Rahmani, N. R. Belluomo, R. Kruyt, M. C. Gawlitta, D. Joosten, L. A. B. Weinans, H. Croes, M.
Published in
Stem Cell Reviews and Reports
Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts occur during specific immune training of macrophages that affect their functional state, resulting in heightened (trained) or reduced (tolerant) responses upon exposure to a second stimulus. This is known ...
Zhang, Yiran Zhang, Junni Lesani, Pooria Lu, Zufu Zreiqat, Hala
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Stem Cell Reviews and Reports
The regenerative function of stem cells is compromised when the proportion of senescent stem cells increases with ageing advance. Therefore, combating stem cell senescence is of great importance for stem cell-based tissue engineering in the elderly, but remains largely unexplored. Osteopontin (OPN), a glycosylated phosphoprotein, is one of the key ...
Poulos, Michael G. Ramalingam, Pradeep Winiarski, Agatha Gutkin, Michael C. Katsnelson, Lizabeth Carter, Cody Pibouin-Fragner, Laurence Eichmann, Anne Thomas, Jean-Leon Miquerol, Lucile
...
Published in
Stem Cell Reviews and Reports
In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of the hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing secreted and membrane-bound paracrine signals. Within the BM, distinct vascular arteriole, transitional, and sinusoidal EC subtypes display unique paracrine expression prof...
Carlander, Amanda-Louise Fenger Gundestrup, Anders Kierkegaard Jansson, Per Marcus Follin, Bjarke Hoeeg, Cecilie Kousholt, Birgitte Saima Larsen, Rasmus Tolstrup Jakobsen, Kathrine Kronberg Rimborg, Susie Fischer-Nielsen, Anne
...
Published in
Stem Cell Reviews and Reports
Background Mesenchymal stromal/stem cells (MSCs) have been suggested for salivary gland (SG) restoration following radio-induced salivary gland damage. This study aimed to determine the safety and effectiveness of MSC therapy on radio-induced SG damage and hypofunction in preclinical in vivo studies. Methods PubMed and EMBASE were systematically se...
Di, Tiankai Feng, Chao Wang, Lulu Xu, Jinlong Du, Yang Cheng, Baixiang Chen, Yujiang Wu, Lian
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Stem Cell Reviews and Reports
Background Dental pulp regeneration therapy is a challenge to achieve early vascularization during treatment. Studying the regulatory mechanisms of vascular formation during human dental pulp development may provide insights for related therapies. In this study, we utilized single-cell sequencing analysis to compare the gene expression of dental pu...
Theodosaki, Astero Maria Tzemi, Maria Galanis, Nikiforos Bakopoulou, Athina Kotsiomiti, Eleni Aggelidou, Eleni Kritis, Aristeidis
Published in
Stem Cell Reviews and Reports
The aim of the study is to determine the effectiveness of stem cells in scaffolds in the treatment of bone deficits, in regard of bone regeneration, safety, rehabilitation and quality of life in humans. The systematic review was conducted in accordance with PRISMA 2020. A systematic search was conducted in three search engines and two registries la...
Smith, Emily J. Beaumont, Ross E. Dudhia, Jayesh Guest, Deborah J.
Published in
Stem Cell Reviews and Reports
Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contributes to fibrotic healing by disrupting tenocyte activity, with the NF-κB pathway being identified as a...
Ahmed, Sarah Hamdy AlMoslemany, Mohamed Atef Witwer, Kenneth Whitaker Tehamy, Ahmed Gamal El-Badri, Nagwa
Published in
Stem Cell Reviews and Reports
Background COVID-19 rapidly escalated into a worldwide pandemic with elevated infectivity even from asymptomatic patients. Complications can lead to severe pneumonia and acute respiratory distress syndrome (ARDS), which are the main contributors to death. Because of their regenerative and immunomodulatory capacities, stem cells and their derived ex...
Che, Dehui Xiang, Xinjian Xie, Juan Chen, Zenghong Bao, Qiong Cao, Dongsheng
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Stem Cell Reviews and Reports
Chronic trauma in diabetes is a leading cause of disability and mortality. Exosomes show promise in tissue regeneration. This study investigates the role of exosomes derived from adipose stem cells (ADSC-Exos) in angiogenesis. MiRNA-seq analysis revealed significant changes in 47 genes in human umbilical vein endothelial cells (HUVECs) treated with...
Kulus, Magdalena Farzaneh, Maryam Bryja, Artur Zehtabi, Mojtaba Azizidoost, Shirin Abouali Gale Dari, Mahrokh Golcar-Narenji, Afsaneh Ziemak, Hanna Chwarzyński, Mikołaj Piotrowska–Kempisty, Hanna
...
Published in
Stem Cell Reviews and Reports
Epithelial-mesenchymal transition (EMT) is a crucial process with significance in the metastasis of malignant tumors. It is through the acquisition of plasticity that cancer cells become more mobile and gain the ability to metastasize to other tissues. The mesenchymal-epithelial transition (MET) is the return to an epithelial state, which allows fo...
