Huemer, Markus Mairpady Shambat, Srikanth Bergada-Pijuan, Judith Söderholm, Sandra Boumasmoud, Mathilde Vulin, Clément Gómez-Mejia, Alejandro Antelo Varela, Minia Tripathi, Vishwachi Götschi, Sandra
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Staphylococcus aureus causes invasive infections and easily acquires antibiotic resistance. Even antibiotic-susceptible S. aureus can survive antibiotic therapy and persist, requiring prolonged treatment and surgical interventions. These so-called persisters display an arrested-growth phenotype, tolerate high antibiotic concentrations, and are asso...
Olguin-Olguin, Adan Aalto, Anne Maugis, Benoît Boquet-Pujadas, Aleix Hoffmann, Dennis Ermlich, Laura Betz, Timo Gov, Nir S Reichman-Fried, Michal Raz, Erez
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Published in
Proceedings of the National Academy of Sciences of the United States of America
To study the mechanisms controlling front-rear polarity in migrating cells, we used zebrafish primordial germ cells (PGCs) as an in vivo model. We find that polarity of bleb-driven migrating cells can be initiated at the cell front, as manifested by actin accumulation at the future leading edge and myosin-dependent retrograde actin flow toward the ...
Orkin, Joseph D Montague, Michael J Tejada-Martinez, Daniela de Manuel, Marc Del Campo, Javier Cheves Hernandez, Saul Di Fiore, Anthony Fontsere, Claudia Hodgson, Jason A Janiak, Mareike C
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Ecological flexibility, extended lifespans, and large brains have long intrigued evolutionary biologists, and comparative genomics offers an efficient and effective tool for generating new insights into the evolution of such traits. Studies of capuchin monkeys are particularly well situated to shed light on the selective pressures and genetic under...
Makarov, Dmitrii E
Published in
Proceedings of the National Academy of Sciences of the United States of America
Moncho-Amor, Veronica Chakravarty, Probir Galichet, Christophe Matheu, Ander Lovell-Badge, Robin Rizzoti, Karine
Published in
Proceedings of the National Academy of Sciences of the United States of America
P27, a cell cycle inhibitor, is also able to drive repression of Sox2 This interaction plays a crucial role during development of p27 -/- pituitary tumors because loss of one copy of Sox2 impairs tumorigenesis [H. Li et al., Cell Stem Cell 11, 845-852 (2012)]. However, SOX2 is expressed in both endocrine and stem cells (SCs), and its contribution t...
Gibaldi, Agostino Benson, Noah C Banks, Martin S
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Proceedings of the National Academy of Sciences of the United States of America
In mammals with frontal eyes, optic-nerve fibers from nasal retina project to the contralateral hemisphere of the brain, and fibers from temporal retina project ipsilaterally. The division between crossed and uncrossed projections occurs at or near the vertical meridian. If the division was precise, a problem would arise. Small objects near midline...
Costa, A. T. Gonçalves, P. A. D. Basov, D. N. Koppens, Frank H. L. Mortensen, N. Asger Peres, N. M. R.
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Proceedings of the National Academy of Sciences of the United States of America
We show that the Higgs mode of a superconductor, which is usually challenging to observe by far-field optics, can be made clearly visible using near-field optics by harnessing ultraconfined graphene plasmons. As near-field sources we investigate two examples: graphene plasmons and quantum emitters. In both cases the coupling to the Higgs mode is cl...
Zaccone, Alessio Trachenko, Kostya
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Proceedings of the National Academy of Sciences of the United States of America
Experimental observations of unexpected shear rigidity in confined liquids, on very low frequency scales on the order of 0.01 to 0.1 Hz, call into question our basic understanding of the elasticity of liquids and have posed a challenge to theoretical models of the liquid state ever since. Here we combine the nonaffine theory of lattice dynamics val...
Ni, Songwei Li, Baiyuan Tang, Kaihao Yao, Jianyun Wood, Thomas K. Wang, Pengxia Wang, Xiaoxue
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Proceedings of the National Academy of Sciences of the United States of America
Toxin–antitoxin (TA) loci were initially identified on conjugative plasmids, and one function of plasmid-encoded TA systems is to stabilize plasmids or increase plasmid competition via postsegregational killing. Here, we discovered that the type II TA system, Pseudoalteromonas rubra plasmid toxin–antitoxin PrpT/PrpA, on a low-copy-number conjugativ...
Poff, Kirsten E. Leu, Andy O. Eppley, John M. Karl, David M. DeLong, Edward F.
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Proceedings of the National Academy of Sciences of the United States of America
In the open ocean, elevated carbon flux (ECF) events increase the delivery of particulate carbon from surface waters to the seafloor by severalfold compared to other times of year. Since microbes play central roles in primary production and sinking particle formation, they contribute greatly to carbon export to the deep sea. Few studies, however, h...
