Liu, Wei Yan, Tingting Chen, Ken Yang, Li Benet, Leslie Z Zhai, Suodi
Published in
Pharmacotherapy
Lack of blood pressure control is often seen in hypertensive patients concomitantly taking antituberculosis medications due to the complex drug-drug interactions between rifampin and antihypertensive drugs. Therefore, it is of clinical importance to understand the underlying mechanisms of these interactions to help formulate recommendations on the ...
Pai, Manjunath P Debacker, Kenneth C Derstine, Brian Sullivan, June Su, Grace L Wang, Stewart C
Published in
Pharmacotherapy
High-dose methotrexate (HD-MTX) is used to treat primary central nervous system lymphoma (PCNSL), but potential differences in MTX clearance (CL) due to obesity have not been studied. We characterized the relationship between HD-MTX CL and computed tomography (CT)-generated body composition (morphomic), body size descriptors, and laboratory measure...
Shoair, Osama A Cook, Elizabeth A Shipman, Denver Dunn, Rebecca L
Published in
Pharmacotherapy
Generalized anxiety disorder (GAD) and major depressive disorder (MDD) are prevalent in patients with asthma. These disorders may increase asthma severity and decrease asthma control. No studies have evaluated the impact of achieving antidepressant target dose optimization compared with not achieving antidepressant target doses on asthma control in...
Lim, Sin Yin Sharan, Satish Woo, Sukyung
Published in
Pharmacotherapy
There is a large variation in cannabidiol (CBD) pharmacokinetics and little information on its bioavailability. This study aims to establish the CBD dose-exposure relationship and to evaluate the effects of dosage forms, food, and doses on CBD absorption. Single-dose (range: 5-6000 mg) CBD plasma concentration-time profiles administered as oral sol...
Smythe, Maureen A Parker, Dennis Garwood, Candice L Cuker, Adam Messé, Steve R
Published in
Pharmacotherapy
Patients with atrial fibrillation (AF) who suffer an acute ischemic stroke are at risk for both hemorrhagic transformation and recurrent ischemic stroke in the acute post-stroke period. Oral anticoagulants are recommended for secondary stroke prevention in patients with AF. The optimal time to initiate anticoagulant therapy after acute ischemic str...
Yerke, Jason R Sacha, Gretchen L Scheraga, Rachel G Culver, Daniel A Abraham, Susamma Torbic, Heather Lam, Simon W Ammar, Mahmoud A Olman, Mitchell A Bauer, Seth R
...
Published in
Pharmacotherapy
Positive hemodynamic response to vasopressin after 6 hours of infusion was independently associated with lower mortality in a previous retrospective study of patients with septic shock. However, factors previously associated with higher plasma vasopressin concentration were not associated with response, and the relationship between plasma vasopress...
Perreault, Sylvie de Denus, Simon White-Guay, Brian Côté, Robert Schnitzer, Mireille E Dubé, Marie-Pierre Dorais, Marc Tardif, Jean-Claude
Published in
Pharmacotherapy
Data on oral anticoagulant (OAC) uptake and pattern of use are limited. Real-life data in patients with atrial fibrillation (AF) are important for understanding patient exposure. A cohort study of new OAC users was built to assess trends of drug use from 2011 to 2017, persistence rate, switching rate, adherence level, and predictors of adherence. W...
Eshetie, Tesfahun C Nguyen, Tuan A Gillam, Marianne H Kalisch Ellett, Lisa M
Published in
Pharmacotherapy
People with Alzheimer's disease (AD) often have multimorbidity and take multiple medicines. Yet few studies have examined medicine utilization for comorbidities comparing people with and without AD. The aim was to investigate the patterns of medication use for comorbidities in people with and without AD. An Australian population-based study was con...
Cope, Rebecca J Fischetti, Briann S Kavanagh, Rebecca K Lepa, Trisha M Sorbera, Maria A
Published in
Pharmacotherapy
The prevalence of obesity among persons living with human immunodeficiency virus (HIV) has increased significantly and may be linked to the use of antiretroviral therapy. Although weight-loss medications approved by the U.S. Food and Drug Administration are recommended as an adjunct to diet and exercise to treat obesity in the general population, l...
Du, Xiaoli Peng, Wenxiu Fu, Qiang Ma, Qing Zhu, Zhu Li, Taisheng
Published in
Pharmacotherapy
To identify the pharmacokinetic differences of antiretroviral drugs between HIV-infected Chinese patients and patients of other race/ethnicities. Results from prospective, open-label pharmacokinetic studies among Chinese and historical data from other race/ethnicities. Pharmacokinetics of six commonly used antiretroviral drugs, including zidovudine...
