Sessink, Paul Cajaraville, Gerardo Tamés, Maria José Riestra, Ana Alcorta, Andrea Telleria, Naiara Grisaleña, Jaione
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives To measure cross-contamination between batches of different sensitizing drugs, contamination on the outside of compounded syringes, and drug concentrations in environmental air when using an automated compounding device. Methods One batch of piperacillin/tazobactam syringes followed by one batch of meropenem syringes were compounded dail...
Li, Sean Gabriel, Justin Martinez, Marilyn Longstaff, David Coffey, Martin Zhao, Fang
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Milk related materials are frequently used as a vehicle for drug product administration. Therefore, drug solubility information in milk related vehicles is desirable for prediction of how they may influence in vivo drug release and bioavailability. However, there are very limited data published on this topic. This study explored a practi...
Plaidy, Pauline Bouattour, Yassine Yessaad, Mouloud Sautou, Valérie Chennell, Philip
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Ceftazidime (CZ) and Vancomycin (VM) are used to treat bacterial keratitis; however, their physicochemical incompatibility does not allow their co-administration. This incompatibility can be managed by buffering the mixture at an alkaline pH or by using cage molecules such as cyclodextrins (CD). The objective of this work was to compare ...
van der Nat, Denise J. Lindemans, Anouk D. van Rijn, Laurens C. Ruijgrok, Elisabeth J.
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Vaccines are used on a large scale for prevention of disease. Preparing vaccines for administration can be a time consuming process. To increase efficacy of vaccine administration, the Vaxtractor was designed in January 2021. With the Vaxtractor, the desired volume of vaccine is drawn up automatically in syringes from two vials of vaccin...
D’Huart, Elise Sacrez, Matthieu Vigneron, Jean Sobalak, Nathalie Demoré, Béatrice
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives To the best of our knowledge, few studies have been published on the stability of cabazitaxel in infusion bags. Stabilis® database has selected a study demonstrating the stability of this molecule at 0.15 mg/mL for 28 days at 4 °C and 25 °C in polyolefin bags. The aim of this work was to study the physicochemical stability of Cabazitaxel...
Almasi, Jannik Thiesen, Judith Krämer, Irene
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Durvalumab (Imfinzi®), a PD-L1 monoclonal antibody (mAb) medication is available as concentrate (50 mg/mL) for solution for infusion. The summary of product characteristics provides information about the physicochemical stability of ready-to-administer durvalumab preparations (vehicle solution 0.9 % NaCl, G5%), but not about the concentr...
Almasi, Jannik Erdnüß, Frank Thiesen, Judith Krämer, Irene
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives To date, there is only one study investigating the physicochemical stability of diluted mitomycin (MMC) solutions prepared by using urea-containing Mitomycin medac as starting material. The aim of the study was to test the solubility of the new MMC formulation with regard to highly concentrated solutions and determine the physicochemical...
Cohen, Alejandro M. Wiseman, Luke Al Faraj, Ahmed Andreou, Pantelis Hall, Richard Neira, Victor M.
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives There are concerns about the potency of epinephrine (EPI), norepinephrine (NE), and phenylephrine (PE) stored in syringes for later infusions in clinical care. The objective of our study was to optimize a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to determine the concentrations EPI, NE, and PE dissolved in normal s...
Vigneron, Jean Sacrez, Matthieu D’Huart, Élise Demoré, Béatrice
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives The measurement of osmolality is used by many authors as an additional stability criterion of a drug in solution. In the current state of knowledge, no scientific publication correlates the osmolality values and the stability of a solution. To study the relevance of this analytical technique by measuring the osmolality of injectable solu...
Khan, Aasfa Venet, Arnaud Bernadou, Jean-Marc Cresto, Sylvie Servant, Vincent Boulestreau, Hélène Xuereb, Fabien Crauste-Manciet, Sylvie
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Fungal keratitis is a rare but severe cause of infectious keratitis and can lead to blindness. To cure fungal keratitis, antifungal like voriconazole eye drops must be immediately administered. As no brand is available on the market, voriconazole ophthalmic solution is compounded in hospital pharmacies using voriconazole powder for intra...
