Lockery, Jessica E Ernst, Michael E Broder, Jonathan C Orchard, Suzanne G Murray, Anne Nelson, Mark R Stocks, Nigel P Wolfe, Rory Reid, Christopher M Liew, Danny
...
Published in
Pharmacotherapy
Efforts to minimize medication risks among older adults include avoidance of potentially inappropriate medications. Contemporary analysis of medication use in community-dwelling older people compared with the general population is lacking. A total of 19,114 community-dwelling adults in Australia and the United States aged 70 years or older (65 year...
De Bie, Felix R Allegaert, Karel Hedrick, Holly L Rintoul, Natalie E Davidson, Alexander
Published in
Pharmacotherapy
TREPROSTINIL IS A PROSTACYCLIN ANALOG USED FOR TREATMENT OF PULMONARY HYPERTENSION (PH) IN ADULTS AND CHILDREN, CURRENTLY AWAITING CLINICAL ASSESSMENT FOR USE IN NEONATES.: OBJECTIVES: WE AIMED TO INVESTIGATE THE USE OF TREPROSTINIL IN NEONATES WITH PH ON EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) SUPPORT AND MEASURE PLASMA CONCENTRATIONS OF THE DR...
Dobesh, Paul P. Trujillo, Toby C.
Published in
Pharmacotherapy
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)has led to a world‐wide pandemic, and patients with the infection are referred to as having COVID‐19. Although COVID‐19 is commonly considered a respiratory disease, there is clearly a thrombotic potential that was not expected. The pathophysiology of the disease and subsequent coagulopath...
Rider, Taylor R Silinskie, Kevin M Hite, Mindee S Bress, Jonathan
Published in
Pharmacotherapy
Vancomycin pharmacokinetic data in critically ill patients receiving sustained low-efficiency dialysis (SLED) is limited. Published data using vancomycin with intermittent hemodialysis and continuous renal replacement therapy may not be applicable to hybrid dialysis modalities such as SLED. Current drug references lack recommendations for vancomyci...
Young, Eric H Panchal, Rupesh M Yap, Alexander G Reveles, Kelly R
Published in
Pharmacotherapy
Prior studies have found that outpatient antibiotics are commonly prescribed for non-bacterial conditions. It is unclear if national prescribing has changed in recent years given recent public health and antimicrobial stewardship initiatives. This study aimed to describe antibiotic prescribing in United States (U.S.) physician offices. This was a c...
Simmering, Jacob E. Polgreen, Linnea A. Polgreen, Philip M. Teske, Rebecca E. Comellas, Alejandro P. Carter, Barry L.
Published in
Pharmacotherapy
Hydroxychloroquine combined with azithromycin has been investigated for activity against coronavirus disease 2019 (COVID‐19), but concerns about adverse cardiovascular (CV) effects have been raised. This study evaluated claims data to determine if risks for CV events were increased with hydroxychloroquine alone or combined with azithromycin. We ide...
Saunders, Ila M Tan, Marisela Koura, Divya Young, Rebecca
Published in
Pharmacotherapy
Annually, ~50,000 patients undergo hematopoietic stem cell transplantation (HCT) worldwide with almost 22,000 of these patients receiving HCT in the United States. HCT is a curative option for a wide range of hematologic malignancies, and advances in transplantation medicine have resulted in an increase in HCT survivors. It is anticipated that the ...
DiMaggio, Elizabeth
Published in
Pharmacotherapy
Acute graft-versus-host disease remains a devastating complication following hematopoietic cell transplantation, resulting in increased morbidity and mortality. Vast research efforts continue to refine or develop new means of prediction, assessment, prevention, and treatment of this syndrome. Recent updates in acute graft-versus-host disease includ...
Chau, Cindy H. Strope, Jonathan D. Figg, William D.
Published in
Pharmacotherapy
Given the global nature of the COVID‐19 pandemic, the need for disease detection and expanding testing capacity remains a critical priority. This review discusses the technological advances in testing capability and methodology that are currently employed or in development for detecting the novel coronavirus. We describe the current clinical diagno...
Dhanani, Jayesh A Lipman, Jeffrey Pincus, Jason Townsend, Shane Livermore, Amelia Wallis, Steven C Pandey, Saurabh Abdul-Aziz, Mohd H Roberts, Jason A
Published in
Pharmacotherapy
Extracorporeal membrane oxygenation (ECMO) therapy could affect drug concentrations via adsorption onto the oxygenator and/or associated circuit. We describe a case of a 33-year-old man with severe respiratory failure due to Pneumocystis jirovecii infection on a background of recently diagnosed human immunodeficiency virus infection. He required ve...
