PirB regulates a structural substrate for cortical plasticity
Published in Proceedings of the National Academy of Sciences
PirB regulates a structural substrate for cortical plasticity
Published in Proceedings of the National Academy of Sciences
Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human an...
...Published in Proceedings of the National Academy of Sciences of the United States of America
Antibody cancer therapies rely on systemically accessible targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor site. Here, we present proof-of-principle of in vivo selection of human antibodies in tumor-bearing mice that identified a tumor-specific antibody able to deliver a payload and unveils the targ...
Genetic measurement of memory B-cell recall using antibody repertoire sequencing.
Published in Proceedings of the National Academy of Sciences of the United States of America
Annual influenza vaccinations aim to protect against seasonal infections, and vaccine strain compositions are updated every year. This protection is based on antibodies that are produced by either newly activated or memory B cells recalled from previous encounters with influenza vaccination or infection. The extent to which the B-cell repertoire re...
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.
...Published in Proceedings of the National Academy of Sciences
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in several pathological processes. VEGF-C signaling through VEGFR-3 promotes lymphangiogenesis, which is a clinically relevant target for treating lymphatic insufficiency and for blocking tumor angiog...
Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.
...Published in Proceedings of the National Academy of Sciences
The Drosophila defense against pathogens largely relies on the activation of two signaling pathways: immune deficiency (IMD) and Toll. The IMD pathway is triggered mainly by Gram-negative bacteria, whereas the Toll pathway responds predominantly to Gram-positive bacteria and fungi. The activation of these pathways leads to the rapid induction of nu...
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.
...Published in Proceedings of the National Academy of Sciences of the United States of America
Tumor heterogeneity of high-grade glioma (HGG) is recognized by four clinically relevant subtypes based on core gene signatures. However, molecular signaling in glioma stem cells (GSCs) in individual HGG subtypes is poorly characterized. Here we identified and characterized two mutually exclusive GSC subtypes with distinct dysregulated signaling pa...
Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
Published in Proceedings of the National Academy of Sciences of the United States of America
The circadian clock is constituted by a complex molecular network that integrates a number of regulatory cues needed to maintain organismal homeostasis. To this effect, posttranslational modifications of clock proteins modulate circadian rhythms and are thought to convert physiological signals into changes in protein regulatory function. To explore...
APR-246/PRIMA-1MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 m...
...Published in Proceedings of the National Academy of Sciences
p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) sy...
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.
...Published in Proceedings of the National Academy of Sciences of the United States of America
The molecular etiology of human progenitor reprogramming into self-renewing leukemia stem cells (LSC) has remained elusive. Although DNA sequencing has uncovered spliceosome gene mutations that promote alternative splicing and portend leukemic transformation, isoform diversity also may be generated by RNA editing mediated by adenosine deaminase act...
