Redondo, Juliana Bailey, Steven Kemp, Kevin C Scolding, Neil J Rice, Claire M
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Stem cells translational medicine
Bone marrow (BM)-derived mesenchymal stromal cells (MSCs) are promising candidates for cell-based therapy for several immune-mediated inflammatory diseases (IMIDs) due to their multiplicity of immunomodulatory and reparative properties and favorable safety profile. However, although preclinical data were encouraging, the clinical benefit demonstrat...
Semenza, Gregg L
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Stem cells translational medicine
Many advanced human cancers contain regions of intratumoral hypoxia, with O2 gradients extending to anoxia. Hypoxia-inducible factors (HIFs) are activated in hypoxic cancer cells and drive metabolic reprogramming, vascularization, invasion, and metastasis. Hypoxia induces breast cancer stem cell (BCSC) specification by inducing the expression and/o...
Finkel, Dina A Malfa, Ana Liao, Yanling Purohit, Deepti Hu, Furong Sulaymankhil, Davud Abhishek Narra, Sai Hussein, Karen Subbian, Selvakumar Cairo, Mitchell S
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Stem cells translational medicine
Intraventricular hemorrhage (IVH) is a severe complication of preterm birth associated with white matter injury (WMI) and reduced neurogenesis. IVH commonly arises from the germinal matrix, a highly cellular, transient structure, where all precursor cells are born, proliferate, and migrate during brain development. IVH leads to reduced progenitor c...
Stavely, Rhian Ott, Leah C Sahakian, Lauren Rashidi, Niloufar Sakkal, Samy Nurgali, Kulmira
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Stem cells translational medicine
Oxidative stress is involved in many gastrointestinal (GI) disorders as either the primary pathogenesis (radiation, chemotherapy, toxicity, ischemia-reperfusion) or a secondary driving force of disease progression (inflammation and diabetes). The GI tract is innervated intrinsically by the enteric nervous system (ENS) with a diverse role in maintai...
Olaechea, Allinson Benabdellah, Karim Vergara-Buenaventura, Andrea Gómez-Melero, Sara Cafferata, Emilio A Meza-Mauricio, Jonathan Padial-Molina, Miguel Galindo-Moreno, Pablo
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Stem cells translational medicine
The development of extracellular vesicles (EVs) therapies has revolutionized personalized medicine, opening up new possibilities for treatment. EVs have emerged as a promising therapeutic tool within this field due to their crucial role in intercellular communication across various cell types and organisms. This systematic review aims to evaluate t...
Tsiapalis, Dimitrios Floudas, Achilleas Tertel, Tobias Boerger, Verena Giebel, Bernd Veale, Douglas J Fearon, Ursula O'Driscoll, Lorraine
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Stem cells translational medicine
Currently available therapies for rheumatoid arthritis (RA) are inadequate to alleviate the inflammation and reduce joint damage. While the immune-regulatory effect of human mesenchymal/stromal stem cells (MSCs) extracellular vesicles (EVs) has been tested in many inflammation-related diseases, little is known regarding their effect on patients wit...
Zang, Li Li, Yijun Hao, Haojie Liu, Jiejie Zhang, Qian Gao, Fei Wang, Haibin Chen, Yulong Gu, Weijun Du, Jin
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Stem cells translational medicine
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been proved a promising clinical strategy for the treatment of diabetes, and time in range (TIR) has been demonstrated a new metric of glycemic control links to diabetes complications. To further assess the therapeutic effect of UC-MSCs on TIR, a phase II study investigating the efficacy ...
Terada, Eisaku Bamba, Yohei Takagaki, Masatoshi Kawabata, Shuhei Tachi, Tetsuro Nakamura, Hajime Nishida, Takeo Kishima, Haruhiko
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Stem cells translational medicine
Cerebral organoids (COs) are derived from human-induced pluripotent stem cells in vitro and mimic the features of the human fetal brain. The development of COs is largely dependent on "self-organization" mechanisms, in which differentiating cells committed to cortical cells autonomously organize into the cerebral cortex-like tissue. However, extrin...
Ye, Yong-Shun Chen, Di-Fei Liu, Ming Luo, Yu-Long Chen, Huan-Jie Zeng, Hai-Kang Liu, Jing-Wei Zhu, Yi-Ping Song, Xin-Yu Lin, Chang-Qin
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Stem cells translational medicine
Airway epithelium defects are a hallmark of recurrent benign tracheal stenosis (RBTS). Reconstructing an intact airway epithelium is of great importance in airway homeostasis and epithelial wound healing and has great potential for treating tracheal stenosis. An experimental study was conducted in canines to explore the therapeutic effect of autolo...
Seebach, Caroline Nau, Christoph Henrich, Dirk Verboket, Rene Bellen, Marlene Frischknecht, Nadine Moeck, Vivien Eichler, Kathrin Horlohé, Kay Hajo Schmidt Hoffmann, Reinhard
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Stem cells translational medicine
Proximal humerus fractures are common in an aging population. The standard operative treatment is open reduction internal fixation (ORIF) using an angular stable plate. However, this procedure has complications such as a relatively high rate of secondary dislocation, humeral head necrosis or nonunion caused by delayed bony consolidation. Autologous...
