Published in Reproductive Sciences
ObjectiveIntegrin α11β1 is a collagen receptor specific to fibroblasts that regulates myofibroblast differentiation. We sought to determine whether α11β1 is expressed in myometrium and fibroids and whether tissue expression varies.DesignComparison of α11 in human myometrium and fibroids using Western blot and RNA in situ hybridization.Materials and...
Published in Reproductive Sciences
ObjectivesThe accurate distinction of leiomyoma from leiomyosarcoma is essential for patient management. However, the distinction can be difficult to make, particularly in tissue biopsy samples. Immunohistochemistry has been established as a useful technique to aid in the diagnosis of malignancies. The advantages of immunohistochemical studies are ...
Published in Reproductive Sciences
Embryo implantation is a complex process that involves synchronized crosstalk between a receptive endometrium and a functional blastocyst. It can take place only during the window of implantation, a period when a series of changes in gene expression occur in the endometrium to accept the embryo. As modulators of gene expression, microRNAs (miRNAs) ...
Published in Reproductive Sciences
Complex interplay of innate and adaptive immune cells has been implicated in the establishment, maintenance, and progression of endometriosis. Defining the identity, activation state, and functional role of immune cells during lesion establishment will provide invaluable insight into the underlying mechanisms of disease. This study utilized a trans...
Published in Reproductive Sciences
ObjectiveTo evaluate the biocompatibility of silk gel for cervical injection.Study DesignSilk gel was injected into the cervix of pregnant rats on day 13 (n = 11) and harvested at day 17. Histology of silk gel was compared with suture controls. Also, human cervical fibroblasts were cultured on silk gel and tissue culture plastic (TCP) in vitro. Cel...
Published in Reproductive Sciences
The combination of a progestin such as norethindrone acetate (NETA) reducing the ovarian estrogen production with a steroid sulfatase (STS) inhibitor (STS-I) decreasing the local estrogen production could result in a new treatment option for endometriosis. The study reported was a randomized, double-blind, and placebo-controlled study to investigat...
Published in Reproductive Sciences
Following an investigation by the University of Florida providing evidence of the senior (last) author’s use of falsified or fabricated data in Figures 1, 2 and 3, the above-mentioned article has been retracted. None of the other authors, Tannaz Toloubeydokhti, Qun Pan, Xiaoping Luo, and Orhan Bukulmez, were the subject of the investigation.
Published in Reproductive Sciences
ObjectiveThis study is to assess the correlation of risk, injury, failure, loss, and end-stage renal failure (RIFLE) classification with hospital mortality in intensive care unit (ICU) obstetric patients and to evaluate the relation of acute kidney injury (AKI) to other risk factors.MethodsThe 4 stages of RIFLE (nonacute renal failure, risk, injury...
Published in Reproductive Sciences
The transient receptor potential channels are membrane-binding proteins that are nonselectively permeable for cations, such as Ca2+ and Mg2+, in numerous mammalian cells. The extracellular or intracellular ions play key roles in physiological functions including muscle contraction, cytokine production, insulin release, and apoptosis. Although trans...
Published in Reproductive Sciences
The objective of this study was to determine how often an elevated cancer antigen (CA) 19-9 (≥ 37 U/mL) was present during the preoperative evaluation of women with a mature cystic teratoma (MCT). This was a retrospective, consecutive case series (N = 139) of histologically proven MCT treated at Montefiore Medical Center from 1997 to 2008. Data wer...
