Published in Rheumatology (Oxford, England)
Our results suggest the involvement of a particular antigen-specific subset of CD8+ T cells in AS pathogenesis, confirming and expanding earlier findings. The high similarity of the clonotypes with the ones found in ReA implies common mechanisms for the initiation of the diseases.
Published in Rheumatology (Oxford, England)
Three months after implementation of therapy in PsA, it is already possible to evaluate the potential for accomplishing therapeutic goals. This substantiates the choice of the 3-month assessment as essential for treatment adaptations.
Published in Rheumatology (Oxford, England)
Published in Rheumatology (Oxford, England)
Radiographic knee OA is significantly associated with worse HRQoL across most dimensions of health.
Published in Rheumatology (Oxford, England)
Published in Rheumatology (Oxford, England)
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which if not promptly treated, can lead rapidly to critical illness and death. HLH is termed macrophage activation syndrome (MAS) when associated with rheumatic disease (where it is best characterized in systemic JIA) and secondary HLH (sHLH) when associated with other trigg...
Published in Rheumatology (Oxford, England)
Published in Rheumatology (Oxford, England)
PASS may be used as a patient-centred outcome in SSc, especially as a 7-point Likert scale. Further validation is required to determine the utility as an outcome measure in trials and clinical practice.
Published in Rheumatology (Oxford, England)
Published in Rheumatology (Oxford, England)
Patients with PsA who are female and have metabolic syndrome-related co-morbidities have lower TNFi persistence. Although persistence was lower in patients who had switched to a second TNFi, a substantial proportion of these cases responded, advocating switching to a second TNFi as a valid therapeutic strategy.
