Fazzalari, Nicola L
Published in
Seminars in cell & developmental biology
Bone remodeling is an active process throughout the skeleton. The concept of bone turnover surface has been developed and reported in the peer reviewed literature as the quotient of formation surface/resorption surface and is significantly lower in hip fracture. It is necessary to identify the molecular drivers of these changes in bone turnover. Fa...
Croker, Ben A Kiu, Hiu Nicholson, Sandra E
Published in
Seminars in cell & developmental biology
The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling. In this review we focus on the mechanics of SOCS action and th...
Wei, Lai Laurence, Arian O'Shea, John J
Published in
Seminars in cell & developmental biology
T cell development and differentiation is carefully orchestrated by a series of cytokines. The importance of STAT family proteins in mediating signals by these cytokines is well-known, but new information on the role of STATs in novel aspects of T cell function and T cell subsets continues to accumulate. Recent studies have placed Stat5a/b and Stat...
Tony Hunter
Published in
Seminars in Cell and Developmental Biology
Triplett, Jw David Feldheim
Published in
Seminars in Cell and Developmental Biology
The axonal connections between the retina and its midbrain target, the superior colliculus (SC), is mapped topographically, such that the spatial relationships of cell bodies in the retina are maintained when terminating in the SC. Topographic map development uses a Cartesian mapping system such that each axis of the retina is mapped independently....
