Willis, Mary D Schrank, David Xu, Chunxue Harris, Lena Ritz, Beate R Hill, Elaine L Hystad, Perry
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Science advances
More than 11 million Americans reside within 150 meters of a highway, an area of high air pollution exposure. Traffic congestion further contributes to environmental pollution (e.g., air and noise), but its unique importance for population health is unclear. We hypothesized that degraded environmental quality specifically from traffic congestion ha...
Wass, Amanda B Krishna, Benjamin A Herring, Laura E Gilbert, Thomas S K Nukui, Masatoshi Groves, Ian J Dooley, Abigail L Kulp, Katherine H Matthews, Stephen M Rotroff, Daniel M
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Science advances
Cytomegalovirus (CMV) reactivation from latency following immune dysregulation remains a serious risk for patients, often causing substantial morbidity and mortality. Here, we demonstrate the CMV-encoded G protein-coupled receptor, US28, in coordination with cellular Ephrin receptor A2, attenuates mitogen-activated protein kinase signaling, thereby...
Choi, Insup Heaton, George R Lee, You-Kyung Yue, Zhenyu
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Science advances
Autophagy clears protein aggregates, damaged cellular organelles, and pathogens through the lysosome. Although autophagy is highly conserved across all cell types, its activity in each cell is specifically adapted to carry out distinct physiological functions. The role of autophagy in neurons has been well characterized; however, in glial cells, it...
Ha, Jeongmin Kim, Bum Suk Min, Byungkuk Nam, Juhyeon Lee, Jae-Geun Lee, Minhyung Yoon, Byoung-Ha Choi, Yoon Ha Im, Ilkyun Park, Jung Sun
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Published in
Science Advances
Desmoplakin may be an evolutionary link between cellular reprogramming in mammals and tissue regeneration in lower vertebrates.
Wang, Yingxue Ramos, Maria Jefferson, Matthew Zhang, Weijiao Beraza, Naiara Carding, Simon Powell, Penny P Stewart, James P Mayer, Ulrike Wileman, Thomas
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Science advances
The delivery of pathogens to lysosomes for degradation provides an important defense against infection. Degradation is enhanced when LC3 is conjugated to endosomes and phagosomes containing pathogens to facilitate fusion with lysosomes. In phagocytic cells, TLR signaling and Rubicon activate LC3-associated phagocytosis (LAP) where stabilization of ...
Duan, Jiaru Liu, Yanping Zhang, Yongqing Chen, Zeng Xu, Xuehui Ye, Lei Wang, Zukun Yang, Yang Zhang, Delong Zhu, Haiming
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Science advances
Upconverting infrared light into visible light via the triplet-triplet annihilation process in solid state is important for various applications including photovoltaics, photodetection, and bioimaging. Although inorganic semiconductors with broad absorption and negligible exchange energy loss have emerged as promising alternative to molecular sensi...
Zhu, Weikun Satterthwaite, Peter F Jastrzebska-Perfect, Patricia Brenes, Roberto Niroui, Farnaz
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Science advances
Deterministic, pristine, and scalable integration of individual nanoparticles onto arbitrary surfaces is an ongoing challenge, yet essential for harnessing their unique properties for functional nanoscale devices. To address this challenge, we present a versatile technique where spatially arranged nanoparticles assembled in a topographical template...
Xie, Jun Han, Yongchao Liang, Yufeng Peng, Lei Wang, Tao
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Science advances
Histamine is an important monoamine neurotransmitter that regulates multiple physiological activities in both vertebrates and invertebrates. Clearance and recycling of histamine are critical for sustaining histaminergic transmission. However, unlike other monoamine neurotransmitters, a histamine-specific transporter capable of clearing histamine fr...
Chen, Lu Zhu, Wenqi Huo, Pengcheng Song, Junyeob Lezec, Henri J Xu, Ting Agrawal, Amit
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Science advances
The ability to control the instantaneous state of light, from high-energy pulses down to the single-photon level, is an indispensable requirement in photonics. This has, for example, facilitated spatiotemporal probing and coherent control of ultrafast light-matter interactions, and enabled capabilities such as generation of exotic states of light w...
Zhu, Shanshan Li, Yuanheng Yelemulati, Huoerhute Deng, Xinping Li, Yongcheng Wang, Jingjing Li, Xiaojian Li, Guanglin Gkoupidenis, Paschalis Tai, Yanlong
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Science advances
Flexible tactile neuromorphic devices are becoming important as the impetus for the development of human-machine collaboration. However, accomplishing and further transcending human intelligence with artificial intelligence still confront many barriers. Here, we present a self-powered stretchable three-dimensional remote tactile device (3D-RTD) tha...
