Getting the message out: RNA interference of human papillomavirus.
Published in Reproductive sciences (Thousand Oaks, Calif.)
Serum cystatin C in pregnancies with normal and restricted fetal growth.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The objective of this study was to investigate circulating levels of cystatin C (an important endogenous marker of renal function) in mothers, fetuses, and neonates from intrauterine growth-restricted (IUGR; characterized by impaired nephrogenesis) and appropriate-for-gestational-age (AGA) pregnancies. Serum cystatin C levels were measured by enzym...
Strain differences in the impact of dietary restriction on fetal growth and pregnancy in mice.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The association between suboptimal intrauterine environment and developmental origins of adult health and disease is variable, suggesting that genotype may contribute to eventual outcome. The objective of this study was to characterize maternal and fetal responses to maternal dietary restriction during pregnancy in 2 phylogenetically distant strain...
Risk factors for placental abruption in an Asian population.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The objective of this study was to identify risk factors for placental abruption in an Asian population. The authors conducted a retrospective review of 37 245 Taiwanese women who delivered between July 1990 and December 2003. Pregnancies complicated by placenta previa, multiple gestation, and fetal anomalies were excluded. Multivariable logistic r...
Regulation of endothelial-dependent relaxation in human systemic arteries by SKCa and IKCa channels.
Published in Reproductive sciences (Thousand Oaks, Calif.)
Blockade of small-conductance Ca (2)(+)-activated K(+) channels (SK(Ca)) and intermediate conductance Ca(2)(+)-activated K(+) channels (IK(Ca)) can cause inhibition of endothelium-dependent hyperpolarizing factor (EDHF) in many vascular beds from animals, but there is a relative paucity of data in human vessels. Systemic arteries, isolated from wom...
Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells.
Published in Reproductive sciences (Thousand Oaks, Calif.)
Silencing the expression of human papillomavirus (HPV) oncoproteins should have therapeutic benefits for cervical cancer. The authors' objective was to study RNA interference of the HPV 18 E6/E7 bicistronic mRNA with E6 small interfering RNA (siRNA) and E7 siRNA and determine the effect of each siRNA on oncoprotein expression, resultant cell growth...
Nutrient restriction in utero induces remodeling of the vascular extracellular matrix in rat offspring.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The uterine environment may influence the development of chronic diseases later in life. The authors hypothesized that maternal nutritional restriction prenatally induces remodeling of offspring blood vessels such that they become stiff and contribute to the development of adult hypertension. To test this hypothesis, the authors studied the blood v...
Fetal hypercapnia in high-altitude acclimatized sheep: cerebral blood flow and cerebral oxygenation.
Published in Reproductive sciences (Thousand Oaks, Calif.)
The authors tested the hypothesis that in the high-altitude acclimatized fetus, hypercapnia has a significantly less effect on cerebral blood flow (CBF) and cerebral oxygenation than that in normoxic sea level controls. In the high-altitude acclimatized fetus (3801 m; maintained from day 30 of gestation to near term; n = 6), by use of a laser Doppl...
Orthostatic stress response during the menstrual cycle is unaltered in formerly preeclamptic women with low plasma volum...
Published in Reproductive sciences (Thousand Oaks, Calif.)
Plasma volume (PV) varies with the menstrual cycle not only in healthy parous controls (CON) but also in formerly preeclamptic women with a subnormal PV (LPV). It is unknown whether formerly preeclamptic women with LPV are more susceptible to orthostatic stress than healthy controls. In this study, the authors compared autonomic responses to acute ...
Interleukin 1beta and progesterone stimulate activin a expression and secretion from cultured human endometrial stromal ...
Published in Reproductive sciences (Thousand Oaks, Calif.)
Steroid hormones, cytokines, and growth factors have a major role in evoking local endometrial changes needed for trophoblast implantation. In the present study, the effect of interleukin-1beta (IL-1beta), 17-beta estradiol (E2), and progesterone (Pr) on activin A and follistatin (FS) secretion from cultured human endometrial stromal cells (HESCs) ...
