Toll-like receptors and pregnancy.
Published in Reproductive sciences (Thousand Oaks, Calif.)
Activation of toll-like receptors 2 or 3 and preterm delivery in the mouse.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The objective of this study is to test whether the activation of toll-like receptors (TLRs) 2 and 3 (innate immune receptors for gram-positive and viral pathogens, respectively) can induce preterm delivery. One uterine horn of preterm pregnant CD-1 mice at approximately 75% of gestation was injected with TLR-2 ligands (lipoteichoic acid [LTA] or pe...
High expression of human telomerase reverse transcriptase in high-grade intraepithelial neoplasia and carcinoma of uteri...
Published in Reproductive sciences (Thousand Oaks, Calif.)
Most of cervical intraepithelial neoplasia 1 (CIN 1) will regress and 12% to 40% of high-grade CIN may progress to squamous cell carcinoma (SCC) of the uterine cervix. However, the differentiation of CIN 1 and high-grade CIN is sometimes controversial among pathologists. Human telomerase reverse transcriptase (hTERT) is therefore applied to detect ...
Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and v...
Published in Reproductive sciences (Thousand Oaks, Calif.)
The authors demonstrate expression of the vitamin D receptor (VDR) and its hydroxylases in the endometrium and ovaries of women with and without endometriosis and endometrial or ovarian cancer. Immunohistochemistry showed strong staining of the VDR in endometriosis and endometrial cancer, with the most intense staining in epithelial cells. The VDR ...
The expression of GLUT8, GLUT9a, and GLUT9b in the mouse testis and sperm.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The objective of this study is to confirm the precise glucose transporter (GLUT) 8 localization and determine the expression of GLUT9a and GLUT9b by Western blot and confocal and immunoelectron microscopy in the mouse testis and sperm. GLUT8, GLUT9a, and GLUT9b proteins are expressed in the most intraseminiferous tubula cells and Leydig cells. GLUT...
Magnetic resonance signal characteristics of the cervix as pregnancy advances.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The objective of this study is to describe magnetic resonance (MR) signal intensity (SI) changes in the cervix during pregnancy. This is an observational cohort study of women with a history of preterm delivery. MR imaging sequences were performed every 3 to 4 weeks. Using 8 regions of interest, the SIs are quantified and analyzed with respect to g...
Endothelin-1 attenuates apoptosis in cultured trophoblasts from term human placentas.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The authors test the hypothesis that endothelin-1 (ET-1) modulates apoptosis in human term trophoblasts. Primary cultures of cytotrophoblasts from term human placentas (n = 5) were cultured for 16 hours total or 24 hours prior to harvest at 72 hours in atmospheres of
Human nonmetastatic clone 23 type 1 gene suppresses migration of cervical cancer cells and enhances the migration inhibi...
Published in Reproductive sciences (Thousand Oaks, Calif.)
The authors investigate the effects of human nonmetastatic clone 23 type 1 (nm23-H1 ) gene and fungal immunomodulatory protein-Ganoderma tsugae (FIP-gts) on the metastatic potential of cervical cancer cells and assess whether nm23-H1 can influence the action of FIP-gts using cell migration and invasion assays and gelatin zymography. The nm23-H1 gen...
A tumor necrosis factor-alpha promoter polymorphism and pregnancy complications: results of a prospective cohort study i...
Published in Reproductive sciences (Thousand Oaks, Calif.)
The purpose of this article is to investigate the frequency of the tumor necrosis factor-alpha (TNF-alpha) -308 G/A single nucleotide polymorphism in women with intrauterine fetal death, preeclampsia, preterm delivery, and small-for-gestational-age (SGA) infants. In a prospective cohort study, DNA from 1652 consecutive pregnant women was analyzed f...
Review article: stem cells in human reproduction.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The derivation of human embryonic stem (hES) cells heralds a new era in stem cell research, generating excitement for their therapeutic potential in regenerative medicine. Pioneering work of embryologists, developmental biologists, and reproductive medicine practitioners in in vitro fertilization clinics has facilitated hES cell research. This revi...
