Chen, Gang Zhang, Dan Du, Aihua Zhang, Yanan Zhang, Ying Zhang, Lina Zang, Siqi Liu, Xiaona Wang, Zejuan Zhen, Haiqing
...
Published in
Pharmacotherapy
To evaluate the pharmacokinetic properties and safety of empagliflozin, and the bioequivalence of test formulation empagliflozin tablet compared with the brand-name drug Jardiance (reference formulation) after single oral administration under fasting and fed conditions in healthy Chinese subjects. An open-label randomized single-dose two-sequence, ...
CJ Jorgensen, Sarah LY Tse, Christopher Burry, Lisa Dresser, Linda D
Published in
Pharmacotherapy
A hyperinflammatory response to SARS‐CoV‐2 infection, reminiscent of cytokine release syndrome, has been implicated in the pathophysiology of acute respiratory distress syndrome and organ damage in patients with COVID‐19. Agents that inhibit components of the pro‐inflammatory cascade have garnered interest as potential treatment options with hopes ...
Johnson, Kristen M. Belfer, Julie J. Peterson, Gina R. Boelkins, Mark R. Dumkow, Lisa E.
Published in
Pharmacotherapy
Novel coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome virus (SARS‐CoV‐2) has become a global health care crisis. The Centers for Disease Control and Prevention (CDC) lists immunocompromised patients, including those requiring immunosuppression following renal transplantation, as high risk for severe disease from SARS...
Jorgensen, Sarah CJ Kebriaei, Razieh Dresser, Linda D
Published in
Pharmacotherapy
The global pandemic of novel coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has created an urgent need for effective antivirals. Remdesivir (formerly GS‐5734) is a nucleoside analogue pro‐drug currently being evaluated in COVID‐19 clinical trials. Its unique structural features allow high ...
Hillaker, Emily Belfer, Julie J. Bondici, Anamaria Murad, Hani Dumkow, Lisa E.
Published in
Pharmacotherapy
We present a case of late initiation of remdesivir antiviral therapy in the successful treatment of a patient with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in a mixed medical intensive care unit of a community teaching hospital. A previously healthy 40‐year‐old man was admitted to the hospital 3 days after the onset of coronavir...
Barlow, Ashley Landolf, Kaitlin M. Barlow, Brooke Yeung, Siu Yan Amy Heavner, Jason J. Claassen, Cassidy W. Heavner, Mojdeh S.
Published in
Pharmacotherapy
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has evolved into an emergent global pandemic. Coronavirus disease 2019 (COVID‐19) can manifest on a spectrum of illness from mild disease to severe respiratory failure requiring intensive care unit admission. As the incidence continues to rise at a rapid pace, critical car...
Lodise, Thomas P. Rybak, Michael J.
Published in
Pharmacotherapy
Sodhi, Mohit Etminan, Mahyar
Published in
Pharmacotherapy
Stringer, Kathleen A. Puskarich, Michael A. Kenes, Michael T. Dickson, Robert P.
Published in
Pharmacotherapy
Dashti‐Khavidaki, Simin Khalili, Hossein
Published in
Pharmacotherapy