Miura, Kosei Kurosaki, Hiromasa Utsumi, Nobuko Sakurai, Hideyuki
Published in
Technology in Cancer Research & Treatment
Purpose: The aim of this study is to comparatively examine the possibility of reducing the exposure dose to organs at risk, such as the hippocampus and lens, and improving the dose distribution of the planned target volume with and without the use of a head-tilting base plate in hippocampal-sparing whole-brain radiotherapy using tomotherapy. Method...
Liao, Bo Chen, Shuangquan Li, Yugen Yang, Zhaohui Yang, Ying Deng, Xianzhong Ke, Sha
Published in
Technology in Cancer Research & Treatment
Background: Long non-coding RNA bladder cancer associated transcript 1 (BLACAT1) is oncogenic in several types of cancers. However, little is known concerning its expression and function in prostate cancer. Methods: Paired prostate cancer samples were collected, and the expression levels of BLACAT1, miR-29a-3p and disheveled segment polarity protei...
Liu, Wenlin Zhan, Jiandong Zhong, Rong Li, Rui Sheng, Xiaoli Xu, Mimi Lu, Zhongming Zhang, Siyi
Published in
Technology in Cancer Research & Treatment
Background: Laryngeal cancer is one of the most common malignant tumors among head and neck cancers. Accumulating studies have indicated that long noncoding RNAs (lncRNAs) play an important role in laryngeal cancer occurrence and progression, however, the functional roles and relative regulatory mechanisms of lncRNA growth arrest-specific transcrip...
Zhou, Shichao Wang, Lili Zhang, Wenying Liu, Feng Zhang, Yanjie Jiang, Bin Wang, JiongYi Yuan, Haihua
Published in
Technology in Cancer Research & Treatment
Background: To investigate the relationship of circulating tumor cells (CTCs) and the clinical characteristic parameters and prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Methods: The retrospective clinical study included 95 patients with HNSCC who after surgery in Shanghai Ninth People’s Hospital affiliated to Shanghai ...
Xu, Hongyan Mao, Minghuan Zhao, Rui Zhao, Qing
Published in
Technology in Cancer Research & Treatment
Background: Prostate cancer is the most commonly diagnosed cancer and second leading cause of cancer death in men. Enoxacin, a third-generation fluoroquinolone antibiotic, was found with anti-proliferative effects against many cancer types. This study was to further investigate its effects against prostate cancer and explore the underlying molecula...
Zhan, Shanqiang Ni, Baoliang
Published in
Technology in Cancer Research & Treatment
Background: This study was designed to explore the effects of hsa-miR-9-5p on radiotherapy sensitivity of nasopharyngeal carcinoma (NPC) by targeting hexokinase 2 (HK2). Methods: The levels of hsa-miR-9-5 and HK2 in NPC patients and radiosensitive and resistant cells were determined using qRT-PCR. The dual luciferase reporter gene system was used t...
Lv, Qing Xia, Qinghua Li, Anshu Wang, Zhiyong
Published in
Technology in Cancer Research & Treatment
This study was performed to investigate the role of interleukin-1 receptor accessory protein (IL1RAP) in stomach carcinoma in vitro and in vivo, determine whether IL1RAP knockdown could regulate the development of stomach carcinoma, and elucidate the relationship between IL1RAP knockdown and inflammation by tumor microenvironment-related inflammato...
Li, Tao Li, Na Wang, Lei Li, Jia Zhang, Xin
Published in
Technology in Cancer Research & Treatment
Osteosarcoma is the most common primary bone malignancy. We aim to investigate that role of M-phase phosphoprotein 8 (MPP8) on proliferation and apoptosis in osteosarcoma. Briefly, the current research reported an in vitro study investigating the role MPP8 in OS tumorigenesis. Consequently, we found that the MPP8 expression was upregulated in osteo...
Chen, Yanxia Chen, Dong Wang, Jing Zhang, Yu Zhang, Ji Chen, Bing Chen, Yaru Zhang, Yi Ma, Cailing
Published in
Technology in Cancer Research & Treatment
Cervical cancer is one of the most malignant tumors in women, particularly those in rural and remote areas. Its underlying molecular mechanisms, including the functions of non-coding RNA (ncRNAs), require more extensive investigation. In this study, high throughput transcriptome sequencing (RNA-seq) was used to identify differentially expressed lnc...
Chen, Yanfang Chen, Zheng Mo, Jian Pang, Mao Chen, Zihao Feng, Feng Xie, Peigen Yang, Bu
Published in
Technology in Cancer Research & Treatment
Background: Bone metastasis is a leading cause of the high mortality rate of prostate cancer (PCa), but curative strategies remain lacking. Recent studies suggest long non-coding RNAs (lncRNAs) may be potential targets to develop drugs. However, PCa bone metastasis-specifically-related lncRNAs were rarely reported. This study aimed to identify cruc...
