Lebreton, Vincent Bourcier, Blandine Cosson, Karine Lagarce, Frédéric Spiesser-Robelet, Laurence Vrignaud, Sandy
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Pharmaceutical Technology in Hospital Pharmacy
Objectives Hydroxychloroquine (HCQ) presents many drug properties that increase its therapeutic use. There are, indeed, different research pathways in numerous autoimmune, inflammatory, and infectious diseases, as well as in cancerology. HCQ is only marketed as HCQ sulfate in film-coated or coated tablets for oral use. No pediatric liquid form is c...
Dozias, Gautier Thiec, Julie Le Den, Gwenola Cogulet, Virginie
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Pharmaceutical Technology in Hospital Pharmacy
Objectives An audit of the practices of our compounding unit was performed in 2016: areas of improvement were proposed, such as the automatization of our process. An automated compounder was acquired (MediMixmulti® MF4120R). The aim of the study was to anticipate the risks of the new process, in order to improve its security and to support the prof...
Hecq, Jean-Daniel Jamart, Jacques Odou, Pascal Vigneron, Jean Galanti, Laurence
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Pharmaceutical Technology in Hospital Pharmacy
The physico-chemical stability of an injectable preparation (IV) is conditioned by different parameters. A collaboration between the pharmacy, the chemistry laboratory and the statisticians of the scientific support unit was established in 1996, in order to carry out long-term chemical stability studies of commonly used IVs and to be able to take c...
Schmitt, Camille Fouque, Julien Blondeel-Gomes, Sandy Provost, Claire Da Costa Branquinho, Emilie Madar, Olivier
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Pharmaceutical Technology in Hospital Pharmacy
Introduction To reduce costs of gallium-68 activity in nuclear medicine, a subcontracting activity has been settled for [68Ga]Ga-edotreotide preparations. Cold kits are radiolabeled in our radiopharmacy and shipped out to nearby hospitals. According to the Summary of Product Characteristics (SmPC), preparations must be stored below 25 °C until expi...
Matheron, Agnès Guerault, Marie-Noelle Vazquez, Raphael Cheron, Mireille Brossard, Denis Crauste-Manciet, Sylvie
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Pharmaceutical Technology in Hospital Pharmacy
Objectives The objectives were to assess the microbiological stability and the physical enclosure integrity of the overwrapping for batch production of standard cytotoxic injectable solutions. Methods Broth culture media were used in place of cytotoxic drugs to assess the worst case in term of microbiological contamination risk. Iterative sterility...
Merienne, Camille Marchand, Chloe Filali, Samira Salmon, Damien Pivot, Christine Pirot, Fabrice
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Pharmaceutical Technology in Hospital Pharmacy
Background Stability of low amoxicillin oral dosage form (5 mg) used in reintroduction drug test was not fully documented. Furthermore, the impact of (1) salt moiety of amoxicillin and (2) amoxicillin – excipient interactions upon the antibiotic formulation stability during the storage was not characterized so that the estimation of the pharmaceuti...
Di-Falco, Elodie Bourbon, Johan Sbaffe, Isalyne Kaiser, Jean-Daniel
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Pharmaceutical Technology in Hospital Pharmacy
Alsace, in particular Haut-Rhin, is one of the main clusters of COVID-19 in France. There has been a shortage of essential supplies in the area, especially alcohol-based hand sanitizer. In this context, and in accordance with the decree dated March 6, 2020, our hospital management team asked us to start local production of alcohol-based handrub. Th...
Villain, Alexandre Sakji, Ilyes Bogart, Emilie Strobbe, Geoffrey Marliot, Guillaume Feutry, Frédéric
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Pharmaceutical Technology in Hospital Pharmacy
Objectives Preparation of 5-FU elastomeric pumps is a time-consuming activity inducing musculoskeletal disorders (MSDs). Our unit has developed an automated filling system consisting of two peristaltic pumps (one for the diluent, one for the cytotoxic drug). The objective was to validate the accuracy of the assembly and evaluate the impact of autom...
Polo, Caroline D’Huart, Elise Lesperlette, Gwendoline Vigneron, Jean Meyer, Florence Demoré, Béatrice
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Pharmaceutical Technology in Hospital Pharmacy
Objectives Concomitant administration of two incompatible drugs in the same infusion line can lead to a precipitation which could have clinical consequences for patients. The objective of this work was to study the physical compatibility of injectable posaconazole with other drugs commonly used in an adult hematology care unit. Methods The most wid...
Hejaz, Hatem A. Kanan, Ayat Al Mohtaseb, Mahmood Ja’bari, Ameer
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Pharmaceutical Technology in Hospital Pharmacy
Objectives The oral route is the most common route of administration of drugs because of the low cost of therapy, ease of administration, patient compliance, and flexibility in formulation. Taking oral medicine is extremely odious to some patients, such as pediatric and geriatric patients. Paracetamol is one of the most used antipyretic and analges...
