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CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of anky...

Published in Rheumatology (Oxford, England)

Our results suggest the involvement of a particular antigen-specific subset of CD8+ T cells in AS pathogenesis, confirming and expanding earlier findings. The high similarity of the clonotypes with the ones found in ReA implies common mechanisms for the initiation of the diseases.

Early response to therapy predicts 6-month and 1-year disease activity outcomes in psoriatic arthritis patients.

Published in Rheumatology (Oxford, England)

Three months after implementation of therapy in PsA, it is already possible to evaluate the potential for accomplishing therapeutic goals. This substantiates the choice of the 3-month assessment as essential for treatment adaptations.

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation.

Published in Rheumatology (Oxford, England)

Radiographic knee osteoarthritis impacts multiple dimensions of health-related quality of life: data from the Osteoarthr...

Published in Rheumatology (Oxford, England)

Radiographic knee OA is significantly associated with worse HRQoL across most dimensions of health.

Gout misdiagnosis due to dual-energy computed tomography artefact.

Published in Rheumatology (Oxford, England)

Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment.

Published in Rheumatology (Oxford, England)

Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which if not promptly treated, can lead rapidly to critical illness and death. HLH is termed macrophage activation syndrome (MAS) when associated with rheumatic disease (where it is best characterized in systemic JIA) and secondary HLH (sHLH) when associated with other trigg...

Patient acceptable symptom state in scleroderma: results from the tocilizumab compared with placebo trial in active diff...

Published in Rheumatology (Oxford, England)

PASS may be used as a patient-centred outcome in SSc, especially as a 7-point Likert scale. Further validation is required to determine the utility as an outcome measure in trials and clinical practice.

Prevalence and predictors of tumour necrosis factor inhibitor persistence in psoriatic arthritis.

Published in Rheumatology (Oxford, England)

Patients with PsA who are female and have metabolic syndrome-related co-morbidities have lower TNFi persistence. Although persistence was lower in patients who had switched to a second TNFi, a substantial proportion of these cases responded, advocating switching to a second TNFi as a valid therapeutic strategy.

The revised Bristol Rheumatoid Arthritis Fatigue measures and the Rheumatoid Arthritis Impact of Disease scale: validati...

Published in Rheumatology (Oxford, England)

Across six European countries, the BRAF-MDQ identifies the same four aspects of fatigue, and along with the RAID, shows strong factor structure and internal consistency and moderate-good construct validity. The revised BRAF-NRS V2 shows improved construct validity and replaces the original.

Is diffuse idiopathic skeletal hyperostosis a disease or a syndrome?

Published in Rheumatology (Oxford, England)