Toufektchan, Eléonore Lejour, Vincent Durand, Romane Giri, Neelam Draskovic, Irena Bardot, Boris Laplante, Pierre Jaber, Sara Alter, Blanche P Londono-Vallejo, José-Arturo
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Published in
Science advances
Dyskeratosis congenita is a cancer-prone inherited bone marrow failure syndrome caused by telomere dysfunction. A mouse model recently suggested that p53 regulates telomere metabolism, but the clinical relevance of this finding remained uncertain. Here, a germline missense mutation of MDM4, a negative regulator of p53, was found in a family with fe...
Green, A. S. Maciel, T. T. Hospital, M.-A. Yin, C. Mazed, F. Townsend, E. C. Pilorge, S. Lambert, M. Paubelle, E. Jacquel, A.
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Published in
Science Advances
Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is frequently detected in acute myeloid leukemia (AML) patients and is associated with a dismal long-term prognosis. FLT3 tyrosine kinase inhibitors provide short-term disease control, but relapse invariably occurs within months. Pim protein kinases are oncogenic FLT3-ITD targets exp...
Pang, Hong-Bo Braun, Gary B Ruoslahti, Erkki
Published in
Science advances
Cell-penetrating peptides (CPPs) have been widely used to deliver nanomaterials and other types of macromolecules into mammalian cells for therapeutic and diagnostic use. Cationic CPPs that bind to heparan sulfate (HS) proteoglycans on the cell surface induce potent endocytosis; however, the role of other surface receptors in this process is unclea...
Rash, Brian G Ackman, James B Rakic, Pasko
Published in
Science advances
Cortical columns are basic cellular and functional units of the cerebral cortex that are malformed in many brain disorders, but how they initially develop is not well understood. Using an optogenetic sensor in the mouse embryonic forebrain, we demonstrate that Ca(2+) fluxes propagate bidirectionally within the elongated fibers of radial glial cells...
Fang, Chen Fu, Liang
Published in
Science advances
We discover new types of quantum anomalies in two-dimensional systems with time-reversal symmetry (T) and discrete rotation symmetry with order of n = 2, 4, and 6 (Cn ). The new anomalous states have n flavors of massless Dirac fermions protected by T and Cn , whereas any two-dimensional lattices having the two symmetries must have a multiple of 4,...
Venderley, Jordan Kim, Eun-Ah
Published in
Science Advances
Cooper pairs with a finite center-of-mass momentum form a remarkable state in which the superconducting order parameter is modulated periodically in space. Although intense interest in such a “pair-density wave” (PDW) state has emerged due to recent discoveries in high T c superconductors, there is little theoretical understanding of the mechanism ...
Pelc, D Popčević, P Požek, M Greven, M Barišić, N
Published in
Science advances
The discovery of high-temperature superconductivity in cuprates ranks among the major scientific milestones of the past half century, yet pivotal questions regarding the complex phase diagram of these materials remain unanswered. Generally thought of as doped charge-transfer insulators, these complex oxides exhibit pseudogap, strange-metal, superco...
Geng, Yina van Anders, Greg Dodd, Paul M. Dshemuchadse, Julia Glotzer, Sharon C.
Published in
Science Advances
Throughout the physical sciences, entropy stands out as a pivotal but enigmatic concept that, in materials design, typically takes a backseat to energy. Here, we demonstrate how to precisely engineer entropy to achieve desired colloidal crystals via particle shapes that, importantly, can be made in the laboratory. We demonstrate the inverse design ...
Estrada Saldaña, J. C. Žitko, R. Cleuziou, J. P. Lee, E. J. H. Zannier, V. Ercolani, D. Sorba, L. Aguado, R. De Franceschi, S.
Published in
Science Advances
A semiconductor nanowire with strong spin-orbit coupling in proximity to a superconductor is predicted to display Majorana edge states emerging under a properly oriented magnetic field. The experimental investigation of these exotic states requires assessing the one-dimensional (1D) character of the nanowire and understanding the superconducting pr...
Erwan Poivet Narmin Tahirova Zita Peterlin Lu Xu Dong-Jing Zou Terry Acree Stuart Firestein
Published in
Science Advances
Crucial for any hypothesis about odor coding is the classification and prediction of sensory qualities in chemical compounds. The relationship between perceptual quality and molecular structure has occupied olfactory scientists throughout the 20th century, but details of the mechanism remain elusive. Odor molecules are typically organic compounds o...
