Kozhevnikova, L M Mesitov, M V Moskovtsev, A A
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
We investigated the role of 5HT2C receptors in regulation of blood vessel contractility. We determined expression of 5HT2C receptors in smooth muscle cell line A7r5 as well as on isolated rat aorta. It was shown that strong vasoconstriction effect of 5HT2C receptor agonists - SCH 23390 and MK 212 appeared on blood vessels after preliminary activati...
Kirova, Yu I Shakova, F M Germanova, E L Paltsyn, A A Romanova, G A Rybnikova, Ye A Lukyanova, L D
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
Using immunohistochemical method, it was demonstrated that neurons of the cerebral cortex have the capacity to express hypoxia-inducible factor-1 alpha (HIF-1α) in normoxia. Intensity of this process is different for rats having unequal tolerance to hypoxia. Basal HIF-1α expression in neurons of rats with low-resistance (LR) to hypoxia is higher co...
Alchinova, I B Arkhipova, E N Medvedeva, Yu S Ezhova, O A Cherepov, A B Karganov, M Yu
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
We reproduced mouse model of bronchial asthma, evaluated metabolic shifts of serum homeostasis during disease development, and compared these results with the data on metabolic shifts in bronchial asthma patients. In experimental mice pronounced pathological changes in the lungs, considerable lymphocytosis and decrease in neutrophil count were dete...
Mamalyga, M L
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
Imbalance of the autonomic regulation of the heart occurs in asymptomatic the stage of Parkinson's disease. In the beginning of the symptomatic stage increases dysfunction of the heart. Vegetative balance is shifting in the direction of increasing the sympathetic effects on the heart and reduce the parasympathetic. Heart disorders associated with P...
Bespalov, A G Tregub, P P Kulikov, V P Pijanzin, A I Belousov, A A
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
Studied the role of VEGF, HSP-70 and S-100B in potentiating hypercapnia neuroprotective effect of hypoxia. Demonstrated that neuroprotective effects when exposed hypercapnic hypoxia-mediated protein synthesis increased S-100B, mainly due to the action of carbon dioxide, and not oxygen deficiency. Neuroprotective effects of HSP-70 due to hypoxia, bu...
Gusev, E Yu Chereshnev, V A
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
Systemic inflammation (SI) as a general pathological process is considered as a development of cellular stress in response to systemic action of damage factors. An Acute SI is characterized by wavelike course (a changing of activation and inhibition phases); a chronic SI is characterized by successive changing of stages of its progressive developme...
Kuznetsova, E I
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
The main results obtained in the present study were that 1) Prior to initiation of treatment of children with LT had a EEG changes, indicating certain dysfunction of diencephalic structures of the brain, and probably due to metabolic disorders that affect the neurotransmitter metabolism. 2) Toxic effects of chemotherapy on the CNS program was shown...
Komissarova, S V Dubrovin, I P Paltsyn, A A
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
Describes the development of ideas about the regeneration of neurons from the approval "neurons are not restored" to an avalanche stream of messages on neurogenesis. We analysing literature about four ways of neuron regeneration. 1--neurogenesis; 2--intracellular regeneration; 3--BMDC fusion with Purkinje neurons in transgenic experiment; 4--region...
Chausova, S V Gurevich, K G Bondareva, G P Filatov, O Ju Malyshev, I Y
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
We investigated the intensity of barium sulfate stimulated luminol-dependent chemiluminescence (SLCL) of pre-incubated blood with various concentrations of sodium salicylate, sodium metamizol or sodium diclofenac. Blood was received from healthy donors and patients with intolerance to aspirin and/or sodium metamizol and/or sodium diclofenac. Reveal...
Khugaeva, V K
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
In the dynamics of the experimental renal and hormonal hypertension in rats tracked change parameters such as blood pressure (BP), angiogenesis in microvessels of mesentery in small intestine, the number of mast cells (MC) surrounding microvessels. The same increase in BP there were qualitative and quantitative differences of angiogenesis in microv...
