrique 4 est celle des données cliniques (indications, posologies, modes d’admini...
Published in Thérapie
Objective. To evaluate the overall cancer risk, primarily breast cancer, for women exposed to diethylstilbestrol (DES) in utero in France. Methods. A cohort of 3 436 prenatally DES exposed women and a comparable cohort of 3 256 unexposed women were recruited retrospectively from voluntary responses to questionnaires, and cases were ascertained by m...
Published in Thérapie
Introduction. L’acide valproïque (VPA) est un antiépileptique à large spectre. Face à sa variabilité pharmacocinétique et à l’influence de facteurs intrinsèques et extrinsèques tels que l’observance thérapeutique, le suivi thérapeutique pharmacologique (STP) du VPA est indiqué chez l’enfant. Le but de ce travail est d’identifier l’effet de l’observ...
Published in Thérapie
Depression is a complex disorder with heterogeneous clinical anomalies whose neurobiological understanding still remains unclear. Medications have been implicated as potential causes of depression but for many of them, data are controversial. The present study aims to investigate association bet ween drugs and reports of depression. We used the cas...
