Menon, Ramkumar Williams, Scott M Fortunato, Stephen J
Published in
Reproductive sciences (Thousand Oaks, Calif.)
The purpose of this study is to examine the racial differences between interleukin (IL)-1beta and IL-8 concentrations in the amniotic fluid of black and white women with spontaneous preterm birth (PTB). In this study, 350 amniotic fluid samples were collected: 165 PTB cases (37 weeks' gestation; 87 blacks and 98 whites). Amniotic fluid IL-1beta and...
Rizek, Rose M Watson, Carole S Keating, Sarah Tai, Hsin-Hsiung Challis, John R G Bocking, Alan D
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Prostaglandins play a central role in the stimulation and maintenance of both term and preterm labor. 15-Hydroxyprostaglandin dehydrogenase (PGDH), localized primarily to chorion trophoblasts, is the key enzyme responsible for the metabolism of prostaglandins. In preterm chorion, levels of PGDH protein and activity were lower when compared to term ...
Wierman, Margaret E Kohrt, Wendy M
Published in
Reproductive sciences (Thousand Oaks, Calif.)
The early discontinuation of the Women's Health Initiative trials of daily conjugated estrogens and medroxyprogesterone and of conjugated estrogens only was hailed as the "death to the use of hormone replacement regimens" in menopause. The analyses showed risks outweighing benefits of hormone therapy when given broadly to postmenopausal women. The ...
Reis, Fernando M Nascimento, Lívia L Tsigkou, Anastasia Ferreira, Márcia C Luisi, Stefano Petraglia, Felice
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Activin A and follistatin are growth factors produced by several organs, comprising the endometrium, where they modulate cell and tissue differentiation. In this study, the authors tested whether activin A and follistatin are measurable in menstrual blood and whether their concentrations change in women with dysfunctional uterine bleeding (DUB). Th...
Petropoulos, Sophie Kalabis, Grazyna M Gibb, William Matthews, Stephen G
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Multidrug resistance phosphoglycoprotein (ABCB1) has been shown to limit maternal-fetal transfer by actively excluding ABCB1 substrates. The authors have previously demonstrated a marked decrease in placental ABCB1 expression in the human and mouse with advancing gestation. In the present study, it is hypothesized that the decrease in ABCB1 express...
Wu, Yan Starzinski-Powitz, Anna Guo, Sun-Wei
Published in
Reproductive sciences (Thousand Oaks, Calif.)
The objective of this study is to determine whether trichostatin A (TSA) can suppress the invasiveness of 2 endometriotic cell lines known to be invasive and E-cadherin negative. The membrane invasion culture system was used to assess cell invasion using invasive and a noninvasive bladder cancer cell lines as positive and negative controls, respect...
Oktem, Ozgur Oktay, Kutluk
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Extracellular matrix plays a key role in cell growth, survival, and differentiation in a wide array of tissue types through integrin-mediated signaling pathways and its interaction with growth factors. This study investigates the role of extracellular matrix and its interaction with activin-A on in vitro growth and survival of mouse preantral folli...
Kitao, Keisuke Yoshida, Shigeki Kennedy, Stephen Takemura, Naoya Sugimoto, Makoto Deguchi, Masashi Ohara, Noriyuki Maruo, Takeshi
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Endometrial cancer is associated with both EGFR and HER2 receptor activation. The EGFR and HER2 genes could be disease susceptibility candidate genes for this cancer. This study was conducted to investigate a possible association between EGFR and HER2 gene polymorphisms and endometrial cancer and the influence of these polymorphisms on the clinical...
Desai, Mina Gayle, Dave Han, Guang Ross, Michael G
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Maternal food restriction during pregnancy results in intrauterine growth-restricted (IUGR) newborns with significantly decreased plasma leptin levels. When nursed by ad libitum-fed controls, IUGR offspring exhibit hyperphagia with adult obesity, marked by increased percentage body fat and plasma leptin, suggesting altered anorexigenic pathways. Th...
van Kaam, K J A F Romano, A Dunselman, G A J Groothuis, P G
Published in
Reproductive sciences (Thousand Oaks, Calif.)
Deep infiltrating endometriosis is characterized by the presence of nodular lesions largely composed of fibromuscular tissue. Transforming growth factor beta 1 (TGF-beta1) is the cytokine most causatively associated with disorders characterized by fibrosis throughout the body. Therefore, the hypothesis was tested that mechanisms increasing the frac...
