Chip-based laser with 1-hertz integrated linewidth
...
Published in Science Advances
This work bridges semiconductor integrated optics and precision metrology to demonstrate an extremely low-noise chip-based laser.
Chip-based laser with 1-hertz integrated linewidth
...
ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus.
...
Published in Science advances
B cells orchestrate autoimmune responses in patients with systemic lupus erythematosus (SLE), but broad-based B cell-directed therapies show only modest efficacy while blunting humoral immune responses to vaccines and inducing immunosuppression. Development of more effective therapies targeting pathogenic clones is a currently unmet need. Here, we ...
Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force gener...
Published in Science advances
Muscle weakness associated with sarcopenia is a major contributor to reduced health span and quality of life in the elderly. However, the underlying mechanisms of muscle weakness in aging are not fully defined. We investigated the effect of oxidative stress and aging on specific molecular mechanisms involved in muscle force production in mice and s...
LC3-associated endocytosis and the functions of Rubicon and ATG16L1.
Published in Science advances
LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5-positive endosomes, using a portion of the canonical autophagy pathway. LANDO was initially discovered in a murine model of Alzheimer's disease as a critical regulator of amyloid-β...
Barriers to gene flow in the deepest ocean ecosystems: Evidence from global population genomics of a cosmopolitan amphip...
Published in Science advances
The deepest marine ecosystem, the hadal zone, hosts endemic biodiversity resulting from geographic isolation and environmental selection pressures. However, the pan-ocean distribution of some fauna challenges the concept that the hadal zone is a series of isolated island-like habitats. Whether this remains true at the population genomic level is un...
Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling
Published in Science Advances
Inhibition of hNKCC1 involves a long-distance conformational coupling, leading to arrest of the cotransporter.
De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV...
Published in Science advances
The frequent occurrence of viral variants is a critical problem in developing antiviral prophylaxis and therapy; along with stronger recognition of host cell receptors, the variants evade the immune system-based vaccines and neutralizing agents more easily. In this work, we focus on enhanced receptor binding of viral variants and demonstrate genera...
Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.
...
Published in Science advances
Quiescent leukemic cells survive chemotherapy, with translation changes. Our data reveal that FXR1, a protein amplified in several aggressive cancers, is elevated in quiescent and chemo-treated leukemic cells and promotes chemosurvival. This suggests undiscovered roles for this RNA- and ribosome-associated protein in chemosurvival. We find that FXR...
Unconventional superconductivity in topological Kramers nodal-line semimetals
...
Published in Science Advances
Broken time-reversal symmetry ruthenium silicides that host Kramers- and hourglass fermions promise topological superconductivity.
A population-based cohort study of traffic congestion and infant growth using connected vehicle data.
Published in Science advances
More than 11 million Americans reside within 150 meters of a highway, an area of high air pollution exposure. Traffic congestion further contributes to environmental pollution (e.g., air and noise), but its unique importance for population health is unclear. We hypothesized that degraded environmental quality specifically from traffic congestion ha...
