Vollmers, Christopher Sit, Rene V Weinstein, Joshua A Dekker, Cornelia L Quake, Stephen R
Published in
Proceedings of the National Academy of Sciences of the United States of America
Annual influenza vaccinations aim to protect against seasonal infections, and vaccine strain compositions are updated every year. This protection is based on antibodies that are produced by either newly activated or memory B cells recalled from previous encounters with influenza vaccination or infection. The extent to which the B-cell repertoire re...
Leppänen, Veli-Matti Tvorogov, Denis Kisko, Kaisa Prota, Andrea E Michael Jeltsch Anisimov, Andrey Markovic-Mueller, Sandra Stuttfeld, Edward Goldie, Kenneth N Ballmer-Hofer, Kurt
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Published in
Proceedings of the National Academy of Sciences
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in several pathological processes. VEGF-C signaling through VEGFR-3 promotes lymphangiogenesis, which is a clinically relevant target for treating lymphatic insufficiency and for blocking tumor angiog...
Patel, Vishal Williams, Darren Hajarnis, Sachin Hunter, Ryan Marco Pontoglio Somlo, Stefan Igarashi, Peter
Published in
Proceedings of the National Academy of Sciences
Polycystic kidney disease (PKD), the most common genetic cause of chronic kidney failure, is characterized by the presence of numerous, progressively enlarging fluid-filled cysts in the renal parenchyma. The cysts arise from renal tubules and are lined by abnormally functioning and hyperproliferative epithelial cells. Despite recent progress, no Fo...
H, Fukuyama Y, Verdier Y, Guan C, Makino-Okamura V, Shilova X, Liu E, Maksoud J, Matsubayashi I, Haddad K, Spirohn
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Published in
Proceedings of the National Academy of Sciences
The Drosophila defense against pathogens largely relies on the activation of two signaling pathways: immune deficiency (IMD) and Toll. The IMD pathway is triggered mainly by Gram-negative bacteria, whereas the Toll pathway responds predominantly to Gram-positive bacteria and fungi. The activation of these pathways leads to the rapid induction of nu...
Mao, Ping Joshi, Kaushal Li, Jianfeng Kim, Sung-Hak Li, Peipei Santana-Santos, Lucas Luthra, Soumya Chandran, Uma R Benos, Panayiotis V Smith, Luke
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Tumor heterogeneity of high-grade glioma (HGG) is recognized by four clinically relevant subtypes based on core gene signatures. However, molecular signaling in glioma stem cells (GSCs) in individual HGG subtypes is poorly characterized. Here we identified and characterized two mutually exclusive GSC subtypes with distinct dysregulated signaling pa...
Masri, Selma Patel, Vishal R Eckel-Mahan, Kristin L Peleg, Shahaf Forne, Ignasi Ladurner, Andreas G Baldi, Pierre Imhof, Axel Sassone-Corsi, Paolo
Published in
Proceedings of the National Academy of Sciences of the United States of America
The circadian clock is constituted by a complex molecular network that integrates a number of regulatory cues needed to maintain organismal homeostasis. To this effect, posttranslational modifications of clock proteins modulate circadian rhythms and are thought to convert physiological signals into changes in protein regulatory function. To explore...
Jiang, Qingfei Crews, Leslie A Barrett, Christian L Chun, Hye-Jung Court, Angela C Isquith, Jane M Zipeto, Maria A Goff, Daniel J Minden, Mark Sadarangani, Anil
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Published in
Proceedings of the National Academy of Sciences of the United States of America
The molecular etiology of human progenitor reprogramming into self-renewing leukemia stem cells (LSC) has remained elusive. Although DNA sequencing has uncovered spliceosome gene mutations that promote alternative splicing and portend leukemic transformation, isoform diversity also may be generated by RNA editing mediated by adenosine deaminase act...
Smith, Alicia K. Fang, Hong Whistler, Toni Unger, Elizabeth R. Rajeevan, Mangalathu S.
Published in
Neuropsychobiology
Background: There is no consistent evidence of specific gene(s) or molecular pathways that contribute to the pathogenesis, therapeutic intervention or diagnosis of chronic fatigue syndrome (CFS). While multiple studies support a role for genetic variation in CFS, genome-wide efforts to identify associated loci remain unexplored. We employed a novel...
Rera, Michael Clark, Rebecca I Walker, David W
Published in
Proceedings of the National Academy of Sciences
Aging is characterized by a growing risk of disease and death, yet the underlying pathophysiology is poorly understood. Indeed, little is known about how the functional decline of individual organ systems relates to the integrative physiology of aging and probability of death of the organism. Here we show that intestinal barrier dysfunction is corr...
Othy, S. Topcu, S. Kaveri, S. Bayry, Jagadeesh
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