Masri, Selma Patel, Vishal R Eckel-Mahan, Kristin L Peleg, Shahaf Forne, Ignasi Ladurner, Andreas G Baldi, Pierre Imhof, Axel Sassone-Corsi, Paolo
Published in
Proceedings of the National Academy of Sciences of the United States of America
The circadian clock is constituted by a complex molecular network that integrates a number of regulatory cues needed to maintain organismal homeostasis. To this effect, posttranslational modifications of clock proteins modulate circadian rhythms and are thought to convert physiological signals into changes in protein regulatory function. To explore...
Jiang, Qingfei Crews, Leslie A Barrett, Christian L Chun, Hye-Jung Court, Angela C Isquith, Jane M Zipeto, Maria A Goff, Daniel J Minden, Mark Sadarangani, Anil
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Published in
Proceedings of the National Academy of Sciences of the United States of America
The molecular etiology of human progenitor reprogramming into self-renewing leukemia stem cells (LSC) has remained elusive. Although DNA sequencing has uncovered spliceosome gene mutations that promote alternative splicing and portend leukemic transformation, isoform diversity also may be generated by RNA editing mediated by adenosine deaminase act...
Published in
Proceedings of the National Academy of Sciences
RpfG is a paradigm for a class of widespread bacterial two-component regulators with a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. In the plant pathogen Xanthomonas campestris pv. campestris (Xcc), a two-component system comprising RpfG and the complex sen...
Michael Rera Clark, Rebecca I Walker, David W
Published in
Proceedings of the National Academy of Sciences
Aging is characterized by a growing risk of disease and death, yet the underlying pathophysiology is poorly understood. Indeed, little is known about how the functional decline of individual organ systems relates to the integrative physiology of aging and probability of death of the organism. Here we show that intestinal barrier dysfunction is corr...
Denissenko, Petr Kantsler, Vasily Smith, David J Kirkman-Brown, Jackson
Published in
Proceedings of the National Academy of Sciences
The migratory abilities of motile human spermatozoa in vivo are essential for natural fertility, but it remains a mystery what properties distinguish the tens of cells which find an egg from the millions of cells ejaculated. To reach the site of fertilization, sperm must traverse narrow and convoluted channels, filled with viscous fluids. To elucid...
Borucki, William J Boss, Alan P Ciardi, David R Quinn, Samuel N Steffen, Jason H Ragozzine, Darin Fabrycky, Daniel C Carter, Joshua A Ford, Eric B Holman, Matthew J
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Published in
Proceedings of the National Academy of Sciences
Eisen, Herman N Hou, Xun Helen Shen, Chase Wang, Kaidi Tanguturi, Varsha Keelara Smith, Crysela Kozyrytska, Katerina Nambiar, Lakshmi McKinley, Carol A Chen, Jianzhu
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Published in
Proceedings of the National Academy of Sciences
Algorithms derived from measurements of short-peptide (8-10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K(b), can bind well over 1 million different peptides with significant affinity (
Kristensen, Vessela N Vaske, Charles J Ursini-Siegel, Josie Van Loo, Peter Nordgard, Silje H Sachidanandam, Ravi Sørlie, Therese Wärnberg, Fredrik Haakensen, Vilde D Helland, Åslaug
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Published in
Proceedings of the National Academy of Sciences of the United States of America
We use an integrated approach to understand breast cancer heterogeneity by modeling mRNA, copy number alterations, microRNAs, and methylation in a pathway context utilizing the pathway recognition algorithm using data integration on genomic models (PARADIGM). We demonstrate that combining mRNA expression and DNA copy number classified the patients ...
Fusco S Ripoli C Podda MV Ranieri SC Leone L Toietta G McBurney MW Schutz G Riccio A Grassi C
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Published in
Proceedings of the National Academy of Sciences
Calorie restriction delays brain senescence and prevents neurodegeneration, but critical regulators of these beneficial responses other than the NAD(+)-dependent histone deacetylase Sirtuin-1 (Sirt-1) are unknown. We report that effects of calorie restriction on neuronal plasticity, memory and social behavior are abolished in mice lacking cAMP resp...
Keng, P. Y. Chen, S. Ding, H. Sadeghi, S. Shah, G. J. Dooraghi, A. Phelps, M. E. Satyamurthy, N. Chatziioannou, A. F. Kim, C.-J. C.
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Published in
Proceedings of the National Academy of Sciences
