Ebrahimi, Behdad Shaarbaf Tawhai, Merryn H Kumar, Haribalan Burrowes, Kelly S Hoffman, Eric A Wilsher, Margaret L Milne, David Clark, Alys R
Published in
Pulmonary circulation
Pulmonary hypertension has multiple etiologies and so can be difficult to diagnose, prognose, and treat. Diagnosis is typically made via invasive hemodynamic measurements in the main pulmonary artery and is based on observed elevation of mean pulmonary artery pressure. This static mean pressure enables diagnosis, but does not easily allow assessmen...
McInnis, Micheal C Chow, Clement T Boutet, Alexandre Mafeld, Sebastian Granton, John McRae, Karen Donahoe, Laura de Perrot, Marc
Published in
Pulmonary circulation
Treatment options for chronic thromboembolic pulmonary hypertension (CTEPH) are rapidly expanding. The purpose of this study is to identify trends in CTEPH clinical trials and the publication of results. We performed a worldwide review of completed and ongoing clinical trials through searching the ClinicalTrials.gov database and the World Health Or...
Ahmed, Mohamed Zaghloul, Nahla Zimmerman, Prisca Casanova, Nancy G Sun, Xiaoguang Song, Jin H Hernon, Vivian Reyes Sammani, Saad Rischard, Franz Rafikova, Olga
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Published in
Pulmonary circulation
Pharmacologic interventions to halt/reverse the vascular remodeling and right ventricular dysfunction in pulmonary arterial hypertension (PAH) remains an unmet need. We previously demonstrated extracellular nicotinamide phosphoribosyltransferase (eNAMPT) as a DAMP (damage-associated molecular pattern protein) contributing to PAH pathobiology via TL...
Frantz, Robert P Benza, Raymond L Channick, Richard N Chin, Kelly Howard, Luke S McLaughlin, Vallerie V Sitbon, Olivier Zamanian, Roham T Hemnes, Anna R Cravets, Matt
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Published in
Pulmonary circulation
Aberrant kinase signaling that involves platelet-derived growth factor receptor (PDGFR) α/β, colony stimulating factor 1 receptor (CSF1R), and stem cell factor receptor (c-KIT) pathways may be responsible for vascular remodeling in pulmonary arterial hypertension. Targeting these specific pathways may potentially reverse the pathological inflammati...
Safdar, Zeenat Cho, Eunah
Published in
Pulmonary circulation
Spironolactone, a common diuretic used in the treatment of pulmonary arterial hypertension (PAH), improves cardiopulmonary hemodynamics by attenuating the adverse effects of hyperaldosteronism on endothelin type-B receptor function within pulmonary endothelial cells. Spironolactone has demonstrated vascular remodeling properties and reduced all-cau...
Potus, Francois Frump, Andrea L Umar, Soban R Vanderpool, Rebecca Al Ghouleh, Imad Lai, Yen-Chun
Published in
Pulmonary circulation
Each year the American Thoracic Society (ATS) Conference brings together scientists who conduct basic, translational and clinical research to present on the recent advances in the field of respirology. Due to the Coronavirus Disease of 2019 (COVID-19) pandemic, the ATS2020 Conference was held online in a series of virtual meetings. In this review, ...
Chen, Yuqin He, Wenjun Lu, Wenju Xing, Yue Bai, Jianling Yu, Hao Zhou, Jiawei Liang, Jingyi Chen, Jiyuan Hou, Chi
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Published in
Pulmonary circulation
Up to 30 May 2021, the cumulative number of patients diagnosed with corona virus disease-19 (COVID-19) globally has exceeded 170 million, with more than 152 million patients recovered from COVID-19. However, the long-term effect of the virus infection on the human body's function is unknown for convalescent patients. It was reported that about 63% ...
Wang, Lan Shen, Li Zhao, Ya-Lin Pudasaini, Bigyan Zhao, Qin-Hua Gong, Su-Gang Zhang, Rui Yuan, Ping He, Jing Luo, Ci-Jun
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Published in
Pulmonary circulation
Platelet distribution width has been recognized as risk predictors of idiopathic pulmonary arterial hypertension. This study aims to investigate whether in-hospital platelet distribution width would be useful to predict all-cause death in patients with severe pulmonary hypertension due to chronic lung diseases (CLD-PH). Early in-hospital platelet d...
Botros, Liza Jansen, Samara M A Ashek, Ali Spruijt, Onno A Tramper, Jelco Noordegraaf, Anton V Aman, Jurjan Harms, Hans de Man, Frances S Huisman, Marc C
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Published in
Pulmonary circulation
Pulmonary arterial hypertension is a heterogeneous group of diseases characterized by vascular cell proliferation leading to pulmonary vascular remodelling and ultimately right heart failure. Previous data indicated that 3'-deoxy-3'-[18F]-fluorothymidine (18FLT) positron emission tomography (PET) scanning was increased in pulmonary arterial hyperte...
Menon, Divya P Qi, Guanming Kim, Seung K Moss, M Elizabeth Penumatsa, Krishna C Warburton, Rod R Toksoz, Deniz Wilson, Jamie Hill, Nicholas S Jaffe, Iris Z
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Published in
Pulmonary circulation
Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells. Aldosterone levels are elevated in human pulmonary arterial hypertension and in experimental pulmonary hypertension, while inhibition of the aldosterone-binding mineralocorticoid...
