He, Ya-Jun Kuchta, Kenny Deng, Yan-Mei Cameron, Silke Lin, Yu Liu, Xu-You Ye, Guo-Ron Lv, Xia Kobayashi, Yuta Shu, Jian-Chang
...
Published in
Planta medica
Activation and proliferation of hepatic stellate cells (HSC) play an important role in the progress of liver fibrosis. HSC activation occurs in response to inflammatory cytokines, cellular interactions with immune cells, and morphogenetic signals. The literature hints to a role of the adaptor protein MyD88 in fibrosis. Although curcumin has been sh...
Zhang, Yanmin Chevalier, Arnaud Khdour, Omar M Soto, Larisa Morales Hecht, Sidney M
Published in
Planta medica
In a recent study, several new derivatives of antimycin A (AMA) were produced by means of a novel transacylation reaction, and these were shown to mediate selective toxicity toward cultured A549 human lung epithelial adenocarcinoma cells, as compared with WI-38 normal human lung fibroblasts. The purpose of our study was to investigate whether the a...
Ito, Chihiro Matsui, Takuya Niimi, Ai Tan, Hugh T-W Itoigawa, Masataka
Published in
Planta medica
The study of the chemical constituents of branches and twigs of Cratoxylum cochinchinense collected in Singapore led to the isolation and structural elucidation of four new xanthones, named cratoxanthone A (1), B (2), C (3), and D (4), together with six known xanthones (5-10) and one known dihydroanthracenone (11). Eight xanthones (including 1 and ...
Jiang, Xiao-Han Wu, Qing-Qing Xiao, Yang Yuan, Yuan Yang, Zheng Bian, Zhou-Yan Chang, Wei Tang, Qi-Zhu
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Planta medica
Evodiamine, a major component of Evodia rutaecarpa, can protect the myocardium against injury induced by atherosclerosis and ischemia-reperfusion. However, the effect of evodiamine against cardiac fibrosis remains unclear. This study aims to investigate the possible effect and mechanism involved in the function of evodiamine on isoproterenol-induce...
Issa, Mark E Cretton, Sylvian Cuendet, Muriel
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Planta medica
Multiple myeloma is characterized by the accumulation of malignant plasma cells in the bone marrow. Multiple myeloma is the second most frequently diagnosed hematological malignancy, predominantly affecting the elderly. Despite recent advances in the development of novel therapies, multiple myeloma remains an incurable malignancy where the majority...
Petit, Charlotte Ceccarelli, Martina Cretton, Sylvian Houriet, Joëlle Skalicka-Woźniak, Krystyna Christen, Philippe Carrupt, Pierre-Alain Goracci, Laura Wolfender, Jean-Luc
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Planta medica
Natural products are generally ingested as part of traditional herbal decoctions or in the current diet. However, in natural product research, the bioavailability of secondary metabolites is often poorly investigated. In this work, a systematic study was carried out in order to highlight the physicochemical parameters that mainly influence the pass...
El Bouakher, Abderrahman Jismy, Badr Allouchi, Hassan Duverger, Eric Barkaoui, Latifa El Hakmaoui, Ahmed Daniellou, Richard Guillaumet, Gérald Akssira, Mohamed
Published in
Planta medica
Motivated by the widely reported anticancer activity of parthenolides and their derivatives, a series of new substituted parthenolides was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 positions of 9α- and 9β-hydroxyparthenolide, which were isolated from the aerial parts of Anvillea radiata. Twenty-one derivat...
Santana, Marília T Cercato, Luana M Oliveira, Janaíne P Camargo, Enilton A
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Planta medica
Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the med...
Dong, Miao Liu, Dan Li, Yan-Hong Chen, Xuan-Qin Luo, Kai Zhang, Yong-Min Li, Rong-Tao
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Planta medica
Four new naphthoquinones (1-4), including a dimeric one, shikometabolin G (1), together with six known ones (6-10), were isolated from the methanol extract of Onosma paniculatum. Their structures were established based on the analysis of NMR and MS spectroscopic data. All of the compounds were evaluated for inhibitory effects on NO production in mu...
Czerwińska, Monika E Świerczewska, Anita Woźniak, Marta Kiss, Anna K
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Planta medica
In traditional medicine, flowers and aerial parts of Lamium album are assigned by their anti-inflammatory, antiseptic, and mucolytic activities, and are used in chronic bronchitis and pharyngitis as well as skin, vaginal, and cervical inflammation.The aim of the present study was to compare effects of ethanolic extracts prepared from flowers and ae...
