Lat, Ishaq Daley, Mitchell J Shewale, Anand Pangrazzi, Mark H Hammond, Drayton Olsen, Keith M
Published in
Pharmacotherapy
This study was conducted to describe the prevalence, epidemiology, and clinical outcomes of multidrug-resistant (MDR) organism (MDRO) pneumonia in critically ill patients. A multicenter, prospective, observational study of patients admitted to 60 intensive care units (ICUs), from 34 hospitals, in the United States from November to December 2016. Ad...
Reynolds, Paul M MacLaren, Robert
Published in
Pharmacotherapy
Because recent studies have challenged the efficacy of stress ulcer prophylaxis (SUP) in the critically ill patient, our objective was to evaluate the efficacy of SUP with proton pump inhibitors (PPIs) or histamine2 -receptor antagonists (H2 RAs) against placebo, control, no therapy, or enteral nutrition alone in critically ill adults. Meta-analysi...
Crass, Ryan L Pai, Manjunath P
Published in
Pharmacotherapy
Novel β-lactamase inhibitors have extended the reach of new and existing β-lactams against multidrug-resistant bacteria expressing β-lactamases. The efficacy of these combination therapeutics relies on a complex two-component pharmacodynamic (PD) system where the β-lactamase inhibitor inactivates the bacterial β-lactamase enzyme and frees the compa...
Smith, Steven M Lee, Jimin Lee, Sukhyang
Published in
Pharmacotherapy
Culbertson, Vaughn L Rahman, Shaikh Emdadur Bosen, Grayson C Caylor, Matthew L Xu, Dong
Published in
Pharmacotherapy
Numerous medications interact at serotonin (5-hydroxytryptamine [5-HT]) receptors directly or through off-target interactions, causing mild to severe serotonergic adverse drug events (ADEs), particularly among older adults. Our objective was to develop a novel molecular-based toxicity scoring system to assess serotonergic burden resulting from conc...
Flowers, Stephanie A Baxter, Nielson T Ward, Kristen M Kraal, A Zarina McInnis, Melvin G Schmidt, Thomas M Ellingrod, Vicki L
Published in
Pharmacotherapy
Previous studies identified shifts in gut microbiota associated with atypical antipsychotic (AAP) treatment that may link AAPs to metabolic burden. Dietary prebiotics such as resistant starch may be beneficial in obesity and glucose regulation, but little is known mechanistically about their ability to modify gut microbiota in AAP-treated individua...
Trujillo, Toby C Dobesh, Paul P Crossley, George H Finks, Shannon W
Published in
Pharmacotherapy
As overall prevalence of atrial fibrillation (AF) continues to rise, the number of patients who undergo ablation, or electrical/chemical cardioversion, to restore normal sinus rhythm continues to increase as well. As direct oral anticoagulants (DOACs) have continued to be incorporated into clinical practice for long-term anticoagulation for AF, exp...
Stainsby, Chris M Perger, Teodora M Vannappagari, Vani Mounzer, Karam C Hsu, Ricky K Henegar, Cassidy E Oyee, James Urbaityte, Rimgaile Lane, Charlotte E Carter, Lindsay M
...
Published in
Pharmacotherapy
Human leukocyte antigen (HLA)-B*5701 screening identifies patients at increased risk for abacavir (ABC) hypersensitivity reaction (HSR). Screening was adopted in GlaxoSmithKline and ViiV Healthcare clinical trials in 2007 and human immunodeficiency virus treatment guidelines in 2008. Company meta-analyses of trials pre-HLA-B*5701 screening reported...
Shaeer, Kristy M Zmarlicka, Monika T Chahine, Elias B Piccicacco, Nicholas Cho, Jonathan C
Published in
Pharmacotherapy
Plazomicin is a novel aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit, thus inhibiting protein synthesis in a concentration-dependent manner. Plazomicin displays a broad spectrum of activity against aerobic gram-negative bacteria including extended-spectrum β-lactamase-producing Enterobacteriaceae, carbapenem-resistant E...
Ou, Baochi Liu, Yuan Zhang, Tao Sun, Yahuang Chen, Jiayi Peng, Zhihai
Published in
Pharmacotherapy
There are limited markers that could facilitate individualized tacrolimus treatment in the early posttransplantation period. Genetic factors have been found to play critical roles in determining tacrolimus pharmacokinetics. We aimed to examine the association of donor and recipient Toll-like receptor (TLR) polymorphisms with tacrolimus elimination ...
